Abstract: The disclosure is directed to novel predictive methods and personalized therapies for treating dry eye disease (DED). Specifically, this disclosure relates to methods of treating a patient having DED by selectively administering a TNF? antagonist, e.g., a TNF? antibody, such as LME636, to the patient on the basis of that patient being genetically predisposed to have a favorable response to treatment with the TNF? antagonist. Also disclosed herein are transmittable forms of information, diagnostic methods, and kits useful in predicting the likelihood that a patient having DED will respond to treatment with a TNF? antagonist, e.g., a TNF? antibody, such as LME636.

Abstract: The disclosure is directed to novel predictive methods and personalized therapies for treating dry eye disease (DED). Specifically, this disclosure relates to methods of treating a patient having DED by selectively administering a TNF? antagonist, e.g., a TNF? antibody, such as LME636, to the patient on the basis of that patient being genetically predisposed to have a favorable response to treatment with the TNF? antagonist. Also disclosed herein are transmittable forms of information, diagnostic methods, and kits useful in predicting the likelihood that a patient having DED will respond to treatment with a TNF? antagonist, e.g., a TNF? antibody, such as LME636.

Abstract: The disclosure is directed to novel predictive methods and personalized therapies for treating dry eye disease (DED). Specifically, this disclosure relates to methods of treating a patient having DED by selectively administering a TNF? antagonist, e.g., a TNF? antibody, such as LME636, to the patient on the basis of that patient being genetically predisposed to have a favorable response to treatment with the TNF? antagonist. Also disclosed herein are transmittable forms of information, diagnostic methods, and kits useful in predicting the likelihood that a patient having DED will respond to treatment with a TNF? antagonist, e.g., a TNF? antibody, such as LME636.

Abstract: A role playing game having a plurality of character cards with a surface on which a character summary is written and includes at least a Character Name, Character Information, and Character Abilities, a board having a status bar with indicators that can slide between actions, a dodge meter that can move to indicate a number of dodges available, a stamina wheel that can rotate to indicate a number of stamina points available, a character spot for accepting a character card, a Solo Defense Bar with indicators to indicate a number of defense points available, a Team Defense Bar with indicators that can slide to indicate a number of defense points available, and an Enhancement Bar with an indicator that can slide to indicate a number of lives remaining or a value of enhancement points, a plurality of Numbered Ability Cards and Special Ability Cards.

Abstract: Techniques for electronic signature processes are described. Some embodiments provide an electronic signature service (“ESS”) configured to facilitate the creation, storage, and management of electronic signature documents. The ESS may facilitate payment processing via an electronic signature document that includes or is associated with a payment form. When the signature document is presented to a user for signature, the payment form collects payment data (e.g., card type, account number, name) that is used by the ESS to process payment upon completion of the signing process.

Abstract: The invention relates to a sensor device (1) for measuring an axial force in the longitudinal pipe direction of a pipe (4) and/or at least one torque, having a measuring element (2) comprising an adapter connection (3) connected to the pipe by means of a flanged socket part, by means of which the pipe can be fixedly coupled to an adjustment adapter (5), wherein the axial force and the torque can be fed into the adjustment adapter and can be measured by means of strain gauges (11, 12) disposed in a sensor area (9) between the adapter connection and an end of the flanged socket part (6) opposite the adapter connection at strain gauge locations, wherein the flanged socket part having the sensor area is designed in a pipe shape, wherein the sensor area extends from the adapter connection to the end of the flanged socket part and has a smaller outer diameter than the end of the flanged socket part, wherein the end of the pipe facing the adapter connection and extending past the end of the flanged socket part towar

Abstract: The invention relates to a sensor device (1) for measuring an axial force in the longitudinal pipe direction of a pipe (4) and/or at least one torque, having a measuring element (2) comprising an adapter connection (3) connected to the pipe by means of a flanged socket part, by means of which the pipe can be fixedly coupled to an adjustment adapter (5), wherein the axial force and the torque can be fed into the adjustment adapter and can be measured by means of strain gauges (11, 12) disposed in a sensor area (9) between the adapter connection and an end of the flanged socket part (6) opposite the adapter connection at strain gauge locations, wherein the flanged socket part having the sensor area is designed in a pipe shape, wherein the sensor area extends from the adapter connection to the end of the flanged socket part and has a smaller outer diameter than the end of the flanged socket part, wherein the end of the pipe facing the adapter connection and extending past the end of the flanged socket part towar

Abstract: A force sensor with two force input elements to which the force to be measured and the support force are applied. The two force input elements are substantially rotationally symmetrical and are axially spaced apart, and the force to be measured and the support force are applied in a radial direction. A spring element, arranged axially between the two force input elements connects these elements and its load-dependent deformation is converted into an electrical signal. A substantially tubular cover connected to one of the two force input elements surrounds the spring element. The cover surrounds a portion of the other force input element, forming a circumferential gap. The cover has an inwardly projecting constriction that is spaced apart by a small axial distance from an opposite shoulder on the other force input element.

Abstract: A force sensor with two force input elements to which the force to be measured and the support force are applied. The two force input elements are substantially rotationally symmetrical and are axially spaced apart, and the force to be measured and the support force are applied in a radial direction. A spring element, arranged axially between the two force input elements connects these elements and its load-dependent deformation is converted into an electrical signal. A substantially tubular cover connected to one of the two force input elements surrounds the spring element. The cover surrounds a portion of the other force input element, forming a circumferential gap. The cover has an inwardly projecting constriction that is spaced apart by a small axial distance from an opposite shoulder on the other force input element.

Abstract: A laser signal coupling device one embodiment of which comprises a transmitter where a laser diode is coupled to a single mode fiber optic cable through the use of a lens whose position relative the diode is kept constant but whose length is adjusted to obtain a beam waist for the focused beam at some predefined point such as inside the end of the fiber optic cable. Such a positioning of the beam waist can increase the yield by reducing the effect of alignment variations in axial, radial and angular directions as well as reduce noise from fiber end surface reflections. The same concept may be used to accurately focus signaling received from an optic cable, in a surface of a signal detector. Further, the concept may be used for focusing between optic cable of different types such as converting from multi-mode to single-mode fiber optic cable.

Abstract: An electro-optical module for facilitating connection between a fiber optic cable connector and an electrical circuit includes an interlocking tongue-and-groove design between the skirts of the module and an electro-optical active device. Within the electro-optical active device, a lens provides hermetic sealing to the case so as to eliminate the requirement for an additional window. A barrel providing partial enclosure for the lens is used to facilitate alignment with the fiber optic cable. Finally, the total module includes mechanisms so that exact spacing is obtained between the light source and the end of the fiber optic cable whereby the beam waist of the light when the device is used in the transmission mode occurs interior to the cable rather than at the surface to accommodate manufacturing tolerances, bending forces and to reduce noise generated by reflections, etc.

Abstract: In apparatus for charging and discharging substrates, substrates are disposed in a magazine or substance store and into the pre-chamber of a high-vacuum-processing-chamber which is made as a vacuum chamber, the magazine being pushed into a housing, which at its lower side provides an opening. The housing can be deposited with the magazine onto the upper part of the wall of the lower box, an air lock plate held below an opening in the upper part of the wall taking the magazine and lowering it into a lower position by means of a pair of lifting cylinders. After this the air lock plate with the magazine and the pair of lifting cylinders are movable laterally on a conveying-slide-carriage, until the air lock plate is positioned below the passage of opening in the bottom part of the vacuum chamber. Eventually the air lock plate can be moved so far up in a vertical direction, until the magazine is disposed in the pre-chamber and until the air lock plate, which is a little bigger, closes the opening of passage.

Abstract: In an apparatus for passing a discoidal workpiece into and out of a coating chamber through a lock and for shifting the workpiece into and out of the range of a coating source, a swivelling arm is journaled for movement about a vertical axis on the top of the coating chamber. The ends of the swiveling arm have jacks bearing workpiece holding plates which transport the workpiece to an opening in the coating chamber. The workpiece holders are adapted to close off the opening from above. A turntable which can swivel about a vertical axis in the interior of the coating chamber has recesses on its top side for accommodating the workpieces. Lifting plates are journaled in these recesses and can be raised and lowered by lifting means in the bottom plate.