Abstract: A computer-implemented method of generating dose information for a region of patient anatomy includes determining a first set of dose values for a first three-dimensional (3D) image of the region, wherein each value in the first set of dose values is associated with a different voxel of the first 3D image, and wherein the first 3D image is associated with a specific application of dose to the region; determining a second set of dose values for a representative 3D image of the region, wherein each value in the second set of dose values is associated with a different voxel of the representative 3D image; determining a set of geometric error models for the representative 3D image of the region, wherein each geometric error model in the set of geometric error models indicates a geometric error between a voxel of the representative 3D image and one or more voxels of a treatment fraction 3D image of the region; and based on the second set of dose values and the set of geometric error models, determining a set of do