Abstract: A system for an aircraft includes an engine bleed source of a gas turbine engine. The system also includes a means for chilling an engine bleed air flow from the engine bleed source to produce a chilled working fluid. The system further includes a means for providing the chilled working fluid for an aircraft use.

Abstract: A system includes a recirculation line, a mainline flow meter operable to measure a flowrate of fluid flowing through the recirculation line, a mixing chamber, an inlet line coupled between the recirculation line and the mixing chamber, at least one chemical injection port coupled to the inlet line, a dedicated feed pump operably associated with each chemical injection port, and an outlet line coupled between the mixing chamber and the recirculation line. The mixing chamber includes a plurality of mixing zones, a mixing blade assembly that includes at least one blade within each mixing zone, and a motor coupled to the mixing blade assembly and operable to rotate the mixing blade assembly. Each of the dedicated feed pumps is coupled to a separate chemical supply and is operable to pump a chemical to the corresponding chemical injection port for injection into the inlet line.

Abstract: A system includes a recirculation line, a mainline flow meter operable to measure a flowrate of fluid flowing through the recirculation line, a mixing chamber, an inlet line coupled between the recirculation line and the mixing chamber, at least one chemical injection port coupled to the inlet line, a dedicated feed pump operably associated with each chemical injection port, and an outlet line coupled between the mixing chamber and the recirculation line. The mixing chamber includes a plurality of mixing zones, a mixing blade assembly that includes at least one blade within each mixing zone, and a motor coupled to the mixing blade assembly and operable to rotate the mixing blade assembly. Each of the dedicated feed pumps is coupled to a separate chemical supply and is operable to pump a chemical to the corresponding chemical injection port for injection into the inlet line.

Abstract: A method is described for producing a pneumococcal capsular polysaccharide protein conjugate in which one or more activated pneumococcal polysaccharides of particular pneumococcal serotypes and carrier protein are separately lyophilized in the form of lyospheres of carrier protein and lyospheres of the one or more polysaccharides. A predetermined amount of carrier protein lyospheres and activated polysaccharide lyospheres are mixed together and the mixture reconstituted in an organic solvent to produce polysaccharide carrier protein conjugates. A plurality of conjugates, each comprising polysaccharides of a particular serotype, may be used to produce multivalent pneumococcal immunogenic compositions having a combination of conjugates for use in vaccines.

Abstract: An after-fan system for an engine may comprise an after-fan turbine an electrical generator operationally coupled to the after-fan turbine, and an electric motor electrically coupled to the electrical generator. The electrical generator may be configured to generate an electrical current in response to rotation of the after-fan turbine. The electric motor may be configured to generate torque.

Abstract: This document relates to employing tongue gestures to control a computing device, and training machine learning models to detect tongue gestures. One example relates to a method or technique that can include receiving one or more motion signals from an inertial sensor. The method or technique can also include detecting a tongue gesture based at least on the one or more motion signals, and outputting the tongue gesture.

Abstract: Methods and systems for rotationally aligning a commissure of a prosthetic heart valve with a commissure of a native valve are disclosed. In some examples, a method can include advancing a distal end portion of an assembly toward a native heart valve, the assembly comprising a delivery apparatus and a prosthetic heart valve, and including one or more radiopaque markers, where one radiopaque marker is suspended within a cell of a frame of the prosthetic heart valve and aligned with a commissure of the prosthetic heart valve. The method further includes receiving a fluoroscopic image in a selected imaging view of the prosthetic heart valve on the delivery apparatus, determining, based on the fluoroscopic image and the one or more radiopaque markers, whether the prosthetic heart valve is in a desired rotational orientation, and rotating the assembly until the prosthetic heart valve is in the desired rotational orientation.

Abstract: Hybrid electric propulsion systems are described. The systems include a gas turbine engine having low and high speed spools, each spool having a respective compressor and turbine. A mechanical power transmission is configured to at least one of extract power from and supply power to at least one of the low speed spool and the high speed spool, an electric machine is configured to augment rotational power of at least one of the spools, and a controller is operable to determine a rotational speed of the low speed spool, determine a rotational speed of the high speed spool, determine if a predetermined operational zone of operation based on the determined rotational speeds is present, and when a predetermined operational zone is determined, control a power augmentation of at least one spool to limit dwell operation of the gas turbine engine within the predetermined operational zone.

Abstract: This document relates to employing biosignals to evaluate predictions made by predictive models. For example, user attention can be inferred from a user attention signal such as gaze. When the user directs attention to a prediction output by a given predictive model, a user reaction signal such as an electroencephalogram or pupillary diameter measurement can be processed to determine whether the user perceives an error. If the user perceives an error, an error indication can be output. Error indications can be used to evaluate the predictive model, replace predictions generated by the predictive model, train the predictive model, etc.

Abstract: A process for separating a Cs or C6 alkanediol from a crude product stream comprising the Cs or C6 alkanediol, light contaminants and heavy contaminants comprising one or more of: a C 10 or C 12 linear ester, or a C 10 or C 12 cyclic acetal or ketal is disclosed. The process comprises feeding the crude product stream to a separation system comprising a first distillation zone, to which the crude product stream is fed and from which the heavy contaminants are removed in a heavies stream taken as a bottom stream, and a second distillation zone, in which the Cs or C6 alkanediol is separated from a reaction product, comprising one or more of: a Cs or C6 cyclic ester, or a Cs or C6 aldehyde, formed in the first distillation zone and from which the Cs or C6 alkanediol is withdrawn in a refined product stream.

Abstract: An engine system of an aircraft includes an energy storage system, a gas turbine engine, and a controller. The gas turbine engine includes a low spool, a high spool, a low-spool generator operably coupled to the low spool, and a high-spool electric motor operably coupled to the high spool. The controller is configured to detect a braking condition of the aircraft, transfer power from the low-spool generator to the energy storage system based on the storage capacity state of the energy storage system, and transfer power to the high spool through the high-spool electric motor to support combustion in the gas turbine engine while a rotational speed of the low spool is reduced responsive to the low-spool generator extracting energy from the low spool.

Abstract: A method is described for producing a pneumococcal capsular polysaccharide protein conjugate in which one or more activated pneumococcal polysaccharides of particular pneumococcal serotypes and carrier protein are separately lyophilized, the separately lyophilized polysaccharides and carrier protein are separately reconstituted in an organic solvent, and the reconstituted polysaccharide and carrier protein are then combined together by Tee-mixing and conjugated together to produce polysaccharide carrier protein conjugates. A plurality of conjugates, each comprising polysaccharides of a particular serotype, may be used to produce multivalent pneumococcal immunogenic compositions having a combination of conjugates for use in vaccines.

Abstract: A laser hole drilling system includes a laser source that generates a laser beam along an optical axis; a spherical lens along the optical axis downstream of the laser source; and a control system in communication with the spherical lens and the laser source, the control system operable to locate the spherical lens with respect to the laser source to produce a light distribution in polar coordinates of a real portion of the Fourier Transform to generate an asymmetric teardrop shaped energy distribution at a focal plane.

Abstract: Methods and systems for attaching a radiopaque marker to a prosthetic heart valve to indicate a location of a commissure of the prosthetic heart valve are disclosed. As one example, a prosthetic heart valve can include a frame, a plurality of leaflets arranged within the frame, and at least one commissure comprising an attachment member comprising a central portion and a flap extending outward from the central portion, the flap folded over a radially outward facing side of the central portion, and the attachment member arranged across a selected cell of the frame. The commissure further comprises commissure tabs of two adjacent leaflets coupled to a radially inward facing side of the central portion, and a radiopaque marker arranged on the flap of the attachment member, between the flap and the radially outward facing side of the central portion.

Abstract: This document relates to employing tongue gestures to control a computing device, and training machine learning models to detect tongue gestures. One example relates to a method or technique that can include receiving one or more motion signals from an inertial sensor. The method or technique can also include detecting a tongue gesture based at least on the one or more motion signals, and outputting the tongue gesture.

Abstract: An after-fan system for a gas turbine engine includes a variable pitch fan exit guide vane array. An after-fan turbine downstream of the variable pitch fan exit guide vane array and a control operable to vary a pitch of the variable fan exit guide vane array. A method of generating thrust for a gas turbine engine includes rotating a fan section with an array of fan blades; rotating an after-fan turbine downstream of the fan section; and varying a pitch of a variable fan exit guide vane array downstream of the fan section and upstream of the after-fan turbine.

Abstract: A method is described for producing a pneumococcal capsular polysaccharide protein conjugate in which one or more activated pneumococcal polysaccharides of particular pneumococcal serotypes and carrier protein are separately lyophilized, the separately lyophilized polysaccharides and carrier protein are separately reconstituted in an organic solvent, and the reconstituted polysaccharide and carrier protein are then combined together by Tee-mixing and conjugated together to produce polysaccharide carrier protein conjugates. A plurality of conjugates, each comprising polysaccharides of a particular serotype, may be used to produce multivalent pneumococcal immunogenic compositions having a combination of conjugates for use in vaccines.

Abstract: Methods and systems for attaching a radiopaque marker to a prosthetic heart valve to indicate a location of a commissure of the prosthetic heart valve are disclosed. As one example, a prosthetic heart valve includes a frame including a plurality of struts forming a plurality of cells of the frame arranged between an inflow end and an outflow end of the frame, a plurality of leaflets arranged within the frame, and at least one commissure comprising an attachment member arranged across a selected cell of the plurality of cells of the frame and commissure tabs of two adjacent leaflets coupled to the attachment member. The valve further includes a radiopaque marker arranged on the attachment member of the commissure within the selected cell.

Abstract: This document relates to employing tongue gestures to control a computing device, and training machine learning models to detect tongue gestures. One example relates to a method or technique that can include receiving one or more motion signals from an inertial sensor. The method or technique can also include detecting a tongue gesture based at least on the one or more motion signals, and outputting the tongue gesture.

Abstract: Methods and systems for attaching a radiopaque marker to a prosthetic heart valve to indicate a location of a commissure of the prosthetic heart valve are disclosed. As one example, a prosthetic heart valve can include a frame, a plurality of leaflets arranged within the frame, and at least one commissure comprising an attachment member comprising a central portion and a flap extending outward from the central portion, the flap folded over a radially outward facing side of the central portion, and the attachment member arranged across a selected cell of the frame. The commissure further comprises commissure tabs of two adjacent leaflets coupled to a radially inward facing side of the central portion, and a radiopaque marker arranged on the flap of the attachment member, between the flap and the radially outward facing side of the central portion.