Patents by Inventor Michael William McKechney

Michael William McKechney has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Oxazolyl-acid amide derivatives useful as inhibitors of PDE4 isozymes
    Patent number: 6894041
    Abstract: This application is directed to compounds useful as inhibitors of PDE4 in the treatment of diseases regulated by the activation and degranulation of eosinophils, especially asthma, chronic bronchitis, and chronic obstructuive pulmonary disease, of the formula: where Y is ?C(R1a)— or —[N(O)k]— where k is 0 or 1; G1 is a saturated or unsaturated carbon ring system that is a 3- to 7-membered monocyclic, or that is a 7- to 12-membered, fused polycyclic; provided that G1 is not a discontinuous or restricted biaryl moiety as defined under G2; where optionally one carbon atom may be replaced by a heteroatom selected from N, O, and S; where optionally a second carbon atom thereof, and further optionally a third carbon atom thereof may be replaced by N; —G2 is a saturated or unsaturated carbon ring system that is a 3- to 7-membered monocyclic; or that is a 7- to 12-membered, fused polycyclic; or that is a 7- to 18-membered discontinuous or restricted biaryl moiety; wherein for each of the carbon ring systems recit
    Type: Grant
    Filed: November 20, 2002
    Date of Patent: May 17, 2005
    Assignee: Pfizer Inc
    Inventors: Anthony Marfat, Michael William McKechney
  • Pyrrolyl-and imidazolyl-acid amide derivatives useful as inhibitors of PDE4 isozymes
    Patent number: 6869945
    Abstract: This application is directed to compounds useful as inhibitors of PDE4 in the treatment of diseases regulated by the activation and degranulation of eosinophils, especially asthma, chronic bronchitis, and chronic obstructuive pulmonary disease, of the formula: where Y is ?C(R1a)— or —[N?(O)k]— where k is 0 or 1; G1 is a saturated or unsaturated carbon ring system that is a 3- to 7-membered monocyclic, or that is a 7- to 12-membered, fused polycyclic; provided that G1 is not a discontinuous or restricted biaryl moiety as defined under G2; where optionally one carbon atom may be replaced by a heteroatom selected from N, O, and S; where optionally a second carbon atom thereof, and further optionally a third carbon atom thereof may be replaced by N; -G2 is a saturated or unsaturated carbon ring system that is a 3- to 7-membered monocyclic; or that is a 7- to 12-membered, fused polycyclic; or that is a 7- to 18-membered discontinuous or restricted biaryl moiety; wherein for each of the carbon ring systems re
    Type: Grant
    Filed: November 20, 2002
    Date of Patent: March 22, 2005
    Assignee: Pfizer Inc
    Inventors: Anthony Marfat, Michael William McKechney
  • Pyrrolyl- and imidazolyl-acid amide derivatives useful as inhibitors of PDE4 isozymes
    Publication number: 20030186974
    Abstract: Compounds useful as inhibitors of PDE4 in the treatment of diseases regulated by the activation and degranulation of eosinophils, especially asthma, chronic bronchitis, and chronic obstructuive pulmonary disease, of the formula: 1
    Type: Application
    Filed: November 20, 2002
    Publication date: October 2, 2003
    Inventors: Anthony Marfat, Michael William McKechney
  • Oxazolyl-acid amide derivatives useful as inhibitors of PDE4 isozymes
    Publication number: 20030130254
    Abstract: Compounds useful as inhibitors of PDE4 in the treatment of diseases regulated by the activation and degranulation of eosinophils, especially asthma, chronic bronchitis, and chronic obstructuive pulmonary disease, of the formula: 1
    Type: Application
    Filed: November 20, 2002
    Publication date: July 10, 2003
    Inventors: Anthony Marfat, Michael William McKechney
  • Thiazolyl-acid amide derivatives useful as inhibitors of PDE4 isozymes
    Patent number: 6559168
    Abstract: This application is directed to compounds useful as inhibitors of PDE4 in the treatment of diseases regulated by the activation and degranulation of eosinophils, especially asthma, chronic bronchitis, and chronic obstructuive pulmonary disease, of the formula: where Y is ═C(R1a)— or —[N□(O)k]— where k is 0 or 1; G1 is a saturated or unsaturated carbon ring system that is a 3- to 7-membered monocyclic, or that is a 7- to 12-membered, fused polycyclic; provided that G1 is not a discontinuous or restricted biaryl moiety as defined under G2; where optionally one carbon atom may be replaced by a heteroatom selected from N, O, and S; where optionally a second carbon atom thereof, and further optionally a third carbon atom thereof may be replaced by N; —G2 is a saturated or unsaturated carbon ring system that is a 3- to 7-membered monocyclic; or that is a 7- to 12-membered, fused polycyclic; or that is a 7- to 18-membered discontinuous or restricted bi
    Type: Grant
    Filed: January 31, 2002
    Date of Patent: May 6, 2003
    Assignee: Pfizer Inc
    Inventors: Anthony Marfat, Michael William McKechney
  • Thiazolyl-, oxazolyl-, pyrrolyl-, and imidazolyl-acid amide derivatives useful as inhibitors of PDE4 isozymes
    Publication number: 20020123520
    Abstract: Compounds useful as inhibitors of PDE4 in the treatment of diseases regulated by the activation and degranulation of eosinophils, especially asthma, chronic bronchitis, and chronic obstructuive pulmonary disease, of the formula: 1
    Type: Application
    Filed: January 31, 2002
    Publication date: September 5, 2002
    Applicant: Pfizer Inc.
    Inventors: Anthony Marfat, Michael William McKechney