Abstract: An opto-electronic device includes a substrate, a first electrode disposed over the substrate, a semiconducting layer disposed over the first electrode, a second electrode disposed over the semiconducting layer, the second electrode having a first portion and a second portion, a nucleation inhibition coating disposed over the first portion of the second electrode; and a conductive coating disposed over the second portion of the second electrode, wherein the nucleation inhibition coating is a compound of Formula (I)

Abstract: A method includes providing a zeolite material including a plurality of active sites. The plurality of active sites are bound to a plurality of hydrogen ions. The method includes exchanging at least a portion of the plurality of hydrogen ions with a plurality of copper ions, thereby forming a first amount of Z2Cu active sites that include copper (Cu2+) ions bound to the zeolite material and a first amount of ZCuOH active sites bound to copper hydroxide ions bound to the zeolite material. The method includes heating the zeolite material to a heat treatment temperature for a predefined time period to transform the zeolite material into a heat treated zeolite material. The heat treated zeolite material includes a second amount of Z2Cu active sites greater than the first amount of Z2Cu active sites and a second amount of ZCuOH active sites less than the first amount of ZCuOH active sites.

Abstract: The disclosure provides rocaglate acyl sulfamides (Roc ASFs), compositions and kits comprising same, and methods for their use.

Abstract: Described are a system, method, and computer program product for dynamic node classification in temporal-based machine learning classification models. The method includes receiving graph data of a discrete time dynamic graph including graph snapshots, and node classifications associated with all nodes in the discrete time dynamic graph. The method includes converting the discrete time dynamic graph to a time-augmented spatio-temporal graph and generating an adjacency matrix based on a temporal walk of the time-augmented spatio-temporal graph. The method includes generating an adaptive information transition matrix based on the adjacency matrix and determining feature vectors based on the nodes and the node attribute matrix of each graph snapshot.

Abstract: Bifunctional compounds, which find utility as modulators of leucine-rich repeat kinase 2 (LRRK2), are described herein. In particular, the hetero-bifunctional compounds of the present disclosure contain on one end a moiety that binds to the cereblon E3 ubiquitin ligase and on the other end a moiety which binds LRRK2, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The hetero-bifunctional compounds of the present disclosure exhibit a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aberrant regulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.

Abstract: A gas turbine engine is provided. The gas turbine engine includes a turbomachine having a compressor section, a combustor, and a turbine section arranged in serial flow order, the turbomachine further including an outer casing and, during operation of the gas turbine engine, an exhaust gas flow from the turbine section; and a fuel cell assembly positioned within the outer casing of the turbomachine, the fuel cell assembly having a fuel cell defining an inlet positioned to receive a portion of the exhaust gas flow, an outlet positioned to provide output products directly to the exhaust gas flow, or both.

Abstract: Compounds and methods of using said compounds singly or in combination with additional agents and compositions of said compounds for the treatment of cancer are disclosed.

Abstract: An inverter includes a DC input, a link capacitor including a plurality of input contacts fitted to a capacitor housing, a plurality of half-bridges, each including semiconductor switching elements for converting the DC current into an AC current having a plurality of phase currents, wherein the half-bridges are arranged in a row along a transverse direction to the inverter, a positive DC conductor rail and a negative DC conductor rail for the infeed of DC current to the half-bridges, wherein the positive and/or negative DC conductor rail extends in a transverse direction to the inverter over the row of half-bridges, such that the width of the positive and/or negative DC conductor rail extends to the width of the row of half-bridges, an AC conductor rail assembly for the output of AC current to the electric drive, and a cooler for cooling the half-bridges.

Abstract: Methods, systems, and computer program products are provided for coordinated analysis of output scores and input features of machine learning models in different environments. An example method includes receiving a plurality of first data records and a plurality of second data records. A first plot is generated based on a first score generated by a machine learning model for each first data record and a second score generated by the machine learning model for each second data record. The first plot is displayed. A plurality of second plots associated with at least a subset of the plurality of features are generated. Each respective second plot is generated based on a respective first field associated with a respective feature from the first data records and a respective second field associated with the respective feature from the second data records. The second plots are displayed.

Abstract: Examples herein provide an approach to enhance an audio mixture of a teleconference application by switching between noise suppression modes using a single model. Specifically, a machine learning (ML) model may be configured to, in response to receiving an audio mixture representation as input, suppress either a background noise of the audio mixture or suppress all noise of the audio mixture except a user's voice. In some examples, the ML model may be trained on speech and background noise training data during a training phase. In addition, the ML model may be trained on a user's voice during an enrollment phase. In addition, during an inference phase, the ML model may enhance the audio mixture by suppressing a portion of the audio mixture.

Abstract: A disposable cassette for detecting nucleic acids or performing other assays. The cassette can be inserted into a base station during use. The cassette has numerous features to ensure correct operation of the device under gravity, such as vent pockets for enabling the flow of sample fluid from one chamber to the next when the vent pocket is unsealed. The vent pockets have protrusions to help prevent accidental resealing. The cassette also can have a gasket to ensure free air movement between open vent pockets. A flexible circuit with patterned metallic electrical components disposed on a heat stable material can be in direct contact with fluid in the chambers and has resistive heating elements aligned with the vent pockets and the chambers.

Abstract: The present invention relates to bifunctional compounds, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins which are degraded and/or otherwise inhibited by bifunctional compounds according to the present invention. In particular, the present invention is directed to compounds, which contain on one end a VHL ligand which binds to the ubiquitin ligase and on the other end a moiety which binds a target protein such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of that protein. The present invention exhibits a broad range of pharmacological activities associated with compounds according to the present invention, consistent with the degradation/inhibition of targeted polypeptides.

Abstract: Some embodiments provide an irrigation flow sensor system, comprising: a housing forming a fluid channel to cooperate with conduits of an irrigation system; a paddle wheel device with at least a first blade of a set of the blades comprises a magnetic element; the paddle wheel device is positioned with at least a portion of the blades extends into the fluid channel as the blades rotate about an axis; a magnetic sensor proximate a pathway of the magnetic element as it rotates configured to provide a sensor output every time the magnetic element passes the magnetic sensor; a switch coupled to the magnetic sensor and a current loop, wherein the switch in an activate state is configured to temporarily change the current in the current loop in response to the sensor output, with a rate of change in current corresponding to a flow rate of the fluid flowing.

Abstract: Systems and methods are described to automate managing of relationships between IoT entities (e.g., devices, apps, users) and offloading the burden of managing these relationships from users. A Relationship Management Service (RM Service) is described herein for the autonomous establishment, modification, and tear-down of relationships between IoT entities.

Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, pharmaceutical compositions comprising the same, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.

Abstract: A WTRU may send a registration message to a first network node. The registration message may indicate a capability to perform a network performance prediction and may comprise information indicating AI operation types. The first network node which may determine whether the WTRU is permitted to request network performance prediction information. If the WTRU is permitted, the WTRU may send a packet data unit (PDU) session message that indicates a request to subscribe to network analytics associated with the AI operation types. A second network node may receive the PDU session message and may send a subscription message to a third network node. The subscription message may comprise, for example, the AI operation types. The second network node may receive a notification message that indicates information associated with the network analytics. The second network node may send to the WTRU a message indicating the information associated with the network analytics.

Abstract: The present disclosure relates generally to roofing systems. for example. suitable for covering the roof of a house or other building. The present disclosure relates more particularly to a roofing panel support including a bracket with a support platform configured to receive a roofing panel. a first leg extending rearward from a first side of the support platform, and a second leg extending rearward from a second side of the support platform. A hook for holding the roofing panel is coupled to the bracket and disposed below the support platform. Insulation may surround the hook. Additionally. a conductive malleable strip may be positioned between the bracket and a support structure.

Abstract: Proposed is a system for providing seamless communication between end DSDN nodes, such as satellites, unmanned aircraft systems (UAS), and base stations. These end DSDN nodes are connected with each other in a single global communication link. Each end DSDN node includes a smart routing system, and the system is configured to optimize routing paths to provide seamless connectivity by implementing advanced routing features, such as performance-enhancing proxy, quality of service, link aggregation, and link failure. In addition, the smart routing system can include a reprogrammable network processor and can reconfigure the network functionality of the end DSDN node by reconfiguring its functionality as a switch, proxy, or router based on the optimized routing paths.