Abstract: An inner mandrel for forming a variable taper component includes a plurality of interlocking pieces and a brace. Each interlocking piece defines opposed tapered edge faces, a first surface, and a tapered second surface opposite the first surface. One of the edge faces defines a locking feature and another of the edge faces defines a receiving feature engaging the locking feature of an adjacent interlocking piece. The first surface defines a variable taper and a plurality of recesses. The brace secures the plurality of interlocking pieces to each other in a concentric arrangement about a central axis. A maximum width of each of the interlocking pieces is smaller than a minimum width of an end portion of the variable taper component. A central portion of the variable taper component is wider than the end portions.

Abstract: The present invention relates to a method for producing a liquid composition comprising a nanoparticle comprising at least one RNA and at least one cationic or polycationic compound, advantageously on a large scale suitable for pharmaceutical applications. The present invention further concerns the use of the inventive method in the manufacture of a medicament or a vaccine. Furthermore, the invention relates to compositions containing the RNA-comprising nanoparticle, and to pharmaceutical compositions comprising the same.

Abstract: A filter element for filtering a fluid has a frame and a filter bellows provided with a filter medium folded in a zigzag shape to folds. The filter bellows has an inflow face at a raw side of the filter bellows and an outflow face at a clean side of the filter bellows. The filter bellows is arranged in the frame. A seal is arranged circumferentially at least partially continuously at least in sections at an outer circumferential side of the filter medium at the inflow face of the filter bellows or at the outflow face of the filter bellows. Elongate adhesive sections are arranged along at least two adhesive tracks on the filter medium at the inflow face of the filter bellows and/or at the outflow face of the filter bellows. Strain-relief devices for compensating a length change of the at least two adhesive tracks in relation to the filter medium and/or to the seal are provided. A filter system is provided with such a filter element.

Abstract: The invention relates to a method for detecting a measured value (d?/dx, M).

Abstract: The present invention relates to a method for establishing a cell bank, comprising the steps of providing a batch of cell suspension comprising stem cells or stem cell-derived cells, and a cryopreservation medium, maintaining the batch of cell suspension at a temperature below 15° C., and transferring an amount of the cell suspension from the batch of cell suspension into one or more storage containers, wherein establishing the cell bank takes at least (30) minutes.

Abstract: The invention provides a method and apparatus for acquisition and analysis of data that displays a linear relationship or can be transformed into a linearized relationship, such as electrophysiological signal data from sensors such as those suitable for EEG, MEG, ECG and the like.

Abstract: Systems and methods provide real-time shipping optimization recommendations for reducing the cost of shipping freight units in a shipment. System comprises a measurement system in communication with a computer system that comprises a client computer device in communication with a host computer system. The measurement system comprises multiple sensing devices to determine weight, dimensions, and other shipping parameters of the freight units in the shipment. The computer system computes a current shipping cost and density based on the shipping parameters. The computer system determines shipping recommendations including recommended adjustments to the shipping parameters that reduce the current shipping cost. The shipping recommendations are transmitted to the client computer device prior to loading the shipment onto a carrier vehicle for the shipment.

Abstract: Systems and methods are disclosed for a method of production of carbon nanochain, for use as cathodes, either alone or in combination with multi-walled carbon nanotubes. The carbon nanochain precursors are heated in the presence of inert atmosphere to synthesize the carbon nanochains. The carbon nanochains have high gravimetric and volumetric capacity and good cycle life when used as cathodes in Li—O2 batteries. The performance of Li—O2 battery cathodes comprised of mixtures of carbon nanochains and multiwalled carbon nanotubes is dramatically improved relative to cathodes comprised of either material in the absence of the other.

Abstract: System and method configured to determine a direction of movement of a vehicle in response to a brake being released or in response to initiating movement of the vehicle from a stopped position along a route. The direction of movement is determined based on a selected travel direction of the vehicle, a grade of the route, and at least one of applied tractive efforts or applied braking efforts.

Abstract: A method for upgrading a gas turbine, the method includes: a) removing all guide vanes of the first guide vane stage; b) replacing the removed guide vanes of the first guide vane stage with new or reconditioned guide vanes, wherein blade platforms of the new or reconditioned guide vanes are provided with cooling air bores which fluidically connect a cooling air supply duct to the annular gap and open into the annular gap, and wherein the cooling air bores are arranged in such a manner that more cooling air bores open into regions of an annular gap that are arranged radially inwards from leading edges of the guide vanes than in other regions of the annular gap.

Abstract: A flexibly deformable chain that includes connectors for electrical contacting. Each of the connectors can include a first component in which electrically conductive contacts can be retained. The first component can be made from a fire-retardant plastic. Additionally, a second component can allow mechanical connection of each of the connectors in the flexibly deformable chain. The second component can have an ignition point which is lower than an ignition point of the first component and the second component can have an elasticity which is greater than an elasticity of the first component.

Abstract: A risk management method, system, and non-transitory computer readable medium, include a data analyzing circuit configured to analyze user data, site data, and equipment data to map prior behavior types to an event on a site, a relationship determining circuit configured to determine a relationship between the mapped data and the event based on behaviors exhibited by the user and an impact on a performance factor and a risk factor, and a reinforcement learning circuit configured to use reinforcement learning to learn the performance factor to the risk factor ratio to optimize an overall site productivity.

Abstract: Tourniquets have an elongated body having opposed first and second anchor locations, a strap having a body end connected to and extending from the first anchor location of the body, the strap having a free end, the second anchor location of the body having an adjustor buckle defining a passage receiving an intermediate portion of the strap between the body end and the free end, the adjustor buckle configured to resist movement of the strap through the passage in response to tension applied between the body and the portion of the strap extending toward the body end, and to enable movement of the strap through the passage in response to tension applied between the elongated body and a tail portion of the strap extending from the intermediate portion to the free end, the elongated body having a tightener, and the tail portion being connected to the elongated body.

Abstract: There is provided a composition comprising: (i) a compound of Formula I: (I), or a pharmaceutically acceptable salt thereof, and (ii) a nuclide M, or a pharmaceutically acceptable salt of the compound of Formula I and/or the nuclide M, wherein C is a chelator selected from the group consisting of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA), 1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA), 1,4,8,11-tetraazacycl otetradecane-1,4,8,11-tetraacetic acid (TETA), diethylenetriaminepentaacetic acid (DTPA), desferrioxamine B (DFO), 1,4,7-Triazacyclononane-1-glutaric acid-4,7-acetic acid (NOTAGA), 2-[4,7,10-Tris(carboxymethyl)-1,4,7,10-tetraza-1-cyclododecyl]glutaric acid (DOTAGA and a derivative of any one of the foregoing chelators, L (Formula L) is a linker: (L), wherein m is an integer within the range of from 1 to 20, and X is NH or C(O) and forms an amide bond, i.e.

Abstract: A connector for electrical contacting that includes a body configured to mechanically retain at least one electrically conductive contact, which is accessible on an exit side of the body for electrically contacting at least one other electrical contact. The body is constructed from at least two different components, with a first component of the at least two different components at least substantially forming the exit side and being made from a fire-retardant plastic, and a second component of the at least two different components having an ignition point which is lower than an ignition point of the first component of the at least two components, and the second component of the at least two different components having an elasticity which is greater than an elasticity of the first component of the at least two different components.

Abstract: The invention relates to a control system for controlling a brake, a steering and/or a drive of an autonomous or automated vehicle. This involves an artificial-intelligence-based first control apparatus being monitored by virtue of a criticality of a driving situation being determined on the basis of simple calculation values, wherein a specific criticality of the driving situation, or an inappropriate reaction by the first control apparatus to the driving situation, can result in changeover to a second control apparatus that undertakes the control of the vehicle on the basis of a deterministic calculation rule.

Abstract: A method of manufacturing a complex-shaped metal part, including the steps of applying a metallic sheath around a sheet metal workpiece and applying an electric current through the workpiece in the metallic sheath to heat the workpiece. The method also includes shaping the workpiece in the metallic sheath into a complex-shaped metal part while it is being heated. The shaping can be performed between two ceramic dies or using other techniques for forming complex shapes and curvatures into the workpiece. The method then may include cooling the complex-shaped metal part and removing the metallic sheath from the complex-shaped metal part. This method can allow reactive and refractory material to be safely heated without oxidation when heating/forming in air when the workpiece is sealed within a sacrificial stainless steel or nickel alloy envelope to protect the enclosed workpiece.

Abstract: A method of bonding two or more metallic components into a single piece. The bonding surfaces of the metallic components are protected from reaction with the environment. A force is applied to the metallic components to push the bonding surfaces together. Simultaneous with applying the force, an electric current is passed through the bonding surfaces to joule heat and weld the bonding surfaces together to form the single piece. The bonding surfaces may be protected by plating with a noble metal, applying a coating, shielding with a noble gas, or placing into a vacuum. A press may be used to apply the force. The force and the electric current may be sufficient to push out metal around the joint of the bonding surfaces, and at least one of the bonding surfaces may be drafted to facilitate pushing out the metal. The electric current may be pulsed to induce electroplasticity.

Abstract: A protective device for protecting the cervical spine includes a first damping device having a sheath and a first chamber. The protective device further includes a bracing device. The bracing device is configured to brace, in a damped manner, a pulse-like force transmission, induced by contact of a protective helmet with a first contact surface of the first damping device, to the first damping device, directly or indirectly, against the upper body of a person. A gaseous or liquid or gel-like first damping medium is disposed in the first chamber of the first damping device.

Abstract: The present invention relates to GIP(1-30) analogues which selectively bind and activate the GIP receptor and comprise a chelating moiety capable of binding a metal ion and their use, for example in PET imaging or for radiotherapy.