Patents by Inventor Michael William Pennington

Michael William Pennington has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANALOGS OF SHK TOXIN AND THEIR USES IN SELECTIVE INHIBITION OF KV1. 3 POTASSIUM CHANNELS
    Publication number: 20170274047
    Abstract: Analogs of ShK toxin and methods for using such ShK analogs. The ShK analogs generally comprise ShK toxin attached to a chemical entity (e.g. an atom, molecule, group, residue, compound, moiety, etc.) that has an anionic charge. In some embodiments, the chemical entity attached to the ShK toxin may comprise an amino acid residue. The ShK analogs may be administered to human or non-human animal subjects to cause inhibition of potassium channels or to otherwise treat diseases or disorders. In some embodiments, the chemical entity to which the ShK toxin is attached may be chosen to provide selective inhibition of certain potassium channels (e.g., Kv1.3 channels) over other potassium channels (e.g., Kv1.1 channels). In come embodiments, the chemical entity to which the ShK toxin is attached may include a fluorophore, thereby providing a fluorophore tagged ShK analog.
    Type: Application
    Filed: February 28, 2017
    Publication date: September 28, 2017
    Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, BACHEM AMERICAS, INC.
    Inventors: K. George Chandy, Christine Beeton, Michael William Pennington
  • Analogs of ShK toxin and their uses in selective inhibition of Kv1.3 potassium channels
    Patent number: 8440621
    Abstract: Analogs of ShK toxin and methods for using such ShK analogs. The ShK analogs generally comprise ShK toxin attached to a chemical entity (e.g. an atom, molecule, group, residue, compound, moiety, etc.) that has an anionic charge. The ShK analogs may be administered to human or non-human animal subjects to cause inhibition of potassium channels or to otherwise treat diseases or disorders. In some embodiments, the chemical entity to which the ShK toxin is attached may be chosen to provide selective inhibition of certain potassium channels (e.g., Kv1.3 channels) over other potassium channels (e.g., Kv1.1 channels). In come embodiments, the chemical entity to which the ShK toxin is attached may include a fluorophore and such fluorophore-tagged ShK analogs may be used in flow cytometry alone, or in conjunction with class II tetramers that can detect autoreactive cells.
    Type: Grant
    Filed: November 1, 2011
    Date of Patent: May 14, 2013
    Assignees: The Regents of the University of California, Bachem Biosciences, Inc.
    Inventors: George K. Chandy, Christine Beeton, Michael William Pennington
  • Analogs of ShK Toxin and their Uses in Selective Inhibition of Kv1.3 Potassium Channels
    Publication number: 20120142600
    Abstract: Analogs of ShK toxin and methods for using such ShK analogs. The ShK analogs generally comprise ShK toxin attached to a chemical entity (e.g. an atom, molecule, group, residue, compound, moiety, etc.) that has an anionic charge. The ShK analogs may be administered to human or non-human animal subjects to cause inhibition of potassium channels or to otherwise treat diseases or disorders. In some embodiments, the chemical entity to which the ShK toxin is attached may be chosen to provide selective inhibition of certain potassium channels (e.g., Kv1.3 channels) over other potassium channels (e.g., Kv1.1 channels). In come embodiments, the chemical entity to which the ShK toxin is attached may include a fluorophore and such fluorophore-tagged ShK analogs may be used in flow cytometry alone, or in conjunction with class II tetramers that can detect autoreactive cells.
    Type: Application
    Filed: November 1, 2011
    Publication date: June 7, 2012
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Christine Beeton, George K. Chandy, Michael William Pennington
  • Analogs of ShK toxin and their uses in selective inhibition of Kv1.3 potassium channels
    Patent number: 8080523
    Abstract: Analogs of ShK toxin and methods for using such ShK analogs. The ShK analogs generally comprise ShK toxin attached to a chemical entity (e.g. an atom, molecule, group, residue, compound, moiety, etc.) that has an anionic charge. In some embodiments the chemical entity attached to the ShK toxin may comprise an amino acid residue. The ShK analogs may be administered to human or non-human animal subjects to cause inhibition of potassium channels or to otherwise treat diseases or disorders. In some embodiments, the chemical entity to which the ShK toxin is attached may be chosen to provide selective inhibition of certain potassium channels (e.g., Kv1.3 channels) over other potassium channels (e.g., Kv1.1 channels). In come embodiments, the chemical entity to which the ShK toxin is attached may include a fluorophore, thereby providing a fluorophore tagged ShK analog.
    Type: Grant
    Filed: October 7, 2005
    Date of Patent: December 20, 2011
    Assignee: The Regents of the University of California
    Inventors: Christine Beeton, George K. Chandy, Michael William Pennington