Abstract: Sensors and methods for determining the state of charge of a battery are described. The state of charge is determined in some instances by applying a current perturbation having a frequency to the battery terminals, monitoring the response signal, and determining the phase of the response signal. The phase may be correlated to the state of charge of the battery, so that once the phase is determined, a determination of the state of charge of the battery may be made. In some situations, the state of charge may be used to determine the operating condition of a load connected to the battery. In some embodiments, the state of charge may be used to determine whether the battery is defective.

Abstract: Various techniques for determining self-discharge rates of one or more battery cells, such as by determining a current leakage of the battery cell(s), are described. The techniques may improve the effective ADC linearity. An example of a technique may calculate the average time when each ADC digital code is observed, such as for a given battery cell or battery module, which allows the battery cell discharge rate to be estimated from the interval between the average time observed for neighboring, e.g., adjacent, digital codes. This approach allows the self-discharge rate of a battery cell to be calculated with high resolution even when the total cell voltage excursion is only a few least significant bits (LSBs).

Abstract: A cannula assembly includes a cannula, polymeric support material and a hub. The cannula has a proximal end and a distal end. The polymeric support material substantially surrounds a portion of the cannula at or near the proximal end. The hub is configured to be attached to a syringe. The polymeric support material is located between the cannula and the hub. The cannula, the polymeric support material and the hub are adhesively attached.

Abstract: Sensors and methods for determining the state of charge of a battery are described. The state of charge is determined in some instances by applying a current perturbation having a frequency to the battery terminals, monitoring the response signal, and determining the phase of the response signal. The phase may be correlated to the state of charge of the battery, so that once the phase is determined, a determination of the state of charge of the battery may be made. In some situations, the state of charge may be used to determine the operating condition of a load connected to the battery. In some embodiments, the state of charge may be used to determine whether the battery is defective.

Abstract: The present invention relates to methods of administration of rAAV vectors in a single administration method comprising a series of sub-administrations of sub-doses of rAAV vectors. The present invention also relates to rAAV vectors comprising cardiac-specific promoters, cardiac-cell specific promoters, multi-cell cardiac specific promoters, and elements thereof. The invention also relates to rAAV vectors, pharmaceutical compositions and uses thereof in methods for treating cardiovascular disease, heart diseases and heart failure in subjects in need thereof.

Abstract: Sensors and methods for determining the state of charge of a battery are described. The state of charge is determined in some instances by applying a current perturbation having a frequency to the battery terminals, monitoring the response signal, and determining the phase of the response signal. The phase may be correlated to the state of charge of the battery, so that once the phase is determined, a determination of the state of charge of the battery may be made. In some situations, the state of charge may be used to determine the operating condition of a load connected to the battery. In some embodiments, the state of charge may be used to determine whether the battery is defective.

Abstract: Recombinant AAV (rAAV) vectors comprising a rAVV genome comprising a heterologous nucleic acid encoding a lysosomal protein, e.g., acid alpha-glucosidase (GAA) polypeptide, and optionally a signal peptide and/or optionally a targeting sequence, e.g., IGF2 targeting peptide, operatively linked to a liver-specific promoter (LSP), enabling the GAA polypeptide to be secreted from the liver and targeted to the lysosomes. Particular embodiments relate to a recombinant AAV (rAAV) vector encoding an alpha-glucosidase (GAA) polypeptide, having a liver secretory signal peptide and a IGF2 targeting peptide that binds human cation-independent mannose-6-phosphate receptor (CI-MPR) or to the IGF2 receptor, permitting proper subcellular localization of the GAA polypeptide to lysosomes. Also encompassed are cells, and methods to treat a lysosomal disease, for example, a glycogen storage disease type II (GSD II) disease and/or Pompe Disease with the rAAV vector.

Abstract: Described herein are methods and compositions related to vectors, including but not limited to a method for treating cystic fibrosis (CF) using adeno-associated vims (AAV) particles, using a catheter to administer a population of viral vectors to a plurality of target sites in a subject by bronchial artery catheterization delivery.

Abstract: Vectors including viral vectors comprising a genome comprising a heterologous nucleic acid encoding a lysosomal targeting sequence, fused to a lysosomal storage enzyme, enabling the lysosomal enzyme to be targeted to the lysosomes. Particular embodiments relate to a recombinant viral vector, e.g., rAAV vector encoding a lysosomal enzyme, having a lysosomal targeting IGF2(V43) sequence that binds human cation-independent mannose-6-phosphate receptor (CI-MPR) or to the IGF2 receptor, permitting proper subcellular localization of the lysosomal enzyme polypeptide to lysosomes. Also encompassed are therapeutic fusion proteins encoded by the viral vector, non-viral vectors, cells, and methods to treat a glycogen storage disease, e.g., those listed in Table 4A or Table 5A with the viral vector.

Abstract: Recombinant AAV (rAAV) vectors comprising a rAVV genome comprising a heterologous nucleic acid encoding a signal peptide and optionally a IGF-2 sequence, fused to an acid alpha-glucosidase (GAA) polypeptide, enabling the GAA polypeptide to be secreted from the liver and targeted to the lysosomes. Particular embodiments relate to a recombinant AAV (rAAV) vector encoding an alpha-glucosidase (GAA) polypeptide, having a liver secretory signal peptide and a targeting IGF2 sequence that binds human cation-independent mannose-6-phosphate receptor (CI-MPR) or to the IGF2 receptor, permitting proper subcellular localization of the GAA polypeptide to lysosomes. Also encompassed are cells, and methods to treat a glycogen storage disease type II (GSD II) disease and/or Pompe Disease with the rAAV vector.

Abstract: Sensors and methods for determining the state of charge of a battery are described. The state of charge is determined in some instances by applying a current perturbation having a frequency to the battery terminals, monitoring the response signal, and determining the phase of the response signal. The phase may be correlated to the state of charge of the battery, so that once the phase is determined, a determination of the state of charge of the battery may be made. In some situations, the state of charge may be used to determine the operating condition of a load connected to the battery. In some embodiments, the state of charge may be used to determine whether the battery is defective.

Abstract: Aspects of this disclosure relate to detecting a header of a packet. A receive signal path can provide a receive signal that includes packets and a guard preamble between successive packets of the packets. A receiver control circuit can trigger a timer that sets a time for detecting a header of a packet in response to detecting an end of a preamble of the packet.

Abstract: Aspects of this disclosure relate to transmitting and/or receiving a frequency-shift keying signal including a packet that includes a preamble and a payload. The preamble has a first modulation index that has a smaller magnitude than a second modulation index of the payload. This can enhance frequency correction in a receive device that receives the packet.

Abstract: Aspects of this disclosure relate to detecting a header of a packet. A receive signal path can provide a receive signal that includes packets and a guard preamble between successive packets of the packets. A receiver control circuit can trigger a timer that sets a time for detecting a header of a packet in response to detecting an end of a preamble of the packet.

Abstract: Aspects of this disclosure relate to transmitting and/or receiving a frequency-shift keying signal including a packet that includes a preamble and a payload. The preamble has a first modulation index that has a smaller magnitude than a second modulation index of the payload. This can enhance frequency correction in a receive device that receives the packet.

Abstract: Aspects of this disclosure relate to active antenna calibration. In some embodiments, a local oscillator signal can be injected into the receive path for misalignment measurement and calibration of the receive path, a transmit signal from a transmit path can be coupled to a receive path, and the transmit path can be calibrated relative to the receive path.

Abstract: Aspects of this disclosure relate to active antenna calibration. In some embodiments, a local oscillator signal can be injected into the receive path for misalignment measurement and calibration of the receive path, a transmit signal from a transmit path can be coupled to a receive path, and the transmit path can be calibrated relative to the receive path.

Abstract: A projection subsystem includes a light engine that provides a collection lens, a collimator and at least one solid state light emitter. A projection lens assembly receives the image and provides a projection beam having a luminous flux level. The projection subsystem has a portability efficacy.

Abstract: A projection subsystem includes a light engine that provides a collection lens, a collimator and at least one solid state light emitter. A projection lens assembly receives the image and provides a projection beam having a luminous flux level. The projection subsystem has a portability efficacy.

Abstract: A projection subsystem includes a light engine that provides a collection lens, a collimator and at least one solid state light emitter. A projection lens assembly receives the image and provides a projection beam having a luminous flux level. The projection subsystem has a portability efficacy.