Abstract: Disclosed herein are dosing regimens for the administration of a compound of Formula I: or pharmaceutically acceptable salt thereof, or in combination with one or more of a second therapeutic agent, to a patient in need of such treatment.

Abstract: A combustor assembly for a gas turbine engine includes an outer liner that at least partially defines a combustion chamber. The outer liner extends between an aft end and a forward end generally along an axial direction within an outer casing of the gas turbine engine. The outer liner includes an inner surface facing the combustion chamber and an outer surface facing away from the combustion chamber. The combustor assembly includes a radial damper assembly disposed against the outer liner at a plurality of circumferential points.

Abstract: The present invention provides compositions comprising a recombinant AAV and one or more pharmaceutically acceptable excipients. The compositions have improved stability and shelf life as compared to other AAV compositions.

Abstract: The present disclosure generally relates to partial integrated core-shell investment casting molds that can be assembled into complete molds. Each section of the partial mold may contain both a portion of a core and portion of a shell. Each section can then be assembled into a mold for casting of a metal part. The partial integrated core-shell investment casting molds and the complete molds may be provided with filament structures corresponding to cooling hole patterns on the surface of the turbine blade or the stator vane, which provides a leaching pathway for the core portion after metal casting. The invention also relates to core filaments that can be used to supplement the leaching pathway, for example in a core tip portion of the mold.

Abstract: A Z-fold convertible top has a frame supporting a textile cover. The frame includes support in the form of at least one of a pair of pivoted rails rigidly mounted to a bow, stabilizing other pivoted rails. The stability may be employed to displace a quarter window with the rail in a manner that provides a compact top stack packaged in the vehicle body. The stability is also employed to coordinate sealing engagement of the quarter window with a cloth control link pivoted to the vehicle body ground, but displacing the cloth away from the window during retraction. A worm link may enhance interaction between the cloth control link and the rail supporting a quarter window.

Abstract: A Z-fold convertible top has a frame supporting a textile cover. The frame includes support in the form of at least one of a pair of pivoted rails rigidly mounted to a bow, stabilizing other pivoted rails. The stability may be employed to displace a quarter window with the rail in a manner that provides a compact top stack packaged in the vehicle body. The stability is also employed to coordinate sealing engagement of the quarter window with a cloth control link pivoted to the vehicle body ground, but displacing the cloth away from the window during retraction. A worm link may enhance interaction between the cloth control link and the rail supporting a quarter window.

Abstract: A removable top system for a vehicle having a front removable roof section and a rear removable roof section. Different removable roof coverings may be interchangeably combined to provide a complete roof for a sport utility vehicle having a permanent hoop dividing the front and rear roof sections. Soft top and hard top roof coverings are selectively provided. Different retraction mechanisms are disclosed for retracting and storing the removable roof sections.

Abstract: A cargo container for a vehicle including an enclosure or movable supporting member that is connected by a linkage to the vehicle. The linkage may be used to shift the enclosure between a transport position above the roof and a loading position behind the vehicle. The linkage has a right side and a left side. Each side has a forward member that translates the front end of the enclosure in the fore-and-aft direction. A rearward pivoting member lifts portions of the enclosure behind the forward member upwardly to clear a rear corner of the vehicle as the enclosure is moved between the transport position and the loading position.

Abstract: A removable top assembly for a vehicle and method of providing a removable top cover for a vehicle is provided. The removable top assembly includes a fabric cover over a frame. The frame includes a rear bow that is pivotally connected on opposite sides to side rails and a C-pillar. A one bow is latched to a fixed transverse beam. A two bow is detachably secured to right and left side rails that are in turn attached to right and left fixed side beams of the vehicle.

Abstract: A retractable roof assembly for a vehicle is provided that includes relatively movable rigid panels that are positioned to cover a passenger/cargo compartment of the vehicle in an extended position and that are stacked one above another in a retracted position. A telescoping track is provided on opposite lateral sides of the vehicle to guide movement of the roof panels. D-pillars of the roof assembly are slidable between a position wherein they are spaced from the C-pillars to a retracted position in which the D-pillars are adjacent to the C-pillars. Side windows of the vehicle are retracted into the rear quarter panel area of the vehicle.

Abstract: A preferred embodiment of a convertible roof system for an automotive vehicle includes a convertible roof that covers the vehicle essentially from a front header to a rearmost body panel. A further aspect of the present invention provides a forward top stack linkage mechanism, which when actuated, moves a forwardmost roof bow in such a manner that a surface of the roof bow faces upwardly when the top stack is positioned in an extended position and in a retracted position.

Abstract: A convertible roof actuation mechanism includes at least a forward bow, a power actuated rearmost bow and an intermediate bow. A linkage set separately connects the rearmost bow to the intermediate bow. When the forward bow is latched and as the rearmost bow is rearwardly rotated, the linkage set rotates the intermediate bow to tension the roof cover.

Abstract: A composition and a process for producing the composition are disclosed. The composition comprises an alphahydroxyacid and one or more metals in which the metal is present in lower than about 1,000 ?g/kg of the composition. The process comprising contacting an acidic ion exchange resin with an aqueous composition comprising a soluble alphahydroxyacid and a total metal concentration, individual metal concentration, or both, higher than that desired to produce a resin-treated alphahydroxyacid solution having reduced total metal concentration. Also disclosed is a process that can be used for cleaning or removing residues from semiconductor substrates and/or equipment by using a solution, which comprises an alphahydroxyacid.

Abstract: A hardtop convertible roof for a vehicle includes rigid panels that are interconnected to one another to selectively cover the passenger compartment. The roof panels rearward of a forwardmost roof panel are directly pivotally connected to a single pair of brackets which are fixedly connected to opposite sides of the vehicle. An interior surface of a third roof panel faces a majority of an exterior surface of a second roof panel when the roof panels are in a stowed position. The rearmost two roof panels form an at least four-bar linkage and a moveable link interconnecting the two panels is positioned between the majority of portions of the rearmost panels and the pivotal connections of these panels to a fixed location.

Abstract: A removable top system for a vehicle having a front removable roof section and a rear removable roof section. Different removable roof coverings may be interchangeably combined to provide a complete roof for a sport utility vehicle having a permanent hoop dividing the front and rear roof sections. Soft top and hard top roof coverings are selectively provided. Different retraction mechanisms are disclosed for retracting and storing the removable roof sections.

Abstract: A tonneau panel mechanism engages a stationary track in a closed position and disengages from the stationary track when in the open position. The tonneau panel exhibits a first stage of motion that includes both pivotal and non-pivotal motion and a second stage of motion that consists of substantially rotational motion about a pivot. The tonneau panel mechanism can include a linkage assembly with at least one link that engages with a stop on the tonneau panel to alter the motion of the tonneau panel between the first and second stages of motion. The tonneau panel can also use an at least four-bar linkage wherein at least two of the links move relative to one another during the first stage of motion and are locked together during a second stage of motion.

Abstract: A two-way opening modular decklid assembly is disclosed. The modular decklid assembly includes a frame and a decklid that are installed in a vehicle as a modular unit. The decklid assembly uses a simple at least four-bar non-scissor linkage assembly to attach a frame to the vehicle. The linkage assembly is operable to move the frame between open and closed positions.

Abstract: A convertible roof actuation mechanism includes at least a forward bow, a power actuated rearmost bow and an intermediate bow. A linkage set separately connects the rearmost bow to the intermediate bow. When the forward bow is latched and as the rearmost bow is rearwardly rotated, the linkage set rotates the intermediate bow to tension the roof cover.

Abstract: A tonneau panel mechanism engages a stationary track in a closed position and disengages from the stationary track when in the open position. The tonneau panel exhibits a first stage of motion that includes both pivotal and non-pivotal motion and a second stage of motion that consists of substantially rotational motion about a pivot. The tonneau panel mechanism can include a linkage assembly with at least one link that engages with a stop on the tonneau panel to alter the motion of the tonneau panel between the first and second stages of motion. The tonneau panel can also use an at least four-bar linkage wherein at least two of the links move relative to one another during the first stage of motion and are locked together during a second stage of motion.

Abstract: A two-way opening modular decklid assembly is disclosed. The modular decklid assembly includes a frame and a decklid that are installed in a vehicle as a modular unit. The decklid assembly uses a simple at least four-bar non-scissor linkage assembly to attach a frame to the vehicle. The linkage assembly is operable to move the frame between open and closed positions.