Patents by Inventor Michael Wayne Graham
Michael Wayne Graham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20120277285Abstract: The present invention relates generally to a method of modifying gene expression and to synthetic genes for modifying endogenous gene expression in a cell, tissue or organ of a transgenic organism, in particular a transgenic animal or plant. More particularly, the present invention utilizes recombinant DNA technology to post-transcriptionally modify or modulate the expression of a target gene in a cell, tissue organ or whole organism, thereby producing novel phenotypes. Novel synthetic genes and genetic constructs which are capable of repressing delaying or otherwise reducing the expression of an endogenous gene or target gene in an organism when introduced thereto are also provided.Type: ApplicationFiled: April 27, 2012Publication date: November 1, 2012Inventors: Michael Wayne Graham, Robert Norman Rice
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Publication number: 20120135517Abstract: The present invention relates generally to synthetic genes for modifying endogenous gene expression in a cell, tissue or organ of a transgenic organism, in particular a transgenic animal or plant. More particularly, the present invention provides novel synthetic genes and genetic constructs which are capable of repressing delaying or otherwise reducing the expression of an endogenous gene or a target gene in an organism when introduced thereto.Type: ApplicationFiled: November 7, 2011Publication date: May 31, 2012Inventors: Michael Wayne Graham, Robert Norman Rice
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Patent number: 8168774Abstract: The present invention relates generally to a method of modifying gene expression and to synthetic genes for modifying endo gene expression in a cell, tissue or organ of a transgenic organism, in particular a transgenic animal or plant. More particularly, the invention utilizes recombinant DNA technology to post-transcriptionally modify or modulate the expression of a target gene in tissue, organ or whole organism, thereby producing novel phenotypes. Novel synthetic genes and genetic constructs which are cap repressing delaying or otherwise reducing the expression of an endogenous gene or a target gene in an organism when introduced are also provided.Type: GrantFiled: September 2, 2005Date of Patent: May 1, 2012Assignee: Commonwealth Scientific and Industrial Research OrganisationInventors: Michael Wayne Graham, Robert Norman Rice
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Patent number: 8067383Abstract: The present invention relates generally to synthetic genes for modifying endogenous gene expression in a cell, tissue or organ of a transgenic organism, in particular a transgenic animal or plant. More particularly, the present invention provides novel synthetic genes and genetic constructs which are capable of repressing delaying or otherwise reducing the expression of an endogenous gene or a target gene in an organism when introduced thereto.Type: GrantFiled: January 17, 2003Date of Patent: November 29, 2011Assignee: Commonwealth Scientific and Industrial Research OrganisationInventors: Michael Wayne Graham, Robert Norman Rice
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Patent number: 8053419Abstract: The present invention relates generally to synthetic genes for modifying endogenous gene expression in a cell, tissue or organ of a transgenic organism, in particular a transgenic animal or plant. More particularly, the present invention provides novel synthetic genes and genetic constructs which are capable of repressing delaying or otherwise reducing the expression of an endogenous gene or a target gene in an organism when introduced thereto.Type: GrantFiled: April 8, 2004Date of Patent: November 8, 2011Assignee: Commonwealth Scientific and Industrial Research OrganisationInventors: Michael Wayne Graham, Robert Norman Rice
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Patent number: 8048670Abstract: The present invention relates generally to synthetic genes for modifying endogenous gene expression in a cell, tissue or organ of a transgenic organism, in particular a transgenic animal or plant. More particularly, the present invention provides novel synthetic genes and genetic constructs which are capable of repressing delaying or otherwise reducing the expression of an endogenous gene or a target gene in an organism when introduced thereto.Type: GrantFiled: January 15, 2004Date of Patent: November 1, 2011Assignee: Commonwealth Scientific and Industrial Research OrganisationInventors: Michael Wayne Graham, Robert Norman Rice
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Publication number: 20110117608Abstract: The invention is directed towards constructs for RNAi techniques. The invention provides a ribonucleic acid (RNA) for use as interfering RNA in gene silencing techniques to silence a target gene comprising in a 5? to 3? direction at least a first effector sequence, a second effector sequence, a sequence substantially complementary to the second effector sequence and a sequence substantially complementary to the first effector sequence, wherein the complementary sequences are capable of forming double stranded regions with their respective effector sequences and wherein at least one of these sequences is substantially identical to the predicted transcript of a region of the target gene, and a nucleic acid construct encoding such an RNA.Type: ApplicationFiled: October 28, 2010Publication date: May 19, 2011Applicant: BENITEC AUSTRALIA, LTD.Inventors: MICHAEL WAYNE GRAHAM, KENNETH CLIFFORD REED, ROBERT NORMAN RICE, BRUCE THOMAS HARRISON, PETRUS ROELVINK, DAVID SUHY, ALEXANDER KOLYKHALOV
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Patent number: 7855071Abstract: The present invention relates generally to synthetic genes for modifying endogenous gene expression in a cell, tissue or organ of a transgenic organism, in particular a transgenic animal or plant. More particularly, the present invention provides novel synthetic genes and genetic constructs which are capable of repressing delaying or otherwise reducing the expression of an endogenous gene or a target gene in an organism when introduced thereto.Type: GrantFiled: January 15, 2004Date of Patent: December 21, 2010Assignee: Commonwealth Scientific and Industrial Research OrganisationInventors: Michael Wayne Graham, Robert Norman Rice
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Patent number: 7754697Abstract: The present invention relates generally to a method of modifying gene expression and to synthetic genes for modifying endogenous gene expression in a cell, tissue or organ of a transgenic organism, in particular a transgenic animal or plant. More particularly, the present invention utilises recombinant DNA technology to post-transciptionally modify or modulate the expression of a target gene in a cell tissue, organ or whole organism, thereby producing novel phenotypes. Novel synthetic genes and genetic constructs which are capable repressing delaying or otherwise reducing the expression of an endogenous gene or a target gene in an organism when introduced thereto are also provided.Type: GrantFiled: August 22, 2003Date of Patent: July 13, 2010Assignee: Commonwealth Scientific and Industrial Research OrganisationInventors: Michael Wayne Graham, Robert Norman Rice
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Publication number: 20040266005Abstract: The present invention relates generally to synthetic genes for modifying endogenous gene expression in a cell, tissue or organ of a transgenic organism, in particular a transgenic animal or plant. More particularly, the present invention provides novel synthetic genes and genetic constructs which are capable of repressing delaying or otherwise reducing the expression of an endogenous gene or a target gene in an organism when introduced thereto.Type: ApplicationFiled: April 8, 2004Publication date: December 30, 2004Applicant: BENITEC AUSTRALIA LIMITEDInventors: Michael Wayne Graham, Robert Norman Rice
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Publication number: 20040237145Abstract: The present invention relates generally to a method of modifying gene expression and to synthetic genes for modifying endo gene expression in a cell, tissue or organ of a transgenic organism, in particular a transgenic animal or plant. More particularly, the invention utilises recombinant DNA technology to post-transcriptionally modify or modulate the expression of a target gene in tissue, organ or whole organism, thereby producing novel phenotypes. Novel synthetic genes and genetic constructs which are cap repressing delaying or otherwise reducing the expression of an endogenous gene or a target gene in an organism when introduced are also provided.Type: ApplicationFiled: April 8, 2004Publication date: November 25, 2004Inventors: Michael Wayne Graham, Robert Norman Rice
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Publication number: 20040214330Abstract: Methods and means are provided for reducing the phenotypic expression of a nucleic acid of interest in eucaryotic cells, particularly in plant cells, by introducing chimeric genes encoding sense and antisense RNA molecules directed towards the target nucleic acid, which are capable of forming a double stranded RNA region by base-pairing between the regions with sense and antisense nucleotide sequence or by introducing the RNA molecules themselves. Preferably, the RNA molecules comprises simultaneously both sense and antisense nucleotide sequence.Type: ApplicationFiled: January 13, 2004Publication date: October 28, 2004Inventors: Peter Michael Waterhouse, Ming-Bo Wang, Michael Wayne Graham
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Publication number: 20040180439Abstract: The present invention relates generally to synthetic genes for modifying endogenous gene expression in a cell, tissue or organ of a transgenic organism, in particular a transgenic animal or plant. More particularly, the present invention provides novel synthetic genes and genetic constructs which are capable of repressing delaying or otherwise reducing the expression of an endogenous gene or a target gene in an organism when introduced thereto.Type: ApplicationFiled: January 15, 2004Publication date: September 16, 2004Applicant: BENITEC AUSTRALIA LIMITEDInventors: Michael Wayne Graham, Robert Norman Rice
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Publication number: 20040064842Abstract: The present invention relates generally to a method of modifying gene expression and to synthetic genes for modifying endogenous gene expression in a cell, tissue or organ of a transgenic organism, in particular a transgenic animal or plant. More particularly, the present invention utilises recombinant DNA technology to post-transcriptionally modify or modulate the expression of a target gene in a cell tissue, organ or whole organism, thereby producing novel phenotypes. Novel synthetic genes and genetic constructs which are capable repressing delaying or otherwise reducing the expression of an endogenous gene or a target gene in an organism when introduced thereto are also provided.Type: ApplicationFiled: August 22, 2003Publication date: April 1, 2004Inventors: Michael Wayne Graham, Robert Norman Rice
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Publication number: 20030182672Abstract: A method of inducing, promoting or otherwise facilitating a change in the phenotype of an animal cell or group of animal cells including an animal comprising said cells. The modulation of phenotypic expression is conveniently accomplished via genotypic manipulation through such means as reducing translation of transcript to proteinaceous product. The ability to induce, promote or otherwise facilitate the silencing of expressible genetic sequences provides a means for modulating the phenotype in, for example, the medical, veterinary and the animal husbandry industries. Expressible genetic sequences contemplated by the present invention include not only genes normally resident in a particular animal cell (i.e., indigenous genes) but also genes introduced through recombinant means or through infection by pathogenic agents such as viruses.Type: ApplicationFiled: September 16, 2002Publication date: September 25, 2003Inventors: Michael Wayne Graham, Robert Norman Rice, Kenneth Clifford Reed, Kathleen Margaret Murphy
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Publication number: 20030159161Abstract: The present invention relates generally to synthetic genes for modifying endogenous gene expression in a cell, tissue or organ of a transgenic organism, in particular a transgenic animal or plant. More particularly, the present invention provides novel synthetic genes and genetic constructs which are capable of repressing delaying or otherwise reducing the expression of an endogenous gene or a target gene in an organism when introduced thereto.Type: ApplicationFiled: January 17, 2003Publication date: August 21, 2003Inventors: Michael Wayne Graham, Robert Norman Rice
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Publication number: 20030150017Abstract: Methods are provided for the genetic control of pathogen infestation in host organisms such as plants, vertebrate animals and fungi. Such methods utilize the host as a delivery system for the delivery of genetic agents, preferably in the form of RNA molecules, to a pathogen, which agents cause directly or indirectly an impairment in the ability of the pathogen to maintain itself, grow or otherwise infest a host plant, vertebrate animal or fungus. Also provided are DNA constructs and novel nematode nucleotide sequences for use in same, that facilitate pathogen resistance when expressed in a genetically-modified host. Such constructs direct the expression of RNA molecules substantially homologous and/or complementary to an RNA molecule encoded by a nucleotide sequence within the genome of a pathogen and/or of the cells of a host to effect down-regulation of the nucleotide sequence. Particular hosts contemplated are plants, such as pineapple plants, and particular pathogens are nematodes.Type: ApplicationFiled: November 7, 2002Publication date: August 7, 2003Inventors: Jose Ramon Botella Mesa, Michael Wayne Graham, David James Fairbairn
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Patent number: 6573099Abstract: The present invention relates generally to synthetic genes for modifying endogenous gene expression in a cell, tissue or organ of a transgenic organism, in particular a transgenic animal or plant. More particularly, the present invention provides novel synthetic genes and genetic constructs which are capable of repressing delaying or otherwise reducing the expression of an endogenous gene or a target gene in an organism when introduced thereto.Type: GrantFiled: June 19, 1998Date of Patent: June 3, 2003Assignee: Benitec Australia, Ltd.Inventor: Michael Wayne Graham
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Publication number: 20030074684Abstract: The present invention relates generally to synthetic genes for modifying endogenous gene expression in a cell, tissue or organ of a transgenic organism, in particular a transgenic animal or plant. More particularly, the present invention provides novel synthetic genes and genetic constructs which are capable of repressing delaying or otherwise reducing the expression of an endogenous gene or a target gene in an organism when introduced thereto.Type: ApplicationFiled: November 30, 2001Publication date: April 17, 2003Inventors: Michael Wayne Graham, Robert Norman Rice
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Publication number: 20020168707Abstract: The present invention relates generally to synthetic genes for modifying endogenous gene expression in a cell, tissue or organ of a transgenic organism, in particular a transgenic animal or plant. More particularly, the present invention provides novel synthetic genes and genetic constructs which are capable of repressing delaying or otherwise reducing the expression of an endogenous gene or a target gene in an organism when introduced thereto.Type: ApplicationFiled: June 19, 1998Publication date: November 14, 2002Inventor: MICHAEL WAYNE GRAHAM