Abstract: The present invention relates to peptides, in particular cell-penetrating peptides, and to conjugates of such cell-penetrating peptides with a therapeutic molecule. The present invention further relates to use of such peptides or conjugates in methods of treatment or as a medicament, especially in the treatment of genetic disorders and in particular muscular dystrophies such as Duchenne muscular dystrophy.

Abstract: A fuel powered paint marker having a first stage and a second stage comprising: a housing; a combustion chamber; a piston; a compression chamber; a fuel system; an oxidizing system; an oxidizing agent; a fuel assembly included in the fuel system; a separation assembly included in the fuel system and separating the oxidizing agent from the fuel assembly in the first stage; a bolt drive system; a fuel nozzle included in the fuel system for injecting fuel into the combustion chamber during the second stage; and, an ignition for igniting the fuel and oxidating agent in the combustion chamber driving the piston forward and compressing a gas in the compression chamber thereby ejecting a projectile wherein the fuel and oxidizing agent are separated during the first stage and mixed in the combustion chamber.

Abstract: An integrated circuit (IC) device includes a transistor channel region within (and over a base of) a semiconductor fin, a gate structure over the fin, an isolation or dielectric material adjacent the base of the fin, and an intervening spacer material adjacent the fin, over the dielectric material, and between the channel region (and gate structure) and the isolation or dielectric material. The intervening spacer material may be at substantially equal heights on both sides of the fin. The intervening spacer material may have a height or thickness that is substantial portion of the height of the fin. The spacer and isolation materials may be on both sides of the fin, and between the fin and adjacent fins.

Abstract: Techniques are described for a behavioral analysis of metadata associated with source code to identify malicious source code. For example, this disclosure describes a computing system configured to obtain metadata associated with source code of a software package. The computing system is also configured to determine, based on the metadata associated with source code, whether there are any anomalies associated with the source code. The computing system is further configured to, in response to determining that there is at least one anomaly associated with the source code, compute a score for the software package. The computing system is also configured to perform an action based on the score for the software package.

Abstract: A computer implemented method is provided. A number of processor units identify a number of certificates for a device within a network to obtain a file path for each certificate. The number of processor units perform an internal scan of the device to obtain a port number for each active port associated with network protocol on the device. The number of processor units identify a certificate chain associated with each port number based on the network protocol for the device. The number of processor units compare content for each certificate from the number of certificates to the certificate chains for the device to generate a number of matches. The number of processor units generate a data structure including the file path of the certificate for each port on the device based on the number of matches.

Abstract: Techniques for using a language model (e.g., a large language model (LLM)) to generate a natural language response to a user input and prosody information (e.g., voice characteristics associated with a synthetic voice to output the natural language response to the user) are described. The prosody information may correspond to a natural language (e.g., text or tokenized) description, a spectrogram, and/or a latent representation of the voice characteristic(s) associated with the natural language response. In some embodiments, the natural language response and the prosody information may be generated by different portions of layers of the language model. In such embodiments, the output of the layer(s) of the language model configured to generate the natural language response may be provided to the layer(s) of the language model configured to generate the prosody information and the output may be used to generate the prosody information, and vice versa.

Abstract: The present disclosure provides stable inoculant compositions and methods for enhancing the survival and/or stability of microorganisms in an inoculant composition. In some embodiments, the microorganisms in an inoculant compositions are stabilized by the presence of one or more maltodextrins having a dextrose equivalent value of about 15 to about 20.

Abstract: Provided herein are bioluminescent polypeptides and compositions and methods for the assembly of a tripartite or multipartite bioluminescent complex. In particular embodiments, a bioluminescent complex is formed upon the interaction of three or more peptide and/or polypeptide components.

Abstract: Methods of treating a neurological disorder (such as levodopa induced dyskinesia) by administering a combination of Compound I and fesoterodine.

Abstract: A copolyester is provided comprising: a. at least one terephthalate acid residue; b. about 85 to about 96 mole % of ethylene glycol residues; c. about 4 to about 15 mole % of a combination of 1,4-cyclohexanedimethanol residues (CHDM) and diethylene glycol (DEG) residues; and d. a germanium catalyst present in the copolyester at a concentration of about 5 to about 500 ppm based on elemental germanium; wherein the terephthalate monomer is based on the substantially equal diacid equivalents of 100 mole % to diol equivalence of 100 mole % for a total of 200 mole %.

Abstract: An air conditioned enclosure can include an electronics enclosure with an internal electronics area and an air-conditioner opening into the internal electronics area and an air conditioner. The air conditioner can include an ambient-exchange housing that defines an exchange cavity including a first heat exchanger, a cooling enclosure including a mating surface and first walls that define a cooling cavity having a second heat exchanger, and the mating surface mounted to the electronics enclosure to provide a sealed perimeter around the air-condition opening with cooling cavity aligned for air exchange with the internal electronics area. The cooling enclosure can define a fluid connection between the ambient air exchange cavity and the cooling cavity including a fluid trap extending from the second heat exchanger along a trap height to capture and retain condensate from the second heat exchanger as a barrier to ingress from the exchange cavity into the cooling cavity.

Abstract: Systems, apparatus, articles of manufacture, and methods to facilitate user interaction across multiple computing systems are disclosed. An example apparatus includes interface circuitry, machine readable instructions, and programmable circuitry to at least one of instantiate or execute the machine readable instructions to, cause content to be provided to a host computing system to present the content via a display, access an edit instruction from a user of the apparatus, the edit instruction to cause a change of the content, and cause the edit instruction to be provided to the host computing system to apply the change to the content presented on the display.

Abstract: A gas projectile platform having a trigger that can rotate when pressure is applied to the trigger, a first spool biased against a magnet, a pad assembly that, when actuated, allows pressure to enter an first spool pressure area forward the first spool and configured to release the first spool from the magnet when sufficient pressure is transferred to the first spool pressure area, the first spool configured to transmit pressure to a second spool wherein the second spool is configured to be positioned rearward overcoming a spring force to allow press to release from a bolt pressure area, wherein the bolt pressure area is pressurized when the bolt is in a forward position and configured to transition rearward when the second spool overcomes the spring force and wherein an ejection pressure stored in a bolt pressure area is transmitted to a chamber and ejects a projectile from a barrel.

Abstract: Compounds of the Formula (I), pharmaceutical compositions comprising compounds of the Formula (I), and their use for treating or preventing an infection caused by Human Cytomegalovirus (HCMV), Epstein-Barr virus (EBV), or Human Immunodeficiency Virus (HIV):

Abstract: This system is a pneumatic actuation valve assembly that can include a frame; a timing spool housing; a timing spool carriage; a timing spool; a magnet configured to bias the timing spool in a forward position; a main spool and configured to travel toward a frame forward portion when a fluid is received into a mid-main spool pressure area wherein the main spool actuates a bolt carried by the frame and is configured to receive a projective in an open position and chamber the projective in a closed position; and, a bore defined in the timing spool configured to allow pressure in a rear main spool pressure area to escape through the bore releasing rearward pressure on the timing spool allowing the timing spool to travel from the rearward position to the forward position according to an attraction of the magnet.

Abstract: Systems, methods, and devices described herein provide for operating a lighting fixture with a plurality of light sources at a target chromaticity with a target output spectral power distribution. The methods include multiplying a first spectral power distribution by a second spectral power distribution to determine a product spectral power distribution, multiplying the product spectral power distribution by an illuminant spectral power distribution to determine the target output spectral power distribution at the target chromaticity, and driving the plurality of light sources at intensities corresponding to the target output spectral power distribution.

Abstract: An air conditioner for an enclosure that can include a housing that partly defines an ambient air exchange cavity and a tub that further defines the ambient air exchange cavity and partly defines a cooling cavity. The tub can support a first heat exchanger within the ambient air exchange cavity, and a second heat exchanger and a fan within the cooling cavity. The second heat exchanger can be included in a coolant flow loop with the first heat exchanger and the fan can move air across the second heat exchanger and into the inlet of the enclosure. The second heat exchanger can be located above the fan. A fluid trap can be provided below the second heat exchanger and adjacent the fan to capture condensate from the second heat exchanger and can direct the condensate into the ambient air exchange cavity for disposal.

Abstract: Described are soles for a shoe, in particular for a sports shoe, with a midsole. The midsole includes a first sole region, which includes particle foam. The midsole further includes a deformation region within the midsole, wherein the deformation region has a volume greater than that of a single expanded particle and is positioned so that it allows a sideward deformation of the material of the first sole region under a pressure load on the sole.

Abstract: A computer system is provided that includes a storage system, at least one transceiver, and a processing system with at least one hardware processor. The storage system stores a first list pair. The transceiver receives electronic data messages that each include a respective data transaction request. The processing system determines how the new data transaction request should be processed based on which communication protocol was used to submit the request. Updates regarding the first list pair are sent out to non-party client computer systems using different communication protocols, where one is faster than the other, but the slower update includes private data therein.