Abstract: Methods and compositions for treating leukemia are disclosed. Acylated 6-aminoindoles, acylated 6-aminopyrrolopyridines and acylated 3-aminopyrrolo[3,2-c]pyridazines of the following formula inhibit ENL/AF9 YEATS and are therefore useful for treating leukemia.

Abstract: An ultrasonic surgical instrument includes a body, an ultrasonic supported by the body, a shaft extending distally from the body and defining a shaft axis, a waveguide extending distally through the shaft, and an end effector arranged at a distal end of the shaft. The end effector includes an ultrasonic blade coupled to a distal end of the waveguide and having a primary blade treatment surface configured to treat tissue, and a clamp arm coupled to the distal end of the shaft. The shaft and the waveguide are selectively rotatable relative to one another about the shaft axis through a predefined range of angular motion between an assembly state and an operational state. In the assembly state, the clamp arm and the primary blade treatment surface are rotationally offset from one another. In the operational state, the clamp arm and the primary blade treatment surface are rotationally aligned.

Abstract: Embodiments herein relate to oil condition sensing systems and related methods. In a first aspect, an oil condition sensing system is included having a control circuit, a temperature sensor, and a fluid property sensor, wherein the fluid property sensor measures fluid properties including at least dielectric constant and the oil condition sensing system is configured to automatically detect when an oil change event has occurred, record the fluid property sensor data as new baseline fluid property data after an oil change event has occurred, and evaluate the condition of an engine oil based on a comparison with the baseline fluid property data. The oil condition sensing system can be configured to automatically detect the oil change event by evaluating signals from the fluid property sensor and interpret a change in dielectric constant and/or viscosity crossing a threshold value as an oil change event. Other embodiments are also included herein.

Abstract: A gas turbine engine fuel supply system can include a fuel delivery system, a thermal management system, a fuel manifold, and one or more sensors that identify one or more fuel parameters. A fuel control system adjusts parameters of the fuel based on data received from the sensors.

Abstract: A gas turbine engine fuel supply system can include a fuel delivery system, a thermal management system, a fuel manifold, and one or more sensors that identify one or more fuel parameters. A fuel control system adjusts parameters of the fuel based on data received from the sensors.

Abstract: A back pad assembly for a material handling vehicle is provided that includes a back pad, a framework, and a mounting frame. The back pad includes a center portion, a first side portion, and a second side portion. The first side portion defines a first curved profile, and the second side portion defines a second curved profile. The first curved profile and the second curved profile are arranged on laterally-opposing sides of the center portion. The framework includes a first mounting bar and a second mounting bar. The framework is coupled to the back pad. The first and second mounting bars are adjustably supported by the mounting frame to enable the back pad to be selectively mounted at varying heights along the mounting frame.

Abstract: Markers (e.g., treatment site markers, biopsy site markers) are composed of a non-metallic material having a composition and/or other features or characteristics such that the markers will generate twinkling artifacts when imaged with ultrasound. In this way, the composition of the markers enables their detection and localization using ultrasound. The markers are generally composed of non-metallic materials that enhance the twinkling artifact.

Abstract: An apparatus comprises a body assembly, a shaft, an acoustic waveguide, an articulation section, an end effector, and an articulation drive assembly. The shaft extends distally from the body assembly and defines a longitudinal axis. The acoustic waveguide comprises a flexible portion. The articulation section is coupled with the shaft. A portion of the articulation section encompasses the flexible portion of the waveguide. The articulation section comprises a plurality of body portions aligned along the longitudinal axis and a flexible locking member. The flexible locking member is operable to secure the body portions in relation to each other and in relation to the shaft. The end effector comprises an ultrasonic blade in acoustic communication with the waveguide. The articulation drive assembly is operable to drive articulation of the articulation section to thereby deflect the end effector from the longitudinal axis.

Abstract: An external fixation system for the correction of long bone deformities includes an elongate beam element having an engagement feature along a longitudinal edge of the elongate beam element, a connector element secured to the elongate beam and structurally configured to support a first bone anchor extending from the external fixation system, and a movable carriage engaged with the engagement feature along the longitudinal edge of the elongate beam element and selectively movable along the engagement feature of the elongate beam element. The movable carriage is selectively lockable into a position along the elongate beam element. The movable carriage is structurally configured to support a second bone anchor extending from the external fixation system.

Abstract: A sterilization enclosure to be placed within a sterilizer, the sterilization enclosure defining an interior for accommodating at least one surgical instrument and maintaining sterility of the at least one surgical instrument after the sterilization enclosure is removed from the sterilizer. The enclosure comprising a light source and a transparent window. The light source to illuminate the interior and the transparent window positioned such that the interior and the at least one surgical instrument are visible through the transparent window. A process indicator that is either disposed within the interior or coupled to an external surface of the sterilization enclosure. The process indicator in fluid communication with the interior of the sterilization enclosure such that the process indicator is exposed to a sterilant agent disposed within the interior of the sterilization enclosure to measure a characteristic within the interior during a sterilization process.

Abstract: A matrix for neuron regeneration. The matrix can include a sheet having a first surface and a second surface opposite the first surface, the second surface having a plurality of integrally formed ridges. The sheet can have a spiral shape, such that the first surface of the sheet faces the second surface of the sheet. The sheet and the integrally formed ridges can comprise oligo(poly(ethylene glycol) fumarate).

Abstract: For making battery electrodes, a composite strip of a cast ribbon of an electrically conductive metal attached to and extending along an edge of a web of electrically conductive carbon fiber material, also called a carbon felt in some examples, with a plurality of spaced apart notches cast in the ribbon and opening to an edge of the ribbon spaced from the carbon fiber material. A rotatable drum with a mold cavity and a confronting casting shoe for supplying molten metal, such as liquid lead, to the cavity may be used in a casting machine to continuous cast the composite strip.

Abstract: A container component decorating system has a decorating station (156), a container component handling module (102), a supply of colored inks, and inkjet printheads (124). The decorating station (156) delivers art graphics to container components (14) in a manufacturing queue (22). The inkjet printheads (124) comprise nozzles through which the colored inks are delivered. A flush cycle controller activated a flush cycle of the nozzles to deposit a flush cycle ink pattern (109) on a substrate to restore a meniscus (110) on the nozzles.

Abstract: A system for decorating multiple containers in a single manufacturing run has a decorator, which includes a source of ink and print site where an ink graphic is deposited to each container in a plurality of containers that make up a manufacturing queue. An inspection station is located downstream from the decorator. The inspection station performs an optical evaluation of a quality of a pattern of ink deposited on at least one container in the plurality of containers A closed-loop feedback is responsive to the inspection station wherein the decorator is automatically adjusted in response to the optical evaluation performed at the inspection station.

Abstract: A computer-implemented method includes receiving information expressing a user's interest in one or more media programs, obtaining information indicative of popularity for a plurality of media programs responsive to the received information by individuals other than the user, and transmitting one or more recommendations of media programs for display to the user, from the plurality of media programs that relate to the received information.

Abstract: A computer-implemented method includes receiving information expressing a user's interest in one or more media programs, obtaining information indicative of popularity for a plurality of media programs responsive to the received information by individuals other than the user, and transmitting one or more recommendations of media programs for display to the user, from the plurality of media programs that relate to the received information.

Abstract: The present disclosure sets forth various embodiments of power reception kits and methods. In one embodiment, a guided surface wave receive structure is configured to obtain electrical energy from a guided surface wave travelling along a terrestrial medium. Power output circuitry having a power output is configured to be coupled to an electrical load. The electrical load is experienced as a load at an excitation source coupled to a guided surface waveguide probe generating the guided surface wave. At least one connector is configured to couple the at least one guided surface wave receive structure to the power output circuitry.

Abstract: Disclosed are various embodiments of load shedding techniques for a guided surface wave power delivery system. In one embodiment, among others, a guided surface waveguide probe is configured to transmit a guided surface wave along a lossy conducting medium; and a load shedding controller device is configured to send load shedding instructions to a plurality of user devices. The load shedding instructions regulate user device consumption of electrical energy provided by the guided surface wave amongst the plurality of user devices by spreading out activation and deactivation of load shedding conservations amongst the plurality of user devices.

Abstract: Disclosed are various approaches for measuring and reporting the amount of electrical power consumed by an electrical load attached to a guided surface wave receive structure. A guided surface wave receive structure is configured to obtain electrical energy from a guided surface wave traveling along a terrestrial medium. An electrical load is coupled to the guided surface wave receive structure, the electrical load being experienced as a load at an excitation source coupled to a guided surface waveguide probe generating the guided surface wave. An electric power meter coupled to the electrical load and configured to measure the electrical load.

Abstract: The present disclosure is directed to mobile guided surface waveguide probes and receivers. In a representative embodiment, an excitation source such as a generator is coupled to a guided surface waveguide probe. The excitation source and the guided surface waveguide probe are mounted to a rigid frame for transport.