Abstract: An antibody that specifically binds to IL-1R3, comprising an antibody heavy chain amino acid sequence of SEQ ID NO: 1 and a light chain amino acid sequence of SEQ ID NO: 2. A pharmaceutical composition is provided comprising the said antibody and a pharmaceutically acceptable diluent, carrier or excipient. Also said antibody for use in treating a disease or disorder in a subject in need thereof. The disease or disorder may be an autoimmune or autoinflammatory disease or disorder.

Abstract: Starch-based extruded food products and methods for manufacturing starch-based extruded food products, such as snacks, are disclosed. For example, a starch-based dough may be extruded, cut, and cooked to form a starch-based extruded food product with a rigid extruded body. The cooking process may include baking and/or frying the cut extrusion. The rigid extruded body of the starch-based extruded food product is made up of bodies or segments coupled at joints. The rigid extruded bodies are configured such that bodies of the rigid extruded body may be broken off or separated at the joints to be consumed.

Abstract: A set of data for training a machine learning system can be modified to improve its performance. An item of information can be transmitted. A message can be transmitted that includes an explanation of a determination, by the machine learning system, to transmit the item of information from among a plurality of items of information. A first set of data can have been used to train the machine learning system. A signal can be received that includes an indication of a usefulness of the message, to a user of a user device, in making a decision to perform an action based on a knowledge associated with the item of information. The first set of data can be modified, in response to a receipt of the signal, to produce a second set of data. The machine learning system can be caused to be trained using the second set of data.

Abstract: Methods, systems, apparatuses, devices, and computer program products are described. An intelligent routing system may route a data object to a path in a process flow using a model, such as a machine-learned model. The system may receive a first data object and may route the first data object along a path of the process flow using a random routing procedure, for example, for model training. The routing may involve performing operations based on the path and the features of the first data object. The system may update one or more models based on an outcome of the operations. Following training, the system may insert a model into the process flow at a decision point between paths. The system may receive a second data object and may route the second data object to a path using the model and based on features of the second data object.

Abstract: Methods, systems, apparatuses, devices, and computer program products are described. A system may identify, from an event log including log entries for a tenant of a multi-tenant database system, a pattern of log entries corresponding to main actions and satisfying a frequency threshold. The system may identify log entries associated with the pattern and corresponding to the main actions, detailed actions, or both. The system may retrieve data corresponding to a history field of a data object associated with the pattern and may determine at least a portion of a process flow for the data object according to the pattern and based on the log entries and the historical data. The process flow may include operations to perform using the data object. In some cases, the system may transmit, to a user device, an indication of the portion of the process flow for user review and implementation.

Abstract: A set of data for training a machine learning system can be modified to improve its performance. An item of information can be transmitted. A message can be transmitted that includes an explanation of a determination, by the machine learning system, to transmit the item of information from among a plurality of items of information. A first set of data can have been used to train the machine learning system. A signal can be received that includes an indication of a usefulness of the message, to a user of a user device, in making a decision to perform an action based on a knowledge associated with the item of information. The first set of data can be modified, in response to a receipt of the signal, to produce a second set of data. The machine learning system can be caused to be trained using the second set of data.

Abstract: Apparatus and methods to deliver kV X-rays toward a target lesion within a body including: a treatment anode configured to receive electron beams and output the kV X-rays through a specially-designed collimator; an electron beam source configured to generate and direct the electron beams toward the treatment anode; and at least one magnet configured to steer and scan the electron beams along the treatment anode to prevent overheating of the treatment anode. The components are mounted on a gantry that rotates about the target lesion to distribute the dose delivered over a large volume of healthy tissue while substantially maximizing the dose delivered to the target lesion.

Abstract: A set of data for training a machine learning system can be modified to improve its performance. An item of information can be transmitted. A message can be transmitted that includes an explanation of a determination, by the machine learning system, to transmit the item of information from among a plurality of items of information. A first set of data can have been used to train the machine learning system. A signal can be received that includes an indication of a usefulness of the message, to a user of a user device, in making a decision to perform an action based on a knowledge associated with the item of information. The first set of data can be modified, in response to a receipt of the signal, to produce a second set of data. The machine learning system can be caused to be trained using the second set of data.

Abstract: Apparatus and methods to deliver kV X-rays toward a target lesion within a body including: a treatment anode configured to receive electron beams and output the kV X-rays through a specially-designed collimator; an electron beam source configured to generate and direct the electron beams toward the treatment anode; and at least one magnet configured to steer and scan the electron beams along the treatment anode to prevent overheating of the treatment anode. The components are mounted on a gantry that rotates about the target lesion to distribute the dose delivered over a large volume of healthy tissue while substantially maximizing the dose delivered to the target lesion.

Abstract: A bumper device for a motor vehicle is described. A cross member assembly includes a cross member running transverse to a traveling direction and a side element extending from an end of the cross member. A side member assembly has a first end configured to be fixed to a vehicle structure and a second end fixed to the cross member. A support member extends from the side member assembly towards an end of the side element opposite the cross member. The support member is configured to absorb and transfer an oblique load acting on the side element to the side member assembly, and to defect without substantial resistance to the longitudinal load acting on the cross member in the traveling direction.

Abstract: An optical resonance scanner has a spring-elastic bending element (10) excitable to effect rotational oscillations about a longitudinal axis (A-A) using a stationary magnet (9) and a stationary drive coil (5) that is wound around a pole shoe (20). The pole shoe (20) is magnetically coupled to the magnet (9) and has two mutually opposite free ends (21, 22) between which the bending element (10) is arranged symmetrically so that a magnetic flux can be transferred substantially perpendicularly to the longitudinal axis (A-A). In superimposition of the magnet- and coil-induced magnetic fluxes the magnet (9) and a first half (23) of the pole shoe (20) form a first magnetic circuit (30), and the magnet (9) and a second half (24) of the pole shoe (20) form a second magnetic circuit (31), which run in opposite senses with respect to one another in a plane perpendicularly to the longitudinal axis (A-A) through a magnetizable section (6) of the bending element (10).

Abstract: An optical resonance scanner has a spring-elastic bending element (10) excitable to effect rotational oscillations about a longitudinal axis (A-A) using a stationary magnet (9) and a stationary drive coil (5) that is wound around a pole shoe (20). The pole shoe (20) is magnetically coupled to the magnet (9) and has two mutually opposite free ends (21, 22) between which the bending element (10) is arranged symmetrically so that a magnetic flux can be transferred substantially perpendicularly to the longitudinal axis (A-A). In superimposition of the magnet- and coil-induced magnetic fluxes the magnet (9) and a first half (23) of the pole shoe (20) form a first magnetic circuit (30), and the magnet (9) and a second half (24) of the pole shoe (20) form a second magnetic circuit (31), which run in opposite senses with respect to one another in a plane perpendicularly to the longitudinal axis (A-A) through a magnetizable section (6) of the bending element (10).

Abstract: A frame structure for a motor vehicle is disclosed which includes a side member, a bumper cross member, a first crash box arranged in extension of the side member and a second crash box, which obliquely branches off to the side from the arrangement of side member and first crash box. The bumper cross member protrudes over the first crash box towards the side, and an outer end of the second crash box is fastened to the bumper cross member.

Abstract: A frame structure for a motor vehicle is disclosed which includes a side member, a bumper cross member, a first crash box arranged in extension of the side member and a second crash box, which obliquely branches off to the side from the arrangement of side member and first crash box. The bumper cross member protrudes over the first crash box towards the side, and an outer end of the second crash box is fastened to the bumper cross member.

Abstract: Contrast agents developed specifically for x-ray diagnostics provide dose-enhanced radiotherapy and radiosurgery. The presence of heavy elements, for example, gold or iron, from these contrast agents, even small quantities, leads to a major dose increase in target tissue when combined with in vivo calibration of the amount of contrast agent. The technique can also be used in combination with other techniques, such as focused x-rays, to achieve further enhancement of therapeutic ratio. The technique is enhanced by employing oil-based contrast agents, which will remain in the target much longer than conventional agents. Through optimization of the equipment it is possible to achieve very large ratios of dose in target to dose in healthy tissue.

Abstract: Radiation has been used for many years to treat cancer patients. In the case of ionizing electromagnetic radiation, the incidental, extra dose to tissues surrounding the tumor is significant. The aim of this invention is to provide compounds and methods to enhance the absorbed radiation dose ratio, or other therapeutic compounds, in tumors verses normal tissue. The system concentrates contrast agents with high atomic number elements preferentially at the site of the tumor prior to administering radiotherapy, or preferentially concentrates other therapeutic compounds in the abnormal region. The agents are concentrated in a pathologic lesion following systemic or direct administration. Interaction of the ionizing radiation with the coupled compounds of this invention results in a significantly higher radiation dose to the tumor compared to surrounding tissues. The result is greater therapeutic efficacy with fewer side effects following treatment with low-energy radiation, or other agents.

Abstract: A global framework multi-layer computer based architecture is provided. The global framework may include a single set of libraries that contains common source code applicable to substantially all business processing systems using the global framework. The global framework may include individual source code libraries that contain modifications specific to a business processing system to meet the local needs of that business processing system. The business processing systems may execute the custom and base libraries through concatenation of the libraries.

Abstract: Embodiments may include determination of a treatment plan associated with a patient, the treatment plan including a first treatment mode in which a treatment agent is present within a portion of the patient and a second treatment mode in which the portion of the patient is irradiated, determination, independent from the second treatment mode, of whether the first treatment mode meets a first safety threshold, determination, independent from the first treatment mode, of whether the second treatment mode meets a second safety threshold, and determination of whether a combination of the first treatment mode and the second treatment mode meets a third safety threshold.

Abstract: A system may include a radiation treatment agent to treat tissue in response to received X-ray radiation and an identifier associated with the radiation treatment agent. The identifier may be usable to identify a radiation treatment plan. In some embodiments, a radiation treatment plan associated with a patient is generated, the radiation treatment plan is associated with an identifier and a patient identifier identifying the patient, a radiation treatment agent is prepared for delivery to the patient according to the radiation treatment plan, and the radiation treatment agent is associated with the identifier.

Abstract: Contrast agents developed specifically for x-ray diagnostics provide dose-enhanced radiotherapy and radiosurgery. The presence of heavy elements, for example, gold or iron, from these contrast agents, even small quantities, leads to a major dose increase in target tissue when combined with in vivo calibration of the amount of contrast agent. The technique can also be used in combination with other techniques, such as focused x-rays, to achieve further enhancement of therapeutic ratio. The technique is enhanced by employing oil-based contrast agents, which will remain in the target much longer than conventional agents. Through optimization of the equipment it is possible to achieve very large ratios of dose in target to dose in healthy tissue.