Abstract: Organs-on-chips are microfluidic devices for culturing living cells in micrometer sized chambers in order to model physiological functions of tissues and organs. Engineered patterning and continuous fluid flow in these devices has allowed culturing of intestinal cells bearing physiologically relevant features and sustained exposure to bacteria while maintaining cellular viability, thereby allowing study of inflammatory bowl diseases. However, existing intestinal cells do not possess all physiologically relevant subtypes, do not possess the repertoire of genetic variations, or allow for study of other important cellular actors such as immune cells. Use of iPSC-derived epithelium, including IBD patient-specific cells, allows for superior disease modeling by capturing the multi-faceted nature of the disease.

Abstract: According to at least one aspect of the present disclosure, a suspension system for a stroller is provided, the suspension system comprising a shroud having a lower section, an upper section, and a sliding section slidably coupled between the lower section and upper section, the sliding section configured to provide a degree of travel to the lower section and upper section equal to or less than a length of the sliding section; a first spring located at least partially within the lower section; a second spring located at least partially within the upper section; and a washer located between the first spring and the second spring and within the sliding section.

Abstract: An infant highchair is provided. The infant highchair includes a base having a plurality of legs and a footrest positioned between a first and a second leg of the base. The footrest includes two rotators configured to rotate the footrest into a first position for foot support and a second position for foot support. The footrest includes a bottom support having a first planar surface opposite a second planar surface and the two rotators configured to rotate the footrest at least 180°. The footrest includes two locking mechanisms configured to lock the footrest in at least one position for foot support. The footrest includes two release actuators, each release actuator configured to release a respective locking mechanism.

Abstract: An infant highchair is disclosed. The infant highchair includes a seat having a backrest and a locking mechanism fixed to the backrest. The infant highchair includes a harness having a first shoulder strap and a second shoulder strap positioned to come together at the locking mechanism. The locking mechanism is configured to lock the first shoulder strap and the second shoulder strap. The backrest has an internal chamber and an aperture to the internal chamber on a front side of the backrest. The locking mechanism is positioned at the aperture. The first shoulder strap and the second shoulder strap have a portion extending through the aperture into the internal chamber.

Abstract: Organs-on-chips are microfluidic devices for culturing living cells in micrometer sized chambers in order to model physiological functions of tissues and organs. Engineered patterning and continuous fluid flow in these devices has allowed culturing of intestinal cells bearing physiologically relevant features and sustained exposure to bacteria while maintaining cellular viability, thereby allowing study of inflammatory bowl diseases. However, existing intestinal cells do not possess all physiologically relevant subtypes, do not possess the repertoire of genetic variations, or allow for study of other important cellular actors such as immune cells. Use of iPSC-derived epithelium, including IBD patient-specific cells, allows for superior disease modeling by capturing the multi-faceted nature of the disease.

Abstract: Organs-on-chips are microfluidic devices for culturing living cells in micrometer sized chambers in order to model physiological functions of tissues and organs. Engineered patterning and continuous fluid flow in these devices has allowed culturing of intestinal cells bearing physiologically relevant features and sustained exposure to bacteria while maintaining cellular viability, thereby allowing study of inflammatory bowl diseases. However, existing intestinal cells do not possess all physiologically relevant subtypes, do not possess the repertoire of genetic variations, or allow for study of other important cellular actors such as immune cells. Use of iPSC-derived epithelium, including IBD patient-specific cells, allows for superior disease modeling by capturing the multi-faceted nature of the disease.

Abstract: A medical device is configured to detect, based on a reading from the sensor, a state of a first component of the plurality of electronic components, identify a maintenance requirement of the medical device based on the detected state of the first component, restrict a first function of the medical device based on the identified maintenance requirement, transmit the identified maintenance requirement to a server system, receive from the server system an instruction addressing the identified maintenance requirement, receiving a first access request, determine that the first access request is a maintenance access request, and in response to the maintenance access request, display the instruction on a user interface of the medical device.

Abstract: A medical device is configured to store, in a session memory, data regarding operational parameters of the medical device, changes to the parameters, and physiological data of a patient associated with the medical device. A clinician may select, via a user interface of the medical device, a portion of the session memory to a remote device with a request for assistance regarding a problem occurring at the medical device. The portion of the session may be reviewed at the remote device in a graphical copy of a user interface of the medical device as it appeared when the data was recorded, and a workflow is generated at the remote device and sent to the medical device to assist the clinician in resolving issues at the medical device. A session may be started without an identification of the patient or a medical component, and the identification updated at a later time.

Abstract: Organs-on-chips are microfluidic devices for culturing living cells in micrometer sized chambers in order to model physiological functions of tissues and organs. Engineered patterning and continuous fluid flow in these devices has allowed culturing of intestinal cells bearing physiologically relevant features and sustained exposure to bacteria while maintaining cellular viability, thereby allowing study of inflammatory bowl diseases. However, existing intestinal cells do not possess all physiologically relevant subtypes, do not possess the repertoire of genetic variations, or allow for study of other important cellular actors such as immune cells. Use of iPSC-derived epithelium, including IBD patient-specific cells, allows for superior disease modeling by capturing the multi-faceted nature of the disease.

Abstract: Organs-on-chips are microfluidic devices for culturing living cells in micrometer sized chambers in order to model physiological functions of tissues and organs. Engineered patterning and continuous fluid flow in these devices has allowed culturing of intestinal cells bearing physiologically relevant features and sustained exposure to bacteria while maintaining cellular viability, thereby allowing study of inflammatory bowl diseases. However, existing intestinal cells do not possess all physiologically relevant subtypes, do not possess the repertoire of genetic variations, or allow for study of other important cellular actors such as immune cells. Use of iPSC-derived epithelium, including IBD patient-specific cells, allows for superior disease modeling by capturing the multi-faceted nature of the disease.

Abstract: A larvicide comprising an essential oil encapsulated within a non-viable yeast cell. The larvicide is particularly effective against mosquito larvae, non-toxic to humans and other non-target species, inexpensive to make, and non-toxic during manufacture, transport, and storage.

Abstract: Organs-on-chips are microfluidic devices for culturing living cells in micrometer sized chambers in order to model physiological functions of tissues and organs. Engineered patterning and continuous fluid flow in these devices has allowed culturing of intestinal cells bearing physiologically relevant features and sustained exposure to bacteria while maintaining cellular viability, thereby allowing study of inflammatory bowl diseases. However, existing intestinal cells do not possess all physiologically relevant subtypes, do not possess the repertoire of genetic variations, or allow for study of other important cellular actors such as immune cells. Use of iPSC-derived epithelium, including IBD patient-specific cells, allows for superior disease modeling by capturing the multi-faceted nature of the disease.

Abstract: Induced pluripotent stem cell (iPSC)-based organoid technology has tremendous potential to elucidate the intestinal and colonic epithelium's role in health and disease. Described herein are methods and compositions for generation of intestinal and colonic cells from iPSCs. Derivation of iPSCs from subjected afflicted with early onset and very early onset Inflammatory Bowel Disease (IBD), serves as an excellent model for understanding disease pathogenesis.

Abstract: A larvicide comprising an essential oil encapsulated within a non-viable yeast cell. The larvicide is particularly effective against mosquito larvae, non-toxic to humans and other non-target species, inexpensive to make, and non-toxic during manufacture, transport, and storage.

Abstract: Organs-on-chips are microfluidic devices for culturing living cells in micrometer sized chambers in order to model physiological functions of tissues and organs. Engineered patterning and continuous fluid flow in these devices has allowed culturing of intestinal cells bearing physiologically relevant features and sustained exposure to bacteria while maintaining cellular viability, thereby allowing study of inflammatory bowl diseases. However, existing intestinal cells do not possess all physiologically relevant subtypes, do not possess the repertoire of genetic variations, or allow for study of other important cellular actors such as immune cells. Use of iPSC-derived epithelium, including IBD patient-specific cells, allows for superior disease modeling by capturing the multi-faceted nature of the disease.

Abstract: Organs-on-chips are microfluidic devices for culturing living cells in micrometer sized chambers in order to model physiological functions of tissues and organs. Engineered patterning and continuous fluid flow in these devices has allowed culturing of intestinal cells bearing physiologically relevant features and sustained exposure to bacteria while maintaining cellular viability, thereby allowing study of inflammatory bowl diseases. However, existing intestinal cells do not possess all physiologically relevant subtypes, do not possess the repertoire of genetic variations, or allow for study of other important cellular actors such as immune cells. Use of iPSC-derived epithelium, including IBD patient-specific cells, allows for superior disease modeling by capturing the multi-faceted nature of the disease.

Abstract: A wiring substrate connects an electrical system of a towed vehicle to an electrical system of a towing vehicle and includes a wiring connector configured to connect to a connector from a wiring harness of the towed vehicle, a first set of connections to connect to tail light assemblies in the towed vehicles, a second set of connections to connect to vehicle signal connections in the towed vehicle, the first and second sets of connections electrically coupled on the wiring substrate by at least one diode, and a third set of connections to connect to the towing vehicle.

Abstract: A wiring substrate connects an electrical system of a towed vehicle to an electrical system of a towing vehicle and includes a wiring connector configured to connect to a connector from a wiring harness of the towed vehicle, a first set of connections to connect to tail light assemblies in the towed vehicles, a second set of connections to connect to vehicle signal connections in the towed vehicle, the first and second sets of connections electrically coupled on the wiring substrate by at least one diode, and a third set of connections to connect to the towing vehicle.

Abstract: A wiring substrate connects an electrical system of a towed vehicle to an electrical system of a towing vehicle and includes a wiring connector configured to connect to a connector from a wiring harness of the towed vehicle, a first set of connections to connect to tail light assemblies in the towed vehicles, a second set of connections to connect to vehicle signal connections in the towed vehicle, the first and second sets of connections electrically coupled on the wiring substrate by at least one diode, and a third set of connections to connect to the towing vehicle.

Abstract: A system and method for automatically determining state ranges for data displayed on a display medium is disclosed. At least one metric relating to an object within a problem set is selected. Range parameters used in generating state ranges for each selected metric are specified. The range parameters include the number of state ranges for each metric and at least one statistical model. Data reflecting the values of each selected metric is input and analyzed using the range parameters, resulting in at least one state range for each of the selected metrics and statistical models. The statistical model that provides the best fit to the data is selected. The state ranges for the selected metrics and statistical model are output for use by a display medium that displays data relating to the selected metrics as a graphical representation of a state of the object to which the metric relates.