Abstract: Compositions and methods for diagnosing and treating multiple sclerosis (MS) and other health conditions involve collecting serum samples from a subject and exposing the serum samples to a protein capture composition, collecting the unbound eluent or flow-through, and measuring the levels of at least one immunoglobulin therein. Methods for differentiating between different types of MS also involve exposing serum samples to a protein capture composition and detecting immunoglobulin levels in the flow-through. Based on the detected immunoglobulin levels, an MS subtype is diagnosed in a subject and a treatment regimen can be adjusted or ceased according to the diagnosis.

Abstract: Described are various embodiments of a machine learning system and method for object-specific recognition.

Abstract: Systems and methods for remediating streak in glass ribbons formed from glass forming processes are disclosed. The systems include a laser that produces a stationary laser beam having a wavelength of from about 1 ?m to about 12 ?m and a beam width less than or equal to a full width half maximum of a change in the thickness of the glass ribbon over a streak width at a streak location and optical components to condition and direct the laser beam at the streak location. The methods include forming the glass ribbon, identifying a streak in the glass ribbon, and directing the laser beam at the streak location. The laser beam heats the glass ribbon at the location of the streak, which reduces a viscosity of the glass ribbon to cause glass thinning that reduces the severity of the streak.

Abstract: A method of manufacturing a patient interface for sealed delivery of a flow of air at a continuously positive pressure with respect to ambient air pressure to an entrance to the patient's airways includes collecting anthropometric data of a patient's face. Anticipated considerations are identified from the collected anthropometric data during use of the patient interface. The collected anthropometric data is processed to provide a transformed data set based on the anticipated considerations, the transformed data set corresponding to at least one customised patient interface component. At least one patient interface component is modelled based on the transformed data set.

Abstract: A method includes an operation to collect radar signals reflected from objects in a field of view. A three-dimensional range-angle-velocity cube is formed from the radar signals. The three-dimensional range-angle-velocity cube includes individual bins with radar intensity values characterizing angle and range for a specific velocity. Point-pillar sub-cubes are selected from the three-dimensional range-angle-velocity cube. Each point-pillar sub-cube includes a predefined range surrounding a high energy peak in the range-angle dimensions and an entire range in a velocity vector. The point-pillar sub-cubes are processed to compress, decompress, detect, classify or track objects in the field of view.

Abstract: A transparent structure may have layers with curved cross-sectional profiles. The transparent structure may have inner and outer layers with curved portions formed by bending the layers. A display may be applied to one or more of the inner and outer layers. To reduce the strain applied to the display while being bent into a desired curvature, a carrier film may be used during bending operations. The carrier film may be modified with a patch or openings distribute the strain evenly across the display. Additionally or alternatively, a convex mold may be used to further decrease the strain on the display while being formed into the desired curvature.

Abstract: A device comprising a corneal implant for implantation within the cornea, the implant defining a planar body comprising: (i) an inner platform portion located about an axis of circular symmetry of the implant, (ii) a peripheral portion comprising one or more angularly-spaced arms that extend laterally from a peripheral edge of the inner platform, and (iii) a peripheral skirt portion which defines an outer circular perimeter of the implant, wherein the one or more angularly-spaced arms connect between the inner platform and the peripheral skirt portion; a wireless communication circuit configured for receiving an image data signal from an extraocular unit; an image projection controller configured to process the received image data signal to generate an image; and an image generator mounted to the inner platform portion, configured to project an image projection light beam, based on the generated image, in a posterior direction onto the retina of the eye.

Abstract: The present invention relates to novel spiro-macrocyclic compounds of general formula (I) which are Orexin 2 receptor agonists.

Abstract: Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein. In an embodiment, the splicing modulator comprises a pladienolide or a pladienolide derivative.

Abstract: The disclosed computer-implemented method for multi-lane data bus inversion can include receiving data for transmission via a plurality of data lanes, each data lane corresponding to one of a plurality of inversion bits, and, for each data lane within the plurality of data lanes, applying the corresponding inversion bit to each bit within the data lane. Various other methods, apparatuses, and systems are also disclosed.

Abstract: A frame apparatus, a kit of parts which includes multiple frames and a connector bracket for connecting the frames together, and a method of interconnecting a plurality of frames and hanging the same from a support surface. The frame apparatus may be a front-loading frame whereby display items are inserted into a display cavity of the frame through an opening in the front surface of the frame through which the display cavity is viewed. The frame may include an outer annular wall that defines the display cavity, an inner annular wall that is spaced apart from the outer annular wall, and a floor that extends between the inner and outer annular walls. The floor may comprise a plurality of apertures to allow for attachment of the frame to various accessories including hanging brackets, connector brackets, trays, and the like.

Abstract: An energy system of a building includes a power storage device, and a controller that, during a period of time for which energy costs are lowest, charges a power storage device to a maximum state of charge, and during a period of time for which energy costs are not lowest and an immediate subsequent period of time is predicted to have higher energy costs, charges the power storage device to a target state of charge that is less than the maximum state of charge and that depends on predicted power demand during the subsequent period of time.

Abstract: System, methods, apparatuses, and computer program products are disclosed for auto-scaling of a deployment based on resource utilization data for a workload executing on the deployment. A resource availability is determined based on the resource utilization data and a current resource allocation of the deployment. A severity of resource throttling of the workload may be determined based on the resource utilization data, and a scaling factor is determined based at least on the severity of resource throttling. In response to at least the resource availability satisfying a predetermined condition with a predetermined threshold, the deployment is scaled based on the scaling factor.

Abstract: An example methodology includes provisioning memory of a storage array with cache memory including a plurality of cache slots and reading data from the memory of the storage array into a first cache slot of the plurality of cache slots, wherein the data in the first cache slot is in a first data format, the first data format being the format of data in the memory of the storage array. The method also includes converting the data in the first cache to a second data format distinct from the first data format and placing the data in the second data format into a second cache slot of the plurality of cache slots.

Abstract: Methods, devices and media for two-pass source code transformation from a first high-level programming language to a second high-level programming language are described. Two different source code transformation technologies are combined to produce a two-pass source code transformation method: a compiler-based source code transformation technique is used in a first pass, and a parse-tree-based source code transformation technique is used in second pass. The second pass may be used to automatically refactor the source code to enhance desired properties of the second programming language. A two-pass C-to-Rust transformation technique, CRustS, is described which automatically generates Rust source code that exhibits memory safety and overcomes other limitations of existing tools such as C2Rust.

Abstract: A forecast for compatible advertisement opportunities, compatible with a class of advertisements, that will be available over a future time period is generated. For a content item associated with one or more advertisement opportunities, one or more compatible advertisement opportunities of the one or more advertisement opportunities are determined based on characteristics of the class of advertisements. Expected output of the content item over the future time period may be determined from historical data of output of other content items similar to the content item, and may be adjusted based on additional information, such as actual output of the content item. The forecast may be generated from the compatible advertisement opportunities associated with the content item and the expected output of the content item.

Abstract: The present disclosure provides systems and methods for product handling and dispensing. In one aspect, the present disclosure provides a system comprising a tray comprising one or more lanes and one or more openings disposed on a bottom surface of the tray; one or more supports positioned within at least one of the one or more lanes, wherein the one or more supports are configured to support one or more items; and one or more dispensing units comprising one or more dispensing arms, wherein the one or more dispensing arms are configured to (i) couple to, engage with, or lift the one or more supports and (ii) transport (a) the one or more supports, (b) the one or more items on the one or more supports, or (c) both the one or more supports and the one or more items to one or more receiving areas or receiving units.

Abstract: A modified collagen hybridizing peptide (CHP) may include one or more binding partners crosslinked to a CHIP. The CHP has a sequence represented by Formula (I): (Gly-X-Y)a-b, wherein Gly is glycine, at least one of X and Y is proline, modified proline and/or hydroxy proline, and a is 3 and b is 20. The one or more binding partners is selected from the group consisting of integrin sites, integrin binding sites, crosslinking sites, von Willebrand Factor (VWF) discoidin domain receptor (DDR) 1, DDR 2, SPARC binding peptides, fibronectin binding peptides, engineered integrin binding peptides, matrix metalloproteinase (MMP) cleavage sites. Cathepsin K (CATK) sites, and osteoclast-associated receptors (OSCAR).

Abstract: Described herein are prediction models based on the transcriptomic, exomic, and/or radiological analyses on tissue samples to predict the likelihood of the original cancer (such as Hepatocellular carcinoma (HCC)) recurrence into the liver transplant. An example computer implemented method for predicting the likelihood of liver cancer recurrence 5 into a liver transplant includes receiving gene expression data related to a liver tissue sample for a subject having a liver cancer, inputting the gene expression data into a trained machine learning model, and predicting, using the trained machine learning model, a risk of recurrence of the liver cancer in the subject after liver transplantation.

Abstract: A system and method for segmenting an anatomical structure in ultrasound imaging data. First ultrasound imaging data of a first region, which includes the anatomical structure, is acquired at a high resolution. Second ultrasound imaging data of a second region, which includes a region neighboring the first region, is acquired at a low resolution. The first and second ultrasound imaging data are processed to segment the anatomical structure.