Abstract: The invention is intended for a treatment of severe infections using an injectable drug-delivery system comprising nanoparticles of a biodegradable polymer with incorporated antibacterial drug.

Abstract: Topical composition for enhanced local and systemic delivery of poorly soluble biologically active compounds, comprises of non-volatile solvent or mixture of solvents to dissolve active component, and moisture absorbent or mixture of sorbents to prevent precipitation or crystallization of insoluble material after application

Abstract: The present invention relates to oxacyclopentene-2 derivatives as compounds possessing antiinflammatory, neuroprotective, immunomodulatory and cardiovascular activities in mammals.

Abstract: The invention relates to a nanoparticulate colloidal delivery vehicle comprising a biodegradable polymer in combination with a hydrophobic lipid component. Variation of the lipid and polymer types and variation in the ratio between the polymer and lipid components allows regulation of drug loading and release rate.

Abstract: There is provided an ophthalmic pharmaceutical preparation comprising menthyl ester of indomethacin as an active ingredient. Also provided are different possible formulations of the ophthalmic preparation, and different methods of treating ophthalmic irritation using the ophthalmic preparation.

Abstract: The present invention provides a self-emulsifiable composition and a stable topical emulsion comprising same, which comprises salicylate, oils and surfactants and which does not require organic solvents. The invention also provides methods for manufacturing the compositions. The topical compositions of the invention can be used to enhance delivery of salicylates and are useful in the prevention and treatment of pain and inflammation.

Abstract: The present invention provides a self-emulsifiable composition and a stable topical emulsion comprising same, which comprises salicylate esters, oils and surfactants and which does not require organic solvents. The invention also provides methods for manufacturing the compositions. The topical compositions of the invention can be used to enhance delivery of salicylate esters and are useful in the prevention and treatment of pain and inflammation.

Abstract: The stabilization of benzoyl peroxide for extended periods of time is disclosed. The stabilized solution contains from between 0.5% and 20% organic peroxide and a stabilizer for preventing degradation of said peroxide in the solution.

Abstract: A vehicle for topical delivery which contains a liquid eutectic mixture of hydrophobic compounds.

Abstract: A vehicle for topical delivery which contains a liquid eutectic mixture of hydrophobic compounds.

Abstract: The invention provides a drug carrier that includes a solid lipid nanoparticle (SLN), wherein the SLN includes tocopherol or a derivative thereof. The invention also provides a pharmaceutical composition that includes a SLN and a biologically active compound, wherein the SLN comprises tocopherol or a derivative thereof. The present invention further provides a colloidal drug delivery system that includes solid lipid nanoparticles (SLNs), wherein the SLNs comprise tocopherol or a derivative thereof. Also provided are methods for preparing the drug carrier, pharmaceutical composition, and colloidal drug delivery system of the invention.

Abstract: A vehicle for topical delivery which contains a liquid eutectic mixture of hydrophobic compounds.

Abstract: The stabilization of benzoyl peroxide for extended periods of time is disclosed. The stabilized solution contains from between 0.5% and 20% organic peroxide and a stabilizer for preventing degradation of said peroxide in the solution.

Abstract: A topical composition for treatment of skin disorders such as acne is disclosed. The composition includes benzoyl peroxide in an amount from between 0.5 and 20% by weight. There is also provided a water miscible solvent for solubilizing the benzoyl peroxide in an amount from between 10% and 95% by weight and finally, a water miscible or water dispersible surfactant is present in an amount from between 0.5 and 95% by weight.

Abstract: A vehicle for topical application which contains a liquid eutectic mixture of hydrophobic compounds to improve solubility of pharmaceutically active component and enhance topical and transdermal delivery.

Abstract: A vehicle for topical delivery which contains a liquid eutectic mixture of hydrophobic compounds.