Abstract: Methods and related devices for impinging light on tissue, for example within a body of a patient, to induce various biological effects are disclosed. Biological effects may include at least one of inactivating and/or inhibiting growth of one or more pathogens, upregulating a local immune response, stimulating enzymatic generation of nitric oxide to increase endogenous stores of nitric oxide, releasing nitric oxide from endogenous stores of nitric oxide, and inducing an anti-inflammatory effect. Wavelengths of light are selected based on intended biological effects for one or more of targeted tissue types and targeted pathogens. Light treatments may provide multiple pathogenic biological effects, either with light of a single wavelength or with light having multiple wavelengths. Devices and methods for light treatments are disclosed that provide light doses for inducing biological effects on various targeted pathogens and targeted tissues with increased efficacy and reduced cytotoxicity.

Abstract: A system and method for generating a plurality of short RF pulses. The system and method comprises a first circuit comprising a first power supply and a plurality of first networks for generating a first output signal in a form of a high voltage pedestal pulse supplied to a common node, and a second circuit comprising a second power supply and a plurality of second networks for generating a second output signal in a form of a high voltage short pulse which is supplied to the common node. The pedestal pulse passes through a blocking inductor before being combined with the short pulse at the common node, and the short pulse is stacked on top of the pedestal pulse to form a combined high voltage pulse. A low frequency magnetron is coupled to the common node for receiving the stacked combined high voltage pulse and generating a short RF pulse.

Abstract: An end cap is supported by a retractable holding mechanism between an edge press and tube end. A pick up mandrel and extender are mounted in the edge press head. The pick up mandrel is extendible from the edge press to contact the end cap. Non-mechanical means on the pick up mandrel secure the cap to the pick up mandrel while the holding mechanism is retracted. The pick up mandrel carries the end cap to the tube end. The extender is collapsed under pressure of the edge press, allowing it to contact the skirt of the cap and press it into the tube end. The pickup mandrel is retracted into the edge press head, releasing its grip on the end cap, and the edge press head and pickup mandrel are retracted for another cycle.