Abstract: The disclosure relates to compounds of Formula (I) as allosteric chromenone inhibitors of phosphoinositide 3-kinase (PI3K) useful in the treatment of diseases or disorders associated with PI3K modulation, Formula (I): or pharmaceutically acceptable salts thereof wherein R, R1, R2, R3, R4, R5, R6, R7, and R8, are as defined herein. The disclosure also relates to methods of making and using compounds of Formula (I) or pharmaceutically acceptable salts thereof.

Abstract: Aspects of the present disclosure involve systems and methods for performing operations comprising providing a messaging application comprising a feature to a client device, the feature being implemented by operations having alternative complexity levels, wherein a first complexity level represents a first amount of device resources consumed by a first set of operations, and wherein a second complexity level represents a second amount of device resources consumed by a second set of operations; determining that the first configuration rule is satisfied by a first property of the client device; and in response to determining that the first configuration rule is satisfied by the first property of the client device, causing the feature to be implemented on the client device by the first set of operations having the first complexity level that consume a greater amount of device resources than the second set of operations having the second complexity level.

Abstract: HIV-1 Env ectodomain trimers stabilized in a prefusion mature closed conformation and methods of their use and production are disclosed. In several embodiments, the HIV-1 Env ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to HIV-1 in a subject. In additional embodiments, the therapeutically effective amount of the HIV-1 Env ectodomain trimers can be administered to a subject in a method of treating or preventing HIV-1 infection.

Abstract: Methods, compositions, and kits for adhering polymers and other materials to another material, and in particular to bone or bone-like structures or surfaces. A composition of matter includes a urethane dimethacrylate-methyl methacrylate copolymer with a plurality of first polymer regions based on urethane dimethacrylate and a plurality of second polymer regions based on methyl methacrylate. The method includes placing an orthopedic joint implant having an attachment surface in a joint space, applying a first non-urethane-containing precursor, a second urethane-containing precursor, and a initiator to the attachment surface; contacting the first and second precursors and the initiator with the joint surface; and copolymerizing the first and second precursors and forming an adhesive copolymer and attaching the implant to the joint.

Abstract: The present application discloses a method, system, and computer system for managing data using keys. The method includes receiving a request to access data, wherein the data is encrypted based on a tenant service encryption key (TSEK) corresponding to the tenant database, determining a wrapper key used in connection with encrypting the TSEK based on a TSEK metadata, determining a top-level key used in connection with encrypting the wrapper key based on wrapper key metadata stored in association with the encrypted version of the wrapper key, obtaining the data stored within the tenant database, comprising decrypting at least part of the data based on (i) the TSEK, (ii) the wrapper key, and (iii) the top-level key, and providing the data in response to the request. The TSEK metadata is stored in the tenant database. An encrypted version of the wrapper key is stored in a key management service.

Abstract: Systems and methods are disclosed for securely executing user-defined functions within a cloud data platform. A method involves receiving, via hardware processors, a request to execute a user-defined function (UDF) contained within a sandbox process. The UDF comprises code for performing specified operations that necessitate access to external resources. To facilitate this access, a secure egress path is established using an overlay network designed to isolate the UDF's network traffic from other processes. Authentication and authorization details for the UDF are managed externally to the sandbox process, ensuring that the UDF's functionality remains orthogonal to the cloud data platform's operations. This approach enables the secure and controlled execution of UDFs, allowing them to interact with external systems while maintaining the integrity and security of the cloud data platform environment.

Abstract: Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein. In an embodiment, the splicing modulator comprises a pladienolide or a pladienolide derivative.

Abstract: A patient interface for sealed delivery of a flow of air at a continuously positive pressure with respect to ambient air pressure to an entrance to the patient's airways including at least entrance of a patient's nares to ameliorate sleep disordered breathing may include a seal-forming structure comprising a foam undercushion and a textile membrane for contact with the patient's face; a positioning and stabilising structure to maintain the seal-forming structure in sealing contact with an area surrounding an entrance to the patient's airways while maintaining a therapeutic pressure at the entrance to the patient's airways; and a plenum chamber pressurised at a pressure above ambient pressure in use.

Abstract: The present disclosure relates to administration speed of obinutuzumab.

Abstract: A fuel cell interconnect includes fuel ribs disposed on a first side of the interconnect and a least partially defining fuel channels, and air ribs disposed on an opposing second side of the interconnect and at least partially defining air channels. The fuel channels include central fuel channels disposed in a central fuel field and peripheral fuel channels disposed in peripheral fuel fields disposed on opposing sides of the central fuel field. The air channels include central air channels disposed in a central air field and peripheral air channels disposed in peripheral air fields disposed on opposing sides of the central air field. At least one of the central fuel channels or the central air channels has at least one of a different cross-sectional area or length than at least one of the respective peripheral fuel channels or the respective peripheral air channels.

Abstract: This disclosure relates to methods for the treatment of neoplastic disorders by administering Compound 1, or a pharmaceutically acceptably salt thereof, on its own and/or as part of a conjugate or composition, and inducing production of at least one neoantigen.

Abstract: The invention concerns method of treating multiple sclerosis (MS) by administering a therapeutically effective dose of LOU064 or a pharmaceutically acceptable salt thereof.

Abstract: A size of an optical aperture for an imaging system is adjustable. The size of the optical aperture can be adjusted based on refractive index matching, optical absorption, or near field coupling techniques. These techniques may also be used to provide a high speed optical shutter.

Abstract: The present invention discloses a method of preparing procollagen from freshwater fish. The method comprises the following steps: pressure treatment, physical crushing, mixing and emulsification, homogenization, refrigeration, cleaning, extraction, homogenization, inactivation, homogenization, and filtration. In the mixing and emulsification step, freshwater fish tissue containing collagen is mixed with a surfactant to remove endotoxins to below 0.25 EU/ml. The procollagen is extracted following the step of adding enzymes and an acid solution of pH 3 to 6 to the pretreated tissue. The pretreatment of freshwater fish tissue in this invention can effectively reduce the endotoxins to below 0.25 EU/ml. The extraction technique of this invention can extract and retain greater amounts of procollagen while increasing its denaturation temperature and preserving the intact, tightly twisted triple-helix bonds of type I procollagen.

Abstract: The present invention relates to an epoxy-resin composition as matrix component for sheet molding compounds (SMC) and/or bulk molding compounds (BMC), comprising a resin component comprising at least one epoxy resin and a hardener component comprising at least one aminoalkylimidazole compound, at least one diazabicycloalkylen compound and at least one latent hardener. In said epoxy-resin composition, the amount of the aminoalkylimidazole compounds used is in the range from 0.007 to 0.025 mol per mole of epoxy groups of the entire composition. The invention also relates to a fiber-matrix-semifinished-product composition (SMC composition or BMC composition) with, as matrix component, the epoxy-resin composition mentioned, and with, suspended therein, short reinforcement fibers with an average length of from 0.3 to 5.0 cm.

Abstract: A light control film includes opposing substantially planar substantially parallel first and second major surfaces spaced apart along a thickness direction of the light control film by less than about 500 microns; and a plurality of substantially parallel optically transparent polymeric columns disposed in, and substantially surrounded by, a light absorbing polymeric material. Each of the polymeric columns has a first column end at the first major surface and an opposite second column end at the second major surface and has an aspect ratio of greater than about 3, such that the first column ends of at least one pair of adjacent polymeric columns include substantially parallel substantially straight sides facing, and substantially coextensive with, each other.

Abstract: Systems, devices, media, and methods are presented for assigning configuration parameters to unknown devices by comparing characteristics of unknown devices to characteristics of known devices. Characteristics of an unknown device are compared to characteristics of known devices to identify a similar device having known configuration parameters. The unknown device is then assigned the configuration parameters of the identified similar device.

Abstract: An electrochemical cell stack includes electrochemical cells that each contain a fuel electrode, an air electrode and an electrolyte disposed therebetween, interconnects disposed between the electrochemical cells, and an interconnect end plate disposed over the fuel electrode of an outermost one of the electrochemical cells. The interconnect end plate includes a fuel side, an opposing air side, fuel ribs disposed on the fuel side and at least partially defining fuel channels, air ribs disposed on the air side and at least partially defining dummy air channels, fuel holes extending from the fuel side to the air side, and recessed ring seal regions disposed on the air side surrounding the fuel holes.

Abstract: The present disclosure involves, systems, software, and computer-implemented methods for determining a location for a curbside branch. One example system comprises a memory storing instructions; at least one hardware processor interoperably coupled with the memory, wherein the instructions instruct the at least one hardware processor to: obtain historical and current exchange data of users associated with a particular location; obtain external data about the particular location; enrich the historical and current exchange data with the external data; identify one or more analysis rules to apply to the enriched data to determine an estimated demand for services associated with deployment of a mobile site at the particular location; compare estimated demand to a predetermined threshold; and in response to a determination that the estimated demand exceeds the predetermined threshold, identify the particular location for mobile site deployment.

Abstract: Disclosed are example embodiments of a power system. The power system includes a half-bridge circuit. The half-bridge circuit includes a voltage input and at least one voltage output. The power system also includes an isolation interface, coupled to the half-bridge circuit. The power system includes control circuitry, coupled to the half-bridge circuit through the isolation interface, wherein the half-bridge circuit is configurable, and wherein the voltage input and the at least one voltage output of the half-bridge circuit are isolated from the control circuitry by the isolation interface.