Patents by Inventor Michael White
Michael White has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240091256Abstract: Disclosed are methods of making a genetically modified immune cell for modifying a tumor microenvironment (TME) and methods of modifying a tumor microenvironment (TME). In some embodiments, the method can include delivering a first vector to an immune cell, wherein the first vector comprises a nucleic acid encoding a protein that induces T-cell proliferation, promotes persistence and activation of endogenous or adoptively transferred NK or T cells and/or induces production of an interleukin, an interferon, a PD-1 checkpoint binding protein, HMGB1, MyD88, a cytokine or a chemokine. Methods of modulating the suppression of the immune response in a tumor microenvironment, minimizing the proliferation of tumor and suppressive cells, and increasing the efficiency of an anti-cancer therapy, anti-infection therapy, antibacterial therapy, anti-viral therapy, or anti-tumoral therapy are also provided.Type: ApplicationFiled: October 17, 2023Publication date: March 21, 2024Inventors: Courtney Crane, Michael C. Jensen, Kara White Moyes, Nicole Lieberman
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Publication number: 20240082397Abstract: The present invention is directed to anti-PVRIG antibodies and stable liquid pharmaceutical formulations thereof. The present invention is directed to monotherapy and combination treatments with anti-PVRIG antibodies and anti-PD-1 antibodies, in particular nivolumab, using stable liquid pharmaceutical formulations thereof.Type: ApplicationFiled: January 28, 2022Publication date: March 14, 2024Inventors: Mark WHITE, Inbal BARBIRO, Ilan VAKNIN, Assaf WOOL, Zurit LEVINE, Henry Adeboye ADEWOYE, MD, Michael BUCKLEY, Jun LU, John HUNTER, Anat COHEN-DAYAG, Gad S. COJOCARU, Eran OPHIR, Zoya ALTEBER
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Publication number: 20240074976Abstract: Cryogranulation systems with improved dispenser assemblies are provided for use in manufacturing frozen pellets of pharmaceutical substances in a fluid medium. Methods of cryogranulating the pharmaceutical substance in the fluid medium are also provided. In particular embodiments, the dispenser assembly is used with suspensions or slurries of pharmaceutical compositions including biodegradable substances, such as proteins, peptides, and nucleic acids. In certain embodiments, the pharmaceutical substance can be adsorbed to any pharmaceutically acceptable carrier particles suitable for making pharmaceutical powders. In one embodiment, the pharmaceutical carrier can be, for example, diketopiperazine-based microparticles. The dispenser assembly improves the physical characteristics of the cryopellets formed and minimizes product loss during processing.Type: ApplicationFiled: November 2, 2023Publication date: March 7, 2024Applicant: MannKind CorporationInventors: Edwin Amoro, Karel Vanackere, Michael A. White
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Publication number: 20240068558Abstract: Magnetically-assisted mechanical gear systems and other power transmission systems, and related methods of operation and assembly, are disclosed herein. In an example embodiment, such a system includes a driving gear, a driven gear, and a first magnetomotive force (MMF) source that generates a magnetic flux. A first portion of the flux is communicated between at least one driving gear teeth and at least one driven gear teeth so that one or more magnetic forces are exerted between the gears. When the first rotational movement of the driving gear alternates from being in the first rotational direction to being in a third rotational direction opposite the first rotational direction, then the driven gear is driven by the one or more magnetic forces so that the second rotational movement also alternates, and a first amount of backlash movement between the driving and driven gears is avoided or reduced.Type: ApplicationFiled: August 31, 2022Publication date: February 29, 2024Inventors: Adam Michael White, Joseph Michael Stock, Joshua Max Jones, Waleed Said, Nicholas Shaun Palmer, David George Kloos
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Patent number: 11915571Abstract: A dynamic spatial monitoring platform is disclosed that provides improved management and compliance with guest-spacing requirements. The spatial monitoring platform may include a plurality of tracking modules that are configured to capture environmental data of an environment with guests. The environmental data is processed to identify spacing or distancing between guests and in response, cause one or more images to be displayed or projected by the tracking modules to provide visual feedback to one or more guests relating to their spatial relationship with other guests.Type: GrantFiled: June 1, 2021Date of Patent: February 27, 2024Inventors: Joshua Updike, Joseph White, Michael King, Natalie Concors
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Patent number: 11889791Abstract: A device for leveling a surface; the device includes a shaft, a handle-means and a head-assembly. The shaft is selectively retractable, and the head-assembly is foldable to enable compact storage. The device is for personal use by a user in leveling a surface; for example, a sand bunker/sand trap on a golf course. In some versions, the device further includes an attachment-means for attaching the device to a bag.Type: GrantFiled: March 22, 2021Date of Patent: February 6, 2024Assignee: Curran Golf Inc.Inventors: Ryan Curran, Michael White, Richard Gregory Elmer
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Patent number: 11883064Abstract: An access device for accessing an intervertebral disc having an outer shield comprising an access shield with a larger diameter (˜16-30 mm) that reaches from the skin down to the facet line, with an inner shield having a second smaller diameter (˜5-12 mm) extending past the access shield and reaches down to the disc level. This combines the benefits of the direct visual microsurgical/mini open approaches and the percutaneous, “ultra-MIS” techniques.Type: GrantFiled: March 26, 2021Date of Patent: January 30, 2024Assignee: Medos International SarlInventors: Daniel Thommen, Joern Richter, Michael Wang, Richard Assaker, Richard Fessler, Christoph Mehren, Seang Beng Tan, William Taylor, Eric Buehlmann, Michael White
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Publication number: 20240023988Abstract: Surgical access port stabilization systems and methods are described herein. Such systems and methods can be employed to provide ipsilateral stabilization of a surgical access port, e.g., during spinal surgeries. In one embodiment, a surgical system can include an access port configured for percutaneous insertion into a patient to define a channel to a surgical site and an anchor configured for insertion into the patient's bone. Further, the access port can be coupled to the anchor such that a longitudinal axis of the access port and a longitudinal axis of the anchor are non-coaxial. With such a system, a surgeon or other user can access a surgical site through the access port without the need for external or other stabilization of the access port, but can instead position the access port relative to an anchor already placed in the patient's body.Type: ApplicationFiled: September 30, 2023Publication date: January 25, 2024Inventors: Michael White, Stephane Gully, Jan Klett, Peter Senn, Joern Richter
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Publication number: 20240023989Abstract: Adjustable-length surgical access devices are disclosed herein, which can advantageously allow an overall length of the access device to be quickly and easily changed by the user. The access devices herein can reduce or eliminate the need to maintain an inventory of many different length access devices. In some embodiments, the length of the access device can be adjusted while the access device is inserted into the patient. This can reduce or eliminate the need to swap in and out several different access devices before arriving at an optimal length access device. This can also reduce or eliminate the need to change the access device that is inserted into a patient as the depth at which a surgical step is performed changes over the course of a procedure. Rather, the length of the access device can be adjusted in situ and on-the-fly as needed or desired to accommodate different surgical depths.Type: ApplicationFiled: September 30, 2023Publication date: January 25, 2024Inventors: Michael White, Joern Richter, Jan Klett, Stephane Gully, Veronique Zollmann, Richard Kocharian
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Patent number: 11865391Abstract: A forest fire retardant composition contains a retardant compound that includes a phosphate salt. The phosphate salt may include diammonium phosphate, diammonium orthophosphate, monoammonium phosphate, monoammonium orthophosphate, monosodium phosphate, disodium phosphate, disodium phosphate hydrate, sodium ammonium phosphate, sodium ammonium phosphate hydrate, sodium tripolyphosphate, trisodium phosphate, or dipotassium phosphate, and combinations thereof. The forest fire retardant composition may include an ammonium source. The composition may be in the form of a dry concentrate, a liquid concentrate, or a final diluted product. The final diluted product is effective in suppressing, retarding, and controlling forest fires while exhibiting corrosion resistance and low toxicity.Type: GrantFiled: December 1, 2022Date of Patent: January 9, 2024Assignee: FRS Group, LLCInventors: Dennis Hulbert, Robert J. Burnham, Michael S. Schnarr, Gerald Geissler, David W. Wilkening, Joseph McLellan, Michael White
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Patent number: 11865392Abstract: A forest fire retardant composition contains a retardant compound that includes a phosphate salt. The phosphate salt may include diammonium phosphate, diammonium orthophosphate, monoammonium phosphate, monoammonium orthophosphate, monosodium phosphate, disodium phosphate, disodium phosphate hydrate, sodium ammonium phosphate, sodium ammonium phosphate hydrate, sodium tripolyphosphate, trisodium phosphate, or dipotassium phosphate, and combinations thereof. The forest fire retardant composition may include an ammonium source. The composition may be in the form of a dry concentrate, a liquid concentrate, or a final diluted product. The final diluted product is effective in suppressing, retarding, and controlling forest fires while exhibiting corrosion resistance and low toxicity.Type: GrantFiled: April 12, 2023Date of Patent: January 9, 2024Assignee: FRS Group, LLCInventors: Dennis Hulbert, Robert J. Burnham, Michael S. Schnarr, Gerald Geissler, David W. Wilkening, Joseph McLellan, Michael White
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Patent number: 11858350Abstract: Systems, methods and computer readable storage media provide flexible vehicle status notifications via an instrument cluster displayed on an in-vehicle screen. In some examples, when a non-displayed gauge goes into an out-of-parameter or warning range, the gauge may be dynamically shown in the out-of-parameter or warning state in a container position assigned to the gauge in another display or in a dynamic container position in the instrument cluster. In some examples, a popup notification may be provided to inform the driver of a condition. When there are multiple notifications, they may be grouped into definable severity classifications and prioritized so that a notification determined to be a most important message at the time is presented to the driver in a notification zone central to a driver's field of vision on the instrument cluster that allows for reusing screen space for providing warning and information from a range of data sources.Type: GrantFiled: October 9, 2020Date of Patent: January 2, 2024Assignee: PACCAR Inc.Inventors: Steven Karl Jahns, Ryan Anthony Reed, Jonathan Scott Duncan, Jon Forrest Acton, Jacob Michael White, Raeef Hesham Wahib Barsoum, Brett Grant Kellerstedt, Ian Ramsay Hunt, Hervé Jen Raymond Cecchi, Anna-Magdalena Schatz, Christina Nenke, Marc George Wilczak, Nicole Johnson
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Publication number: 20230407425Abstract: A method of treating a valve body is disclosed herein. The method includes using a medium carbon steel, and treating the valve body to a carburizing heating step, an intermediate annealing step, a hardening step, and a tempering step. These steps provide a durable valve seat surface for the valve body such that the valve seat can withstand the conditions that involve high friction or otherwise intense operating conditions, such as oil and gas applications.Type: ApplicationFiled: May 31, 2022Publication date: December 21, 2023Applicant: SCHAEFFLER TECHNOLOGIES AG & CO. KGInventors: Markus Dinkel, Yegor Rudnik, Werner Trojahn, Michael Conlin, Michael White
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Patent number: 11845917Abstract: A cleaning composition is disclosed for cleaning residue and/or contaminants from microelectronic devices having same thereon. The composition comprises at least one complexing agent, at least one cleaning additive, at least one pH adjusting agent, water, and at least one oxylamine compound. Advantageously, the compositions show effective cleaning of cobalt-containing substrates and improved cobalt compatibility.Type: GrantFiled: November 25, 2019Date of Patent: December 19, 2023Assignee: ENTEGRIS, INC.Inventors: Daniela White, Donald Frye, Elizabeth Thomas, Jun Liu, Michael White
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Publication number: 20230398393Abstract: A forest fire retardant composition contains a retardant compound that includes a potassium salt. The potassium salt may include a potassium salt of an organic acid, a potassium salt of an inorganic acid, or mixtures thereof. The organic acid may include formic acid, acetic acid, propanoic acid, butanoic acid, lactic acid, oxalic acid, malic acid, gluconic acid, tartaric acid, uric acid, malic acid, or citric acid. The inorganic acid may include sulfuric acid, phosphoric acid, carbonic acid, or hydrochloric acid. The composition may be in the form of a dry concentrate, a liquid concentrate, or a final diluted product. The final diluted product is effective in suppressing, retarding, and controlling forest fires while exhibiting corrosion resistance and low toxicity.Type: ApplicationFiled: August 16, 2023Publication date: December 14, 2023Applicant: FRS Group, LLCInventors: Dennis Hulbert, Robert J. Burnham, Michael S. Schnarr, Gerald Geissler, David W. Wilkening, Joseph McLellan, Michael White, Gerald S. Frankel
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Patent number: 11839688Abstract: Cryogranulation systems with improved dispenser assemblies are provided for use in manufacturing frozen pellets of pharmaceutical substances in a fluid medium. Methods of cryogranulating the pharmaceutical substance in the fluid medium are also provided. In particular embodiments, the dispenser assembly is used with suspensions or slurries of pharmaceutical compositions including biodegradable substances, such as proteins, peptides, and nucleic acids. In certain embodiments, the pharmaceutical substance can be adsorbed to any pharmaceutically acceptable carrier particles suitable for making pharmaceutical powders. In one embodiment, the pharmaceutical carrier can be, for example, diketopiperazine-based microparticles. The dispenser assembly improves the physical characteristics of the cryopellets formed and minimizes product loss during processing.Type: GrantFiled: June 30, 2021Date of Patent: December 12, 2023Assignee: MannKind CorporationInventors: Edwin Amoro, Karel Vanackere, Michael A. White
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Patent number: 11835520Abstract: A system, method, apparatus and diagnostic test for Plasmodium vivax, to determine a likelihood of a specific timing of infection by P. vivax in a subject, and hence identify individuals with a high probability of being infected with otherwise undetectable liver-stage hypnozoites. The system, method, apparatus and diagnostic test relate to the identification of hypnozoites (“dormant” liver-stages), or at least of the likelihood of the subject being so infected. Optionally and preferably, the specific timing relates to recent infections, for example within the last 9 months.Type: GrantFiled: December 21, 2017Date of Patent: December 5, 2023Assignee: The Walter and Eliza Hall Institute of Medical ResearchInventors: Ivo Mueller, Takafumi Tsuboi, Michael White, Rhea Longley
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Patent number: 11828359Abstract: A system, method, and computer readable storage device are provided for providing a dynamic tachometer. Based on various signal inputs from a plurality of data sources, a tachometer may be dynamically modified to include visual information and assistance to the driver in relation to the vehicle's engine speed (i.e., revolution speed of the vehicle's crankshaft). The tachometer may include one or a combination of: dynamic shift point indicators, a target engine speed range indicator, an overspeed indicator, and a power take-off mode indicator.Type: GrantFiled: October 9, 2020Date of Patent: November 28, 2023Assignee: PACCAR Inc.Inventors: Steven Karl Jahns, Ryan Anthony Reed, Jonathan Scott Duncan, Josef Lotz, Tristan Thomas Pyle, Derek Scott Sancer, Jon Forrest Acton, Jacob Michael White, Hervé Jen Raymond Cecchi, David Michael Gauch, Anna-Magdalena Schatz
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Publication number: 20230372119Abstract: The present disclosure relates to a spinal implant. The spinal implant may be used for lateral insertion into an intervertebral disc space. For example, the spinal implant may include a spacer body to which a plate is fixed. The intervertebral spacer body may include a pair of opposite sides having a pyramid-shaped teeth to fuse to bone. The plate defines at least one upper and lower borehole that each receives a screw. Each screw attaches the plate to a vertebral body between which the intervertebral spacer body is inserted. The boreholes may include locking threads that are adapted to lock the screws into place by engaging complementary locking threads of head of the screw.Type: ApplicationFiled: May 23, 2023Publication date: November 23, 2023Inventors: Lawton Laurence, Sean Saidha, Michael White, Khawar Mohammad Siddique, Brian Regis Perri
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Patent number: D1013167Type: GrantFiled: February 18, 2022Date of Patent: January 30, 2024Assignee: MiRus, LLCInventor: Jared Michael White