Abstract: Binding members for sodium channel Nav1.7 and their use in medicine including for treatment of pain or epilepsy. Binding members comprise a fusion protein containing a Nav1.7-binding peptide, e.g., venom toxin peptide or knottin (“donor diversity scaffold domain”) inserted within an antibody variable domain (“recipient diversity scaffold domain”), and a partner domain (e.g., antibody variable domain), optionally wherein the partner domain enhances specificity of binding to Nav1.7 over other sodium channels.

Abstract: A delivery device for smokable cannabis and a manufacturing method for same with a defined active cannabis compound. Plant material from a plurality of cannabis plants representing a plurality of cannabis cultivars is harvested based on parent cultivars' active cannabis compound profile. Plant material is shredded to a size range applicable to loading into a smokable device, measured proportions of plant materials are combined to produce a mixed batch with a projected desirable active cannabis compound profile. Material is then processed, analyzed, loaded into smokable delivery device, labeled and distributed.

Abstract: A cannabis-based therapeutic product for treatment of chronic pain produced by separating hash resin from plant material of the cannabis plant, pressing the hash resin to expel oil, leaving spent hash resin, extracting further cannabinoids from the spent hash resin using MCT oil, separating the cannabis compounds from the oils using high pressure liquid chromatography, flash chromatography, or similar techniques, and processing selected cannabis compound formulations into a pill, tablet, liquid, or other form suitable for administration as a therapeutic product for treatment of chronic pain, optionally with the further step of enriching the product with a formulation comprising at least 1% by weight purified ?-myrcene, prior to processing into a final product.

Abstract: A cannabis based therapeutic product for treatment of chronic pain produced by separating hash resin from plant material of the cannabis plant, pressing the hash resin to expel oil, leaving spent hash resin, extracting further cannabinoids from the spent hash resin using MCT oil, separating the cannabis compounds from the oils using high pressure liquid chromatography, flash chromatography, or similar techniques, and processing selected cannabis compound formulations into a pill, tablet, liquid, or other form suitable for administration as a therapeutic product for treatment of chronic pain, optionally with the further step of enriching the product with a formulation comprising at least 1% by weight purified -myrcene, prior to processing into a final product.

Abstract: A delivery device for smokable cannabis and a manufacturing method for same with a defined active cannabis compound. Plant material from a plurality of cannabis plants representing a plurality of cannabis cultivars is harvested based on parent cultivars' active cannabis compound profile. Plant material is shredded to a size range applicable to loading into a smokable device, measured proportions of plant materials are combined to produce a mixed batch with a projected desirable active cannabis compound profile. Material is then processed, analyzed, loaded into smokable delivery device, labeled and distributed.

Abstract: A cannabis based therapeutic product for treatment of chronic pain produced by separating hash resin from plant material of the cannabis plant, pressing the hash resin to expel oil, leaving spent hash resin, extracting further cannabinoids from the spent hash resin using MCT oil, separating the cannabis compounds from the oils using high pressure liquid chromatography, flash chromatography, or similar techniques, and processing selected cannabis compound formulations into a pill, tablet, liquid, or other form suitable for administration as a therapeutic product for treatment of chronic pain, optionally with the further step of enriching the product with a formulation comprising at least 1% by weight purified -myrcene, prior to processing into a final product.

Abstract: An airfoil for a gas turbine engine is provided that includes a first sidewall and a second sidewall coupled together at a leading edge and a trailing edge, such that a cavity is defined therebetween. A central plenum and an impingement chamber are defined within the cavity. The central plenum channels cooling fluid to the impingement chamber where cooling fluid impinges on the sidewalls. Cooling fluid is discharged from the impingement chamber via film cooling holes.