Abstract: A method for operating a supercharged internal combustion engine. Before a cold start of the engine, an electric drive device of an electrically assisted exhaust-gas turbocharger of the engine is activated such that fresh air is compressed by a compressor of the turbocharger and, in the process, is heated and is conveyed via an open overrun air recirculation valve arranged downstream of the compressor, through a short circuit back to a suction side of the compressor of the turbocharger. A proportion of the air that is heated by way of the short-circuit operation of the compressor is, downstream of the compressor and upstream of a closed throttle flap of the engine, conducted via a secondary air system into an exhaust manifold and from there via a wastegate of the turbocharger into the catalytic converters of an exhaust-gas aftertreatment device of the engine.

Abstract: Described herein are methods and compositions for treating and/or preventing a microbial infection. Aspects of the invention relate to administering to a subject an agent that inhibits CGRP release and CGRP receptors. In some embodiments of any of the aspects, a subject has been diagnosed with having, or is at risk of having, a microbial infection.

Abstract: Described herein are methods and compositions for treating and/or preventing a microbial infection. Aspects of the invention relate to administering to a subject an agent that inhibits CGRP release and CGRP receptors. In some embodiments of any of the aspects, a subject has been diagnosed with having, or is at risk of having, a microbial infection.

Abstract: An exhaust system (1) of an internal combustion engine, prior to a first heating-up of the exhaust system (1), has a particle filter (2) and an exhaust line (3) upstream of the particle filter (2). The exhaust system (1) has a carrier element (11) with ash-forming components or ash applied thereto. The carrier element (11) may be on a side of the particle filter (2) facing toward the exhaust line (3). Alternatively, the exhaust system (1) may have a catalytic converter (4) upstream of the particle filter (2), the carrier element (11) that with the ash-forming components or the ash may be applied to the catalytic converter (4).

Abstract: Described herein are methods and compositions for treating and/or preventing a microbial infection. Aspects of the invention relate to administering to a subject an agent that inhibits CGRP release and CGRP receptors. In some embodiments of any of the aspects, a subject has been diagnosed with having, or is at risk of having, a microbial infection.

Abstract: A method is provided for producing at least one ash-forming element (1) for a particulate filter of an exhaust gas system of a gasoline engine or diesel engine. The method includes providing of a strip-shaped center layer (3), and making receiving holes (6) in the center layer (3). The method continues by providing of a strip-shaped bottom layer (4), and permanently connecting of the bottom layer (4) to the center layer (3). The method proceeds by filling the receiving holes (6) of the center layer (3) with ash-forming components (2), providing a strip-shaped top layer (5), and permanently connecting the top layer (5) to the center layer (3). The method then includes punching out of at least one ash-forming means (1) from the wafer, and making throughflow openings (7) in regions where there are no ash-forming components (2).

Abstract: An exhaust gas system (1) has a main flow path (2) with an exhaust gas aftertreatment device (4), and a bypass flow path (3) that has a fan (5) and a heating apparatus (6). The bypass flow path (3) has opposite ends connected to the main flow path (2) in regions upstream and downstream of the exhaust gas aftertreatment device (4). A shut-off (7) is arranged in the main flow path (2) upstream of the bypass flow path, and a further shut-off (8) is arranged in the main flow path downstream of the bypass flow path.

Abstract: A method is provided for producing at least one ash-forming element (1) for a particulate filter of an exhaust gas system of a gasoline engine or diesel engine. The method includes providing of a strip-shaped center layer (3), and making receiving holes (6) in the center layer (3). The method continues by providing of a strip-shaped bottom layer (4), and permanently connecting of the bottom layer (4) to the center layer (3). The method proceeds by filling the receiving holes (6) of the center layer (3) with ash-forming components (2), providing a strip-shaped top layer (5), and permanently connecting the top layer (5) to the center layer (3). The method then includes punching out of at least one ash-forming means (1) from the wafer, and making throughflow openings (7) in regions where there are no ash-forming components (2).

Abstract: An exhaust system (1) of an internal combustion engine, prior to a first heating-up of the exhaust system (1), has a particle filter (2) and an exhaust line (3) upstream of the particle filter (2). The exhaust system (1) has a carrier element (11) with ash-forming components or ash applied thereto. The carrier element (11) may be on a side of the particle filter (2) facing toward the exhaust line (3). Alternatively, the exhaust system (1) may have a catalytic converter (4) upstream of the particle filter (2), the carrier element (11) that with the ash-forming components or the ash may be applied to the catalytic converter (4).

Abstract: An exhaust gas system (1) has a main flow path (2) with an exhaust gas aftertreatment device (4), and a bypass flow path (3) that has a fan (5) and a heating apparatus (6). The bypass flow path (3) has opposite ends connected to the main flow path (2) in regions upstream and downstream of the exhaust gas aftertreatment device (4). A shut-off (7) is arranged in the main flow path (2) upstream of the bypass flow path, and a further shut-off (8) is arranged in the main flow path downstream of the bypass flow path.

Abstract: A method for producing a gasoline engine exhaust gas system having a particulate filter includes using at least one spacer for positioning at least two components provided for the passage of exhaust gas from the engine. The spacer includes ash-forming constituents. The method then includes permanently connecting the components, and burning the spacer element during a first heating up of the exhaust gas system, thereby releasing the ash-forming constituents and depositing the ash-forming constituents on the particulate filter. An exhaust gas system of a gasoline engine also is provided in a state before a first heating up of the exhaust gas system. The exhaust gas system includes a burnable spacer element between two exhaust gas system components that are provided for the passage of exhaust gas. The burnable spacer elements include ash-forming constituents.

Abstract: A method for producing a gasoline engine exhaust gas system having a particulate filter includes using at least one spacer for positioning at least two components provided for the passage of exhaust gas from the engine. The spacer includes ash-forming constituents. The method then includes permanently connecting the components, and burning the spacer element during a first heating up of the exhaust gas system, thereby releasing the ash-forming constituents and depositing the ash-forming constituents on the particulate filter. An exhaust gas system of a gasoline engine also is provided in a state before a first heating up of the exhaust gas system. The exhaust gas system includes a burnable spacer element between two exhaust gas system components that are provided for the passage of exhaust gas. The burnable spacer elements include ash-forming constituents.

Abstract: A method for producing a gasoline engine exhaust gas system having a particulate filter includes using at least one spacer for positioning at least two components provided for the passage of exhaust gas from the engine. The spacer includes ash-forming constituents. The method then includes permanently connecting the components, and burning the spacer element during a first heating up of the exhaust gas system, thereby releasing the ash-forming constituents and depositing the ash-forming constituents on the particulate filter. An exhaust gas system of a gasoline engine also is provided in a state before a first heating up of the exhaust gas system. The exhaust gas system includes a burnable spacer element between two exhaust gas system components that are provided for the passage of exhaust gas. The burnable spacer elements include ash-forming constituents.

Abstract: A device for cooling charge air, specifically for cooling charge air which is compressed in a compressor of at least one exhaust-gas turbocharger and which is to be supplied to an internal combustion engine, wherein at least two charge-air coolers are arranged in a common housing, specifically in such a way that charge air to be cooled can be supplied separately to the charge-air coolers arranged in the common housing via in each case one separate incoming-air chamber provided by the common housing, and that cooled charge air can be discharged jointly from the charge-air coolers arranged in the common housing via a common outgoing-air chamber provided by the common housing.

Abstract: An exhaust system for an internal combustion engine, having a first exhaust tract assigned to a first group of cylinders of the internal combustion engine, and having a second exhaust tract assigned to a second group of cylinders of the internal combustion engine, each exhaust tract comprising an exhaust gas purification device, a first silencer arranged on the outlet side of the respective exhaust gas purification device, and a second silencer arranged on the outlet side of the respective first silencer. Each exhaust tract includes a bypass line, it being possible for exhaust gas to be diverted via each bypass line, starting from the respective first silencer, bypassing the second silencers, and the bypass lines and hence the first silencers of both exhaust tracts being connected to one another by a mixing line.

Abstract: The present invention is based on the surprising discovery that agonists of TLR8 are uniquely efficacious in enhancing (e.g. inducing) the immune response of newborns. Thus, agonists of TLR8 serve as both vaccine adjuvants and as adjunctive therapies for acute infection in newborns, preferably the agonist is a TLR8-selective agonist. The immune response induced, or enhanced, in the neonatal host can be, for example, a cytokine immune response and/or a humoral immune response (e.g., antigen-specific).

Abstract: A device for cooling charge air, specifically for cooling charge air which is compressed in a compressor of at least one exhaust-gas turbocharger and which is to be supplied to an internal combustion engine, wherein at least two charge-air coolers are arranged in a common housing, specifically in such a way that charge air to be cooled can be supplied separately to the charge-air coolers arranged in the common housing via in each case one separate incoming-air chamber provided by the common housing, and that cooled charge air can be discharged jointly from the charge-air coolers arranged in the common housing via a common outgoing-air chamber provided by the common housing.

Abstract: Disclosed herein is an internal combustion engine having horizontally arranged cylinder banks which are arranged on remote sides of a crankcase, which accommodates a crankshaft, of the internal combustion engine, and also having at least one exhaust-gas turbocharger with exhaust-gas turbocharger shaft. In an internal combustion engine of this type, it is provided that the at least one exhaust-gas turbocharger is arranged above the crankcase, and the axis of the exhaust-gas turbocharger shaft is arranged so as to be aligned horizontally and at 90° to the crankshaft axis. An internal combustion engine of this type has particularly good thermodynamic characteristics while being of compact design.

Abstract: An exhaust system for an internal combustion engine, having a first exhaust tract assigned to a first group of cylinders of the internal combustion engine, and having a second exhaust tract assigned to a second group of cylinders of the internal combustion engine, each exhaust tract comprising an exhaust gas purification device, a first silencer arranged on the outlet side of the respective exhaust gas purification device, and a second silencer arranged on the outlet side of the respective first silencer. Each exhaust tract includes a bypass line, it being possible for exhaust gas to be diverted via each bypass line, starting from the respective first silencer, bypassing the second silencers, and the bypass lines and hence the first silencers of both exhaust tracts being connected to one another by a mixing line.

Abstract: A double-flow exhaust system for an internal-combustion engine, having exhaust-gas-carrying pipes and at least one muffler and catalyst housing. A separate end muffler is provided for each exhaust line, on which the end mufflers are both fluidically connected by at least one preferably mountable connection pipe.