Abstract: Aspects and embodiments herein pertain to global ML prediction applied in a data security context. In some examples, a global prediction pertaining to a data item as a whole (the ‘original’ data item) is generated using an ML predictor. A data element is masked by removing it from the data item, or obscuring it in some way (e.g., through modification or replacement). The same ML predictor is applied to the perturbed data item. A change in global confidence between the original data item and the perturbed data item denotes local significance of the individual data item (or subset of data items) that have been masked. Other significance indicators (such as start and end markers of significant sections) are also considered. Other methods of estimating local significance are considered. In some examples, one or more such methods are used to generate training data for training a self-interpretation ML model.

Abstract: A gas turbine engine comprises a compressor section, a combustion section, and a turbine section in a serial flow arrangement and enshrouded by a casing, the combustion section comprising: an annular combustion chamber defined by at least a dome wall and an annular liner; a plurality of combustor cups circumferentially arranged on the dome wall; a fuel supply connected to the casing; and a fuel nozzle passing through the casing and having a nozzle tube and a distribution manifold fluidly coupling the nozzle tube to at least two combustor cups of the plurality of combustor cups; wherein the fuel nozzle is fixed to the at least two combustor cups.

Abstract: Described are methods of dephosphorylation. Methods of dephosphorylation include contacting a phosphate containing substrate with one or more CeO2 nanocrystal. Also described is modifying the pH of the dephosphorylation reaction to affect the amount and rate of dephosphorylation. Further described are methods of making CeO2 nanocrystals of the present disclosure.

Abstract: The present disclosure provides for compounds of formula (I) wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of formula (I).

Abstract: The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of PI3K? enzymes with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with PI3K? signaling with the compounds and compositions of the disclosure.

Abstract: Provided is a system for analyzing features associated with entities using an embedding tree, the system including at least one processor programmed or configured to receive a dataset associated with a plurality of entities, wherein the dataset comprises a plurality of data instances for a plurality of entities. The processor may be programmed or configured to generate at least two embeddings based on the dataset and determine split criteria for partitioning an embedding space of at least one embedding tree associated with the dataset based on feature data associated with an entity and embedding data associated with the at least two embeddings. The processor may be programmed or configured to generate at least one embedding tree having a plurality of nodes based on the split criteria. Methods and computer program products are also provided.

Abstract: An integrated fuel cell and combustor assembly includes a combustor that is fluidly coupled with at least one upstream compressor that generates compressed air. A fuel cell stack having a cathode and an anode is fluidly coupled to the combustor. The fuel cell stack is configured to receive intake fuel and a portion of the compressed air as intake air, to generate a fuel cell power output using the intake fuel and the intake air, and to direct a fuel and air exhaust from the fuel cell stack into the combustor. A self-reliant air supply system is fluidly coupled with the at least one upstream compressor and the fuel cell stack, and is configured to supply the intake air to the fuel cell stack. A fault-tolerant controller is configured to detect a transient event within the combustor and to control the self-reliant air supply system during the transient event.

Abstract: In an illustrative embodiment, systems and methods for monitoring insurance claims include identifying, based on predetermined monitoring frequency, insurance claims identified for vulnerability detection processing. Vulnerability detection features may be extracted from data files of the claims, which provide an indication of claim handling deficiencies that can cause claim leakage. A trained vulnerability detection data model can be used to detect claim handling vulnerabilities within the extracted vulnerability detection features where each of the vulnerabilities may include a likelihood of the vulnerability resulting in claim leakage. The vulnerability detection data model may be trained with a data set customized to a respective insurance provider for each claim. Vulnerability scores indicating an overall likelihood of claim leakage can be calculated for the claims based on the detected claim handling vulnerabilities.

Abstract: Techniques are disclosed for facilitating the tuning of hyperparameter values during the development of machine learning (ML) models using visual analytics in a data science platform. In an example embodiment, a computer-implemented data science platform is configured to generate, and display to a user, interactive visualizations that dynamically change in response to user interaction. Using the introduced technique, a user can, for example, 1) tune hyperparameters through an iterative process using visual analytics to gain and use insights into how certain hyperparameters affect model performance and convergence, 2) leverage automation and recommendations along this process to optimize the tuning given available resources, 3) collaborate with peers, and 4) view costs associated with executing experiments during the tuning process.

Abstract: Disclosed are compounds of Formula (I), Formula (II), or a salt thereof: Formula (I) Formula (II) which compounds have properties for inhibiting Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula (I), Formula (II) or their salts, and methods of treating pain disorders, cough, and itch using the same.

Abstract: A method of producing reaction bonded silicon carbide (RB-SiC) ceramic components containing internal channels is described. In some embodiments, methods as described herein may utilize diamond powder at the interface of two or more preformed sections.

Abstract: Systems and methods for additive manufacturing are provided. In some embodiments, a method for additive manufacturing includes forming a portion of an additively manufactured object within a reservoir of curable material by scanning a plurality of energy beams of a plurality of energy sources through a plurality of respective scanning regions in the curable material. The scanning regions can overlap at one or more object locations, such that a combined energy dosage delivered to the one or more object locations by two or more of the energy beams is greater than or equal to a threshold dosage for solidifying the curable material. The method can further include advancing the reservoir of curable material relative to the energy sources. The forming and advancing processes can be repeated to fabricate the additively manufactured object.

Abstract: Hierarchical Power Management (HPM) architecture considers the limits of scaling on a power management controller, the autonomy at each die, and provides a unified view of the package to a platform. At a simplest level, HPM architecture has a supervisor and one or more supervisee power management units (PMUs) that communicate via at least two different communication fabrics. Each PMU can behave as a supervisor for a number of supervisee PMUs in a particular domain. HPM addresses these needs for products that comprise a collection of dice with varying levels of power and thermal management capabilities and needs. HPM serves as a unified mechanism than can span collection of dice of varying capability and function, which together form a traditional system-on-chip (SoC). HPM provides a basis for managing power and thermals across a diverse set of dice.

Abstract: A mobile device or a method performed by a mobile device for protecting user privacies by swapping IMEI values. The mobile device accesses an IMEI value stored by and corresponding to the mobile device, selects a managed IMEI value from a pool of candidate IMEI values, and replaces the IMEI value with the managed IMEI value. In response to receiving an IMEI request from a wireless entity, the mobile device provides the managed IMEI value to the wireless entity. In response to receiving an IMEI request from an authentication service, the mobile device provides the IMEI value corresponding to the mobile device to the authentication service.

Abstract: A system for dilating tissue includes a retractor having a pair of retractor blades that are movable towards and away from each other to retract tissue of a patient. The retractor blades have longitudinal guide channels. A first pin is attachable to a first vertebra. The system also includes an interbody spacer insertion device that has a guide channel for slidably engaging the longitudinal channel guide and is releasably attachable to an interbody spacer. The interbody spacer insertion device is configured to guide the interbody spacer into a space between adjacent vertebrae. A method for using the system includes advancing the retractor blades towards first and second vertebrae. The first retractor blade is attached to the first vertebra using the first pin and the retractor blades are moved away from each other. The interbody spacer insertion device is translated towards the vertebrae to position the interbody spacer between the vertebrae.

Abstract: Provided herein, inter alia, are compositions of short chain fatty acid (SCFA)-producing microorganisms and methods of making and using the same to inhibit pathogenic bacterial populations in the gastrointestinal tracts of an animal and additionally promote improvement of one or more metrics in an animal, such as increased bodyweight gain, decreased feed conversion ratio (FCR), improved gut barrier integrity, reduced mortality, reduced pathogen infection, and reduced pathogen shedding in feces.

Abstract: A combustion section defines an axial direction, a radial direction, and a circumferential direction. The combustion section includes a casing that defines a diffusion chamber. A combustion liner is disposed within the diffusion chamber and defines a combustion chamber the combustion liner is spaced apart from the casing such that a passageway is defined between the combustion liner and the casing. A fuel cell assembly is disposed in the passageway. The fuel cell assembly includes a fuel cell stack that has a plurality of fuel cells each extending between an inlet end and an outlet end. The inlet end receives a flow of air and fuel and the outlet end provides output products to the combustion chamber. The fuel cell assembly further includes an electrical circuit that is electrically coupled to the plurality of fuel cells and that extends through the casing.

Abstract: An example method includes receiving, by an SD-WAN system, WAN link characterization data for a plurality of WAN links of the SD-WAN system over a time period; and for each site of a plurality of sites of the SD-WAN system, generating, by the SD-WAN system, a local policy for the site, wherein generating the local policy is based on a machine learning model trained with the WAN link characterization data for the plurality of WAN links, and providing the local policy to an SD-WAN edge device of the site.

Abstract: A reaction-bonded silicon carbide (SiC) body is produced by: providing a preform including ceramic elements and carbon, and one or more surface features; providing a powder which includes diamond particles and carbon; locating the powder in the surface feature(s); and infiltrating the preform and the powder with molten silicon (Si) to form reaction-bonded SiC in the preform, and to form reaction-bonded SiC coatings on the diamond particles. The present disclosure also relates to a device/component which includes: a main body portion and discrete elements located at least partially within the main body portion. The main body portion may include reaction-bonded SiC and Si, but not diamond, while the discrete elements include diamond particles, reaction-bonded SiC coatings surrounding the diamond particles, and Si. According to the present disclosure, diamond may be advantageously located only where it is needed.

Abstract: A future financial metric is predicted using one or more computer processors. A financial metric prediction request is received from a user. Based on the financial metric prediction request, financial data is obtained. The financial data is inputted to one or more trained machine learning models. Using the one or more trained machine learning models, one or more preliminary predictions of the future financial metric are outputted. The one or more preliminary predictions of the future financial metric are inputted to a regression model. Using the regression model, a prediction of the future financial metric is generated.