Patents by Inventor Michael W.W. Adams
Michael W.W. Adams has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10227617Abstract: Provided herein are genetically engineered microbes that include at least a portion of a carbon fixation pathway, and in one embodiment, use molecular hydrogen to drive carbon dioxide fixation. In one embodiment, the genetically engineered microbe is modified to convert acetyl CoA, molecular hydrogen, and carbon dioxide to 3-hydroxypropionate, 4-hydroxybutyrate, acetyl CoA, or the combination thereof at levels greater than a control microbe. Other products may also be produced. Also provided herein are cell free compositions that convert acetyl CoA, molecular hydrogen, and carbon dioxide to 3-hydroxypropionate, 4-hydroxybutyrate, acetyl CoA, or the combination thereof. Also provided herein are methods of using the genetically engineered microbes and the cell free compositions.Type: GrantFiled: January 19, 2017Date of Patent: March 12, 2019Assignees: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC., NORTH CAROLINA STATE UNIVERSITYInventors: Michael W. W. Adams, Robert M. Kelly, Aaron B. Hawkins, Angeli Lal Menon, Gina Lynette Pries Lipscomb, Gerrit Jan Schut
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Publication number: 20170226542Abstract: Provided herein are genetically engineered microbes that include at least a portion of a carbon fixation pathway, and in one embodiment, use molecular hydrogen to drive carbon dioxide fixation. In one embodiment, the genetically engineered microbe is modified to convert acetyl CoA, molecular hydrogen, and carbon dioxide to 3-hydroxypropionate, 4-hydroxybutyrate, acetyl CoA, or the combination thereof at levels greater than a control microbe. Other products may also be produced. Also provided herein are cell free compositions that convert acetyl CoA, molecular hydrogen, and carbon dioxide to 3-hydroxypropionate, 4-hydroxybutyrate, acetyl CoA, or the combination thereof. Also provided herein are methods of using the genetically engineered microbes and the cell free compositions.Type: ApplicationFiled: January 19, 2017Publication date: August 10, 2017Inventors: Michael W.W. Adams, Robert M. Kelly, Aaron B. Hawkins, Angeli Lal Menon, Gina Lynette Pries Lipscomb, Gerrit Jan Schut
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Patent number: 9587256Abstract: Provided herein are genetically engineered microbes that include at least a portion of a carbon fixation pathway, and in one embodiment, use molecular hydrogen to drive carbon dioxide fixation. In one embodiment, the genetically engineered microbe is modified to convert acetyl CoA, molecular hydrogen, and carbon dioxide to 3-hydroxypropionate, 4-hydroxybutyrate, acetyl CoA, or the combination thereof at levels greater than a control microbe. Other products may also be produced. Also provided herein are cell free compositions that convert acetyl CoA, molecular hydrogen, and carbon dioxide to 3-hydroxypropionate, 4-hydroxybutyrate, acetyl CoA, or the combination thereof. Also provided herein are methods of using the genetically engineered microbes and the cell free compositions.Type: GrantFiled: September 6, 2013Date of Patent: March 7, 2017Assignees: University of Georgia Research Foundation, Inc., North Carolina State UniversityInventors: Michael W. W. Adams, Robert M. Kelly, Aaron B. Hawkins, Angeli Lal Menon, Gina Lynette Pries Lipscomb, Gerrit Jan Schut
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Patent number: 9249440Abstract: Provided herein are polypeptides having hydrogenase activity. The polypeptide may be multimeric, and may have hydrogenase activity of at least 0.05 micromoles H2 produced min?1 mg protein?1. Also provided herein are polynucleotides encoding the polypeptides, genetically modified microbes that include polynucleotides encoding one or more subunits of the multimeric polypeptide, and methods for making and using the polypeptides.Type: GrantFiled: March 11, 2014Date of Patent: February 2, 2016Assignee: University of Georgia Research Foundation, Inc.Inventors: Michael W. W. Adams, Robert C. Hopkins, Francis E. Jenney, Jr., Junsong Sun
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Publication number: 20150275238Abstract: Disclosed herein are genetically engineered microbes. In one embodiment, a genetically engineered microbe includes a metabolic pathway for the production of an alcohol from an organic acid. For instance, a genetically engineered microbe converts acetate, butyrate, propionate, isobutyrate, valerate, isovalerate, caproate, or phenylacetate, to Ethanol, Butanol, Propanol, Isobutanol, 1-Pentanol, Isoamylalcohol, 1-Hexanol, Phenylethanol, respectively. Also provided herein are methods of using the microbes.Type: ApplicationFiled: March 27, 2015Publication date: October 1, 2015Inventors: Robert M. Kelly, Michael W.W. Adams, Gerrit J. Schut, Mirko Basen
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Publication number: 20150211030Abstract: Provided herein are genetically engineered microbes that include at least a portion of a carbon fixation pathway, and in one embodiment, use molecular hydrogen to drive carbon dioxide fixation. In one embodiment, the genetically engineered microbe is modified to convert acetyl CoA, molecular hydrogen, and carbon dioxide to 3-hydroxypropionate, 4-hydroxybutyrate, acetyl CoA, or the combination thereof at levels greater than a control microbe. Other products may also be produced. Also provided herein are cell free compositions that convert acetyl CoA, molecular hydrogen, and carbon dioxide to 3-hydroxypropionate, 4-hydroxybutyrate, acetyl CoA, or the combination thereof. Also provided herein are methods of using the genetically engineered microbes and the cell free compositions.Type: ApplicationFiled: September 6, 2013Publication date: July 30, 2015Applicant: North Carolina State UniversityInventors: Michael W.W. Adams, Robert M. Kelly, Aaron B. Hawkins, Angeli Lal Menon, Gina Pries Lipscomb, Gerrit Jan Schut
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Patent number: 8927254Abstract: Provided herein are methods for transforming a Pyrococcus furiosus with a polynucleotide. In one embodiment, the method includes contacting a P. furiosus with a polynucleotide under conditions suitable for uptake of the polynucleotide by the P. furiosus, and identifying transformants at a frequency of, for instance, at least 103 transformants per microgram DNA. Also provided are isolated Pyrococcus furiosus having the characteristics of Pyrococcus furiosus COM1, and plasmids that include an origin of replication that functions in a Pyrococcus furiosus. The plasmid is stable in a recipient P. furiosus without selection for more than 100 generations and is structurally unchanged after replication in P. furiosus for more than 100 generations.Type: GrantFiled: September 29, 2011Date of Patent: January 6, 2015Assignee: University of Georgia Research Foundation, Inc.Inventors: Gina L. Lipscomb, Joel Andrew Farkas, Michael W. W. Adams, Janet Westpheling
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Publication number: 20140308700Abstract: Provided herein are polypeptides having hydrogenase activity. The polypeptide may be multimeric, and may have hydrogenase activity of at least 0.05 micromoles H2 produced min?1 mg protein?1. Also provided herein are polynucleotides encoding the polypeptides, genetically modified microbes that include polynucleotides encoding one or more subunits of the multimeric polypeptide, and methods for making and using the polypeptides.Type: ApplicationFiled: March 11, 2014Publication date: October 16, 2014Applicant: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.Inventors: MICHAEL W.W. ADAMS, ROBERT C. HOPKINS, FRANCIS E. JENNEY, JR., JUNSONG SUN
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Publication number: 20140248687Abstract: Provided herein are genetically engineered archaea. A genetically engineered archaea includes a heterologous polynucleotide that has a promoter operably linked to a coding region, where the coding region encodes a polypeptide having optimal activity below the optimum growth temperature (Topt) of the genetically engineered archaeon. Also provided herein are methods for using genetically engineered archaea and cell-free extracts of such genetically engineered archaea. In one embodiment, the methods include culturing a genetically engineered archaeon at a temperature that is at least 20° C. below the Topt of the genetically engineered archaeon, such that the activity in the genetically engineered archaeon of a polypeptide encoded by the coding region is increased compared to the activity in the genetically engineered archaeon of the polypeptide during growth at a second temperature that is at or near the Topt of the genetically engineered archaeon.Type: ApplicationFiled: November 2, 2012Publication date: September 4, 2014Applicants: University of Georgia Research Foundation, Inc., North Carolina State UniversityInventors: Robert M. Kelly, Michael W.W. Adams, Mirko Basen, Gina Pires Lipscomb, Angeli Menon
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Publication number: 20130102022Abstract: Provided herein are plants having altered expression of a GAUT polypeptide. Such plants have phenotypes that may include decreased recalcitrance, increased growth, decreased lignin content, or a combination thereof. Also provided herein are methods of making and using such plants.Type: ApplicationFiled: April 15, 2011Publication date: April 25, 2013Applicant: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.Inventors: Debra A. Mohnen, Ajaya Kumar Biswal, Zhangying Hao, Kimberly D. Hunt, Ivana Gelineo-Albersheim, Irina Kataeva, Michael W.W. Adams
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Publication number: 20120135411Abstract: Provided herein are methods for transforming a Pyrococcus furiosus with a polynucleotide. In one embodiment, the method includes contacting a P. furiosus with a polynucleotide under conditions suitable for uptake of the polynucleotide by the P. furiosus, and identifying transformants at a frequency of, for instance, at least 103 transformants per microgram DNA. Also provided are isolated Pyrococcus furiosus having the characteristics of Pyrococcus furiosus COM1, and plasmids that include an origin of replication that functions in a Pyrococcus furiosus. The plasmid is stable in a recipient P. furiosus without selection for more than 100 generations and is structurally unchanged after replication in P. furiosus for more than 100 generations.Type: ApplicationFiled: September 29, 2011Publication date: May 31, 2012Inventors: Gina L. Lipscomb, Joel Andrew Farkas, Michael W.W. Adams, Janet Westpheling
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Publication number: 20110217740Abstract: Disclosed herein are methods of degrading plant biomass, and microorganisms and polypeptides used in such methods, hi certain embodiments, the methods include growing Anaerocellum thermophilum on a substrate that comprises plant biomass under conditions effective for the A. thermophilum to convert at least a portion of the plant biomass to a water soluble product or a water insoluble product, hi some cases, the method can further include one or more steps to further process the water soluble product or a water insoluble product to produce, for example, a biofuel or commodity chemical. In another aspect, microorganisms that include at least one A. thermophilum plant biomass utilization polynucleotide are disclosed. Also disclosed are methods of transferring one or more A. thermophilum plant biomass utilization polynucleotides to a recipient microorganism. A. thermophilum plant biomass utilization polynucleotides and polypeptides encoded by such polynucleotides are also disclosed.Type: ApplicationFiled: August 26, 2009Publication date: September 8, 2011Applicant: University of Georgia ResearchInventors: Michael W.W. Adams, Janet Westpheling, Scott Hamilton-Brehm, Irina Kataeva, Sung-Jae Yang, Farris Poole
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Publication number: 20110020875Abstract: Provided herein are polypeptides having hydrogenase activity. The polypeptide may be multimeric, and may have hydrogenase activity of at least 0.05 micromoles H2 produced min?1 mg protein?1. Also provided herein are polynucleotides encoding the polypeptides, genetically modified microbes that include polynucleotides encoding one or more subunits of the multimeric polypeptide, and methods for making and using the polypeptides.Type: ApplicationFiled: December 5, 2008Publication date: January 27, 2011Applicant: University of Georgia Research Foundation, Inc.Inventors: Michael W.W. Adams, Francis E. Jenney, JR., Junsong Sun, Robert C. Hopkins