Abstract: The present disclosure provides polymeric materials comprising semicrystalline sulfur-containing polymers, methods and curable compositions for making the same, and orthodontic appliances made from said polymeric materials.

Abstract: The present invention relates to compositions and methods for enhancing the gene silencing activity of oligonucleotide compounds. In particular, the invention relates to inhibiting the expression or activity of suppressor proteins, such as RAB18, ZW10, STX18, SCFD2, NAPG, SAMD4B, or VPS37A, to increase the efficacy of ligand-conjugated oligonucleotide compounds in reducing the expression of target genes in a cell.

Abstract: The present disclosure relates to novel intermediates, preparation process thereof, and a process for producing isofetamid. The present disclosure also relates to the use of novel intermediates for preparing isofetamid. The present disclosure further relates to a process for preparation of some other intermediates of isofetamid using the novel intermediates.

Abstract: A semiconductor device having a plurality of layers deposited on a substrate and extending in at least one lateral aspect defined by a lateral axis thereof comprises at least one EM radiation-absorbing layer deposited on a first layer surface and comprising a discontinuous layer of at least one particle structure comprising a deposited material. The at least one particle structure of the at least one EM radiation-absorbing layer facilitates absorption of EM radiation therein in at least a part of at least one of a visible spectrum and a UV spectrum while substantially allowing transmission of EM radiation therein in at least a part of at least one of an IR and an NIR spectrum.

Abstract: Provided herein are compounds of the Formula (I), (II), and (III): as well as pharmaceutically acceptable salts thereof, wherein the substituents are those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of oncologic diseases.

Abstract: A compound, of formula (I): suitable for treating a cancer wherein the cancer is susceptible to inhibition of Cbl-B.

Abstract: Systems and methods for generating and maintaining differential privacy while providing accurate values can include obtaining a plurality of noise-added values, processing the plurality of noise-added values to determine a predicted value. The plurality of noise-added value may be utilized to determine one or more accuracy values that can be compared to a threshold to determine if more data is to be obtained and processed before providing a predicted value.

Abstract: Embodiments are directed to wearable electronic devices including a band having a flexible layer and a routing layer coupled to the flexible layer. The routing layer including one or more electrical traces. A first enclosure is coupled to the band at a first opening and includes a first upper enclosure segment coupled to a first side of the band and a first lower enclosure segment coupled to a second side of the band. A processing unit is enclosed within the first enclosure and electrically coupled to the routing layer. A second enclosure is coupled to the band at a second opening and includes a second upper enclosure segment coupled to the first side of the band and a second lower enclosure segment coupled to the second side of the band. A battery is enclosed within the second enclosure and electrically coupled to the processing unit via the routing layer.

Abstract: Slip target adjustment based on an accelerator pedal is provided. A system can detect an amount of torque requested for a vehicle. The system can determine a friction level associated with a surface on which the vehicle traverses. The system can select a slip target modifier. The selection can be based on the amount of torque requested for the vehicle and the friction level. The system can adjust a slip target used by a traction control system of the vehicle. The adjustment can be based on the slip target modifier.

Abstract: Disclosed herein is an apparatus comprising: an auxetic unit-cell, each comprising: a first longitudinal beam, a second longitudinal beam fixably attached to the first longitudinal beam at a first hinge region, the second longitudinal beam is orthogonally disposed with respect to the first longitudinal beam; and a third longitudinal beam fixably attached to the first longitudinal beam at a second hinge region, the third longitudinal beam is orthogonally disposed with respect to the first and second longitudinal beams, wherein the first, second and third longitudinal beams all are different lengths, wherein the first and second hinge region, and the first and third longitudinal beam are configured to bend under load applied in a direction non-parallel to the longitudinal axis of the first longitudinal beam.

Abstract: A method and apparatus for multiple flexible circuit cable attachment is described herein. Gold bumps are bonded on interconnection pads of a substrate to create a columnar structure and solder or conductive epoxy is dispensed on the flexible cable circuit. The substrate and flexible cable circuit are aligned and pressed together using force or placement of a weight on either the substrate or flexible cable circuit. Appropriate heat is applied to reflow the solder or cure the epoxy. The solder wets to the substrate pads, assisted by the gold bumps, and have reduced bridging risk due to the columnar structure. A nonconductive underfill epoxy is applied to increase mechanical strength.

Abstract: The present invention relates to devices and methods for coating surfaces including surfaces of medical devices, in particular the coating of microprojections on microprojection arrays. The present invention also relates to print head devices and their manufacture and to methods of using the print head devices for manufacturing articles such as microprojection arrays as well as to coating the surfaces of microprojection arrays. The present invention also relates to high throughput printing devices that utilize the print heads of the present invention.

Abstract: A flexible map with application data identifiers for PLC communications is described. An example method comprises receiving a first user input indicative of a selection of a parameter from a plurality of parameters associated with an adhesive dispensing system (614). The parameter is subject to data exchange between a controller (616) of the adhesive dispensing system (614) and an associated programmable logic controller (610). A second user input is received that is indicative of a memory space location in a memory space of the controller (616). A custom data map is generated that is indicative of an association between the selected parameter and the memory space location.

Abstract: A full depth ophthalmic surgical system includes a femtosecond laser source and an optical coherence tomographer. The system is capable of performing surgical procedures along the entire length of the eye from the cornea to the retina. The optical system of the ophthalmic surgical system is optimized to focus the laser beam and imaging light in the vitreous humor of the eye. In some embodiments, the system includes a video camera with a tunable lens before it to image the entire length of the eye. For procedures performed posterior to the lens, a method for calibrating the full depth ophthalmic surgical system is also provided. The system can be used to perform treatment in the vitreous humor, including treating floaters and liquification of the vitreous humor.

Abstract: A user equipment includes circuitry which selects a random access preamble sequence, and a transmitter which transmits the random access preamble sequence to a base station in a frequency bandwidth of an unlicensed band, and performs at least one of a first operation and a second operation. In the first operation, the circuitry selects a first sequence as the random access preamble sequence, the first sequence having a length longer than a length of a random preamble sequence used for a licensed band, and the transmitter transmits the first sequence in the frequency bandwidth of the unlicensed band. In the second operation, the circuitry selects a second sequence as the random access preamble sequence, the second sequence having a length equal to the length of a random preamble sequence used for the licensed band, and the transmitter transmits the second sequence with repetitions in the frequency bandwidth of the unlicensed band.

Abstract: Described are a system, method, and computer program product for multivariate event prediction using multi-stream recurrent neural networks. The method includes receiving event data from a sample time period and generating feature vectors for each subperiod of each day. The method also includes providing the feature vectors as inputs to a set of first recurrent neural network (RNN) models and generating first outputs for each RNN node. The method further includes merging the first outputs for each same subperiod to form aggregated time-series layers. The method further includes providing the aggregated time-series layers as an input to a second RNN model and generating final outputs for each RNN node of the second RNN model.

Abstract: The present invention relates to bifunctional compounds, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins which are degraded and/or otherwise inhibited by bifunctional compounds according to the present invention. In particular, the present invention is directed to compounds, which contain on one end a VHL ligand which binds to the ubiquitin ligase and on the other end a moiety which binds a target protein such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of that protein. The present invention exhibits a broad range of pharmacological activities associated with compounds according to the present invention, consistent with the degradation/inhibition of targeted polypeptides.

Abstract: The invention relates to a method for dynamically indicating a TDD reconfiguration to the mobile station by encoding the dynamic TDD re-configuration indication into the DCI or CRC calculated for the DCI. In one embodiment, the TDD configuration indication is implicitly encoded as an RNTI into the CRC, when scrambling the CRC for the DCI with a TDD-RNTI. In another embodiment, the TDD configuration indication is part of the DCI payload, while the CRC for the DCI is scrambled with a cell identifier, identifying the target cell for which the dynamic TDD re-configuration is to be applied. In still another embodiment, the TDD configuration indication is part of the DCI payload, where the DCI payload further includes an invalid parameter indicating to the mobile station that the DCI carries the TDD configuration indication.

Abstract: Embodiments for training a recommendation system to provide merchant recommendations comprise receiving, by a processor, raw merchant embeddings and raw user embeddings generated from payment transaction records, wherein the raw merchant embeddings include a plurality of embedded features. A generative adversarial network (GAN) is trained to generate modified merchant embeddings from the raw merchant embeddings, where the modified embeddings remove a location feature. Subsequent to training and responsive to receiving a request for merchant recommendations in the target location for the target user, the GAN and a trained preference model are used to generate a list of merchant rankings based on a new set of modified merchant embeddings, past preferences of a target user, and the target location to recommend merchants in the target location.