Abstract: The invention relates to a process for preparing bromine-containing polymer, comprising a Friedel-Crafts alkylation reaction of tetrabromoxylylene dihalide, or tetrabromoxylylene dihalide in combination with pentabromobenzyl halide, with a reactant having one or more six-membered aromatic rings, wherein the reaction takes place in a solvent in the presence of a Friedel-Crafts catalyst, and isolating from the reaction mixture the bromine-containing polymer. The so-formed polymers and their use as flame retardants form additional aspects of the invention.

Abstract: The invention relates to a process for preparing bromine-containing polymer, comprising a Friedel-Crafts alkylation reaction of tetrabromoxylylene dihalide, or tetrabromoxylylene dihalide in combination with pentabromobenzyl halide, with a reactant having one or more six-membered aromatic rings, wherein the reaction takes place in a solvent in the presence of a Friedel-Crafts catalyst, and isolating from the reaction mixture the bromine-containing polymer. The so-formed polymers and their use as flame retardants form additional aspects of the invention.

Abstract: The invention relates to a process for preparing bromine-containing polymer, comprising a Friedel-Crafts alkylation reaction of tetrabromoxylylene dihalide, or tetrabromoxylylene dihalide in combination with pentabromobenzyl halide, with a reactant having one or more six-membered aromatic rings, wherein the reaction takes place in a solvent in the presence of a Friedel-Crafts catalyst, and isolating from the reaction mixture the bromine-containing polymer. The so-formed polymers and their use as flame retardants form additional aspects of the invention.

Abstract: The invention provides a process for preparing bromine-containing polymers, comprising a Friedel-Crafts alkylation reaction of pentabromobenzyl halide with a polymer reactant which contains one or more six-membered aromatic ring(s) in its repeat unit, in the presence of at least one Friedel-Crafts catalyst. The so-formed bromine-containing polymers, having pendent —CH2C6Br5 groups attached to at least a portion of the six-membered aromatic rings of the polymer, with a carbon ring atom of said six-membered aromatic ring being bonded to the aliphatic carbon of said —CH2C6Br5 pendent group, are also provided. These bromine-containing polymers are useful as flame retarding agents.

Abstract: The invention provides a process for preparing bromine-containing polymers, comprising a Friedel-Crafts alkylation reaction of pentabromobenzyl halide with a polymer reactant which contains one or more six-membered aromatic ring(s) in its repeat unit, in the presence of at least one Friedel-Crafts catalyst. The so-formed bromine-containing polymers, having pendent —CH2C6Br5 groups attached to at least a portion of the six-membered aromatic rings of the polymer, with a carbon ring atom of said six-membered aromatic ring being bonded to the aliphatic carbon of said —CH2C6Br5 pendent group, are also provided. These bromine-containing polymers are useful as flame retarding agents.

Abstract: The invention relates to a process for preparing bromine-containing polymer, comprising a Friedel-Crafts alkylation reaction of tetrabromoxylylene dihalide, or tetrabromoxylylene dihalide in combination with pentabromobenzyl halide, with a reactant having one or more six-membered aromatic rings, wherein the reaction takes place in a solvent in the presence of a Friedel-Crafts catalyst, and isolating from the reaction mixture the bromine-containing polymer. The so-formed polymers and their use as flame retardants form additional aspects of the invention.

Abstract: The invention provides a process for preparing bromine-containing polymers, comprising a Friedel-Crafts alkylation reaction of pentabromobenzyl halide with a polymer reactant which contains one or more six-membered aromatic ring(s) in its repeat unit, in the presence of at least one Friedel-Crafts catalyst. The so-formed bromine-containing polymers, having pendent —CH2C6Br5 groups attached to at least a portion of the six-membered aromatic rings of the polymer, with a carbon ring atom of said six-membered aromatic ring being bonded to the aliphatic carbon of said —CH2C6Br5 pendent group, are also provided. These bromine-containing polymers are useful as flame retarding agents.

Abstract: The invention provides pentabromobenzyl moiety containing hydroxy-functional compounds which are useful as flame-retardants in flexible and rigid polyurethane foams and also in rigid polyisocyanurate foams. Processes for preparing the compounds, polyurethane and polyisocyanurate foams containing the compounds are also provided by the invention.

Abstract: An application may provide a communication session platform for a first participant to communicate to a second recipient in a service provider capacity. For instance a doctor, lawyer or other service provider may initiate a call application on a their user device and the device may transmit a communication session request to another user device of a patient or client, via the call application. The application may also provide transmitting a consent request to the client user device requesting consent to a term described by a pre-recorded content segment and receiving a confirmation message from the client user device agreeing to the consent request, and bridging the communication session between the client user device and the service provide user device.

Abstract: The invention provides pentabromobenzyl moiety containing hydroxy-functional compounds which are useful as flame-retardants in flexible and rigid polyurethane foams and also in rigid polyisocyanurate foams. Processes for preparing the compounds, polyurethane and polyisocyanurate foams containing the compounds are also provided by the invention.

Abstract: An application may provide a communication session platform for a first participant to communicate to a second recipient in a service provider capacity. For instance a doctor, lawyer or other service provider may initiate a call application on a their user device and the device may transmit a communication session request to another user device of a patient or client, via the call application. The application may also provide transmitting a consent request to the client user device requesting consent to a term described by a pre-recorded content segment and receiving a confirmation message from the client user device agreeing to the consent request, and bridging the communication session between the client user device and the service provide user device.

Abstract: Provided are novel polymorphs and pseudopolymorphs of valacyclovir hydrochloride and pharmaceutical compositions containing these. Also provided are methods for making the novel polymorphs and pseudopolymorphs, which include valacyclovir hydrochloride monohydrate and valacyclovir hydrochloride dihydrate.

Abstract: The present invention relates to protected valacyclovir, N-tert-butoxycarbonyl-L-valine 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy] ethyl ester, and a method of making it. The present invention further relates to a method of making valacyclovir including the steps of coupling an amine protected valine selected from N-t-butoxycarbonyl valine and N-formyl valine with acyclovir using a coupling agent to form a protected valacyclovir, and deprotecting the protected valacyclovir to form valacyclovir or a pharmaceutically acceptable salt thereof. The present invention further relates to valacyclovir in pure form, a method of making pure valacyclovir, and to compositions containing pure valacyclovir.

Abstract: Provided are novel crystalline forms of valacyclovir hydrochloride, in particular a novel hydrated form of valacyclovir hydrochloride having about 6% to about 10% by weight water. Also provided are methods for making the novel crystalline forms.

Abstract: The present invention relates to protected valacyclovir, N-tert-butoxycarbonyl-L-valine 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy] ethyl ester, and a method of making it. The present invention further relates to a method of making valacyclovir including the steps of coupling an amine protected valine selected from N-t-butoxycarbonyl valine and N-formyl valine with acyclovir using a coupling agent to form a protected valacyclovir, and deprotecting the protected valacyclovir to form valacyclovir or a pharmaceutically acceptable salt thereof. The present invention further relates to valacyclovir in pure form, a method of making pure valacyclovir, and to compositions containing pure valacyclovir.

Abstract: Provided are novel polymorphs and pseudopolymorphs of valacyclovir hydrochloride and pharmaceutical compositions containing these. Also provided are methods for making the novel polymorphs and pseudopolymorphs, which include valacyclovir hydrochloride monohydrate and valacyclovir hydrochloride dihydrate.

Abstract: The present invention relates to protected valacyclovir, N-tert-butoxycarbonyl-L-valine 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy] ethyl ester, and a method of making it. The present invention further relates to a method of making valacyclovir including the steps of coupling an amine protected valine selected from N-t-butoxycarbonyl valine and N-formyl valine with acyclovir using a coupling agent to form a protected valacyclovir, and deprotecting the protected valacyclovir to form valacyclovir or a pharmaceutically acceptable salt thereof. The present invention further relates to valacyclovir in pure form, a method of making pure valacyclovir, and to compositions containing pure valacyclovir.

Abstract: Provided are novel polymorphs and pseudopolymorphs of valacyclovir hydrochloride and pharmaceutical compositions containing these. Also provided are methods for making the novel polymorphs and pseudopolymorphs, which include valacyclovir hydrochloride monohydrate and valacyclovir hydrochloride dihydrate.