Abstract: Provided are methods of identifying a compound that binds to or modulates an activity of a CTCF polypeptide or CTCF polypeptide complex. Also provided are methods of monitoring a cancer state of a cell by detecting a chromatin boundary proximal to a tumor suppressor gene of the cell and by monitoring the formation of a gene-specific CTCF polypeptide complex in the cell. In addition, methods of selecting a treatment or determining a prognosis for a cancer related disease are provided. Provided are recombinant cells comprising recombinant CTCF genes, recombinant cells comprising CTCF knock downs or knock outs, and recombinant laboratory animals comprising CTCF knock downs or knock outs.

Abstract: A device for both warming substances and for providing a nightlight. The device can have a single opening in a upper lid portion for allowing various sized containers of substances to be inserted therein. The substances can include lotions, creams, pastes, gels, liquids, and the like. Controls such as rheostats can be adjusted to select desired nightlight intensity levels and desired temperature levels. Timers can adjust when the rheostat settings are to be turned on and off. Visual and/or audible alarms can be activated when selected levels have been reached. The device can have a clock for giving off the current time.