Abstract: The present disclosure provides for compounds of Formula (I) wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).

Abstract: A workpiece drive for rotating a circular workpiece in a descaling device has a carrier and at least three support roller modules. Each of the support roller modules has a bearing and a support roller for the circular workpiece. The support roller has a longitudinal axis, a lateral surface and a radius between the longitudinal axis and the lateral surface, and the radius decreases in a longitudinal direction along the longitudinal axis. The bearing supports the support roller rotatably around the longitudinal axis. Each of the support roller modules has a drive and the drive is designed to rotate the support roller around the longitudinal axis. The bearings are arranged on the carrier in such a way that the longitudinal axes have a point of intersection and lie in a plane perpendicular to the earth gravity field vector and such that the longitudinal directions are directed towards the point of intersection.

Abstract: The present disclosure provides for compounds of Formula (I) wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).

Abstract: A method for separating a workpiece includes removing material of the workpiece along a separation line by using a laser beam comprising ultrashort laser pulses of an ultrashort pulse laser. The material of the workpiece is transparent to a wavelength of the laser beam, and has a refractive index between 2.0 and 3.5. The method further includes separating the workpiece along a notch formed by the removal of the material.

Abstract: The present disclosure provides for compounds of Formula (I) wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents for the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).

Abstract: Disclosed herein are compounds that inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases using the compounds.

Abstract: The present disclosure provides for compounds of Formula (I) wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents for the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).

Abstract: Disclosed herein are compounds that inhibit the activity of anti-apoptotic Bc1-2 proteins, compositions containing the compounds and methods of treating diseases using the compounds.

Abstract: The present disclosure provides for compounds of Formula (I) wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents for the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).

Abstract: The present disclosure provides for compounds of Formula (I) wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).

Abstract: According to an example, data acceleration may include receiving indications of levels of capabilities respectively needed for data movement, data processing, and data interactivity, and/or operational parameters associated with the data movement, the data processing, and the data interactivity. Data acceleration may further include determining, based on an analysis of the received indications and/or the operational parameters, specifications for the data movement to include streaming and/or batch, the data processing to include a big data platform, complex event processing, and/or an appliance, and the data interactivity to include an in-memory database (IMDB) and/or a distributed cache.

Abstract: Disclosed herein are compounds that inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases using the compounds.

Abstract: A cleaning apparatus for cleaning articles is proposed. The cleaning apparatus comprises a cleaning chamber for receiving the articles. The cleaning apparatus has at least one application device for applying at least one cleaning fluid to the articles in the cleaning chamber. The cleaning apparatus has at least one door for opening the cleaning chamber and for loading and unloading the cleaning chamber with articles. The door has at least one at least partially transparent handle. The cleaning apparatus has at least one illuminating device. The illuminating device is designed to illuminate the handle at least partially and illuminate the cleaning chamber and/or an inner side of the door in an opened state of the door.

Abstract: Disclosed herein are compounds that inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases using the compounds. One embodiment of such compounds is 4-(4-{[2-(4-chloro-2-fluorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide.

Abstract: Disclosed herein are compounds that inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases using the compounds.

Abstract: According to an example, data acceleration may include receiving indications of levels of capabilities respectively needed for data movement, data processing, and data interactivity, and/or operational parameters associated with the data movement, the data processing, and the data interactivity. Data acceleration may further include determining, based on an analysis of the received indications and/or the operational parameters, specifications for the data movement to include streaming and/or batch, the data processing to include a big data platform, complex event processing, and/or an appliance, and the data interactivity to include an in-memory database (IMDB) and/or a distributed cache.

Abstract: A cleaning apparatus for cleaning articles is proposed. The cleaning apparatus comprises a cleaning chamber for receiving the articles. The cleaning apparatus has at least one application device for applying at least one cleaning fluid to the articles in the cleaning chamber. The cleaning apparatus has at least one door for opening the cleaning chamber and for loading and unloading the cleaning chamber with articles. The door has at least one at least partially transparent handle. The cleaning apparatus has at least one illuminating device. The illuminating device is designed to illuminate the handle at least partially and illuminate the cleaning chamber and/or an inner side of the door in an opened state of the door.

Abstract: Disclosed herein are compounds that inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases using the compounds.

Abstract: Disclosed herein are compounds that inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases using the compounds.

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression one or more than one of an anti-apoptotic protein family member.