Patents by Inventor Michael W. Laird

Michael W. Laird has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modified Shine-Dalgarno Sequences and Methods of Use Thereof
    Publication number: 20080274503
    Abstract: Novel Shine-Dalgarno (ribosome binding site) sequences, vectors containing such sequences, and host cells transformed with these vectors are provided. Methods of use of such sequences, vectors, and host cells for the efficient production of proteins and fragments thereof in prokaryotic systems are also provided. In particular embodiments of the invention, compounds and methods for high efficiency production of soluble protein in prokaryotic systems are provided.
    Type: Application
    Filed: June 19, 2008
    Publication date: November 6, 2008
    Applicant: Human Genome Sciences, Inc.
    Inventor: Michael W. Laird
  • Albumin Fusion Proteins
    Publication number: 20080194481
    Abstract: The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.
    Type: Application
    Filed: October 31, 2007
    Publication date: August 14, 2008
    Inventors: Craig A. Rosen, Adam Bell, Paul A. Moore, Yanggu Shi, David LaFleur, Jason B. Bock, Michael W. Laird, William A. Haseltine, Douglas B. Woods, Mani Subramanian
  • Modified Shine-Dalgarno sequences and methods of uses thereof
    Patent number: 7405059
    Abstract: Novel Shine-Dalgarno (ribosome binding site) sequences, vectors containing such sequences, and host cells transformed with these vectors are provided. Methods of use of such sequences, vectors, and host cells for the efficient production of proteins and fragments thereof in prokaryotic systems are also provided. In particular embodiments of the invention, compounds and methods for high efficiency production of soluble protein in prokaryotic systems are provided.
    Type: Grant
    Filed: June 7, 2006
    Date of Patent: July 29, 2008
    Assignee: Human Genome Sciences, Inc.
    Inventor: Michael W. Laird
  • Modified shine-dalgarno sequences and methods of use thereof
    Patent number: 7094573
    Abstract: Novel Shine-Dalgarno (ribosome binding site) sequences, vectors containing such sequences, and host cells transformed with these vectors are provided. Methods of use of such sequences, vectors, and host cells for the efficient production of proteins and fragments thereof in prokaryotic systems are also provided. In particular embodiments of the invention, compounds and methods for high efficiency production of soluble protein in prokaryotic systems are provided.
    Type: Grant
    Filed: December 7, 2004
    Date of Patent: August 22, 2006
    Assignee: Human Genome Sciences, Inc.
    Inventor: Michael W. Laird
  • Method of making FGF-12 and KGF-2
    Publication number: 20030119108
    Abstract: The present invention is directed to a method of expressing KGF-2 polypeptides in an ompT-deficient prokaryotic host cell. Also provided are ompT-deficient prokaryotic host cells comprising polynucleotides encoding KGF-2. The present invention is further directed to a method of expressing FGF-12 in an ompT-deficient prokaryotic host cell. Also provided are ompT-deficient prokaryotic hot cells comprising polynucleotides encoding FGF-12.
    Type: Application
    Filed: July 12, 2002
    Publication date: June 26, 2003
    Applicant: Human Genome Sciences, Inc.
    Inventor: Michael W. Laird