Abstract: Provided herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof, useful as RIPK1 inhibitors, and pharmaceutical compositions comprising same. Further provided are methods of use and preparation. Also provided are methods of treating Ulcerative Colitis using a compound of Formula (I).

Abstract: Provided herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof, useful as RIPK1 inhibitors, and pharmaceutical compositions comprising same. Further provided are methods of use and preparation. Also provided are methods of treating Ulcerative Colitis using a compound of Formula (I).

Abstract: A modular wound treatment system includes a central modular hub having a modular connection for one or more pneumatically-actuated, modular components, such as a pneumatically-actuated soft robotic gripper component configured to curve and at least partially encircle the wound when actuated and thereby apply direct pressure to the wound, and a pneumatically-actuated tourniquet component configured to apply pressure proximal to the wound to limit the flow of arterial blood to the wound. The system also includes a pressurized gas supply in pneumatic communication with the modular connection, sensors for measuring the amount of pressure being applied by the pneumatically-actuated, modular components, a display for providing system information, and a controller for controlling the system. Methods of treating a wounded subject using the system are also provided.

Abstract: A modular wound treatment system includes a central modular hub having a modular connection for one or more pneumatically-actuated, modular components, such as a pneumatically-actuated soft robotic gripper component configured to curve and at least partially encircle the wound when actuated and thereby apply direct pressure to the wound, and a pneumatically-actuated tourniquet component configured to apply pressure proximal to the wound to limit the flow of arterial blood to the wound. The system also includes a pressurized gas supply in pneumatic communication with the modular connection, sensors for measuring the amount of pressure being applied by the pneumatically-actuated, modular components, a display for providing system information, and a controller for controlling the system. Methods of treating a wounded subject using the system are also provided.

Abstract: The invention relates to an activation apparatus (20) for a galvanically decoupled direct voltage converter having a synchronous rectifier, comprising a signal generating device (22), which is designed to generate control signals (22c, 22d) for switch devices of the synchronous rectifier and a reference current signal (22b), a first comparator device (23), which is coupled to the signal generating device (22), and which is designed to detect the secondary-side output current (Jo) of the synchronous rectifier, compare it to the reference current signal (22b) and generate a current control signal in dependence on the comparison, and a pulse width modulation device (25), which is coupled to the signal generating device (22) and the first comparator device (23) and which is designed to generate pulse width modulated activation signals (25a) for the switch devices of the synchronous rectifier on the basis of the control signals (22c, 22d) and the current control signal, wherein the signal generating device (22) is

Abstract: The invention relates to an activation apparatus (20) for a galvanically decoupled direct voltage converter having a synchronous rectifier, comprising a signal generating device (22), which is designed to generate control signals (22c, 22d) for switch devices of the synchronous rectifier and a reference current signal (22b), a first comparator device (23), which is coupled to the signal generating device (22), and which is designed to detect the secondary-side output current (Jo) of the synchronous rectifier, compare it to the reference current signal (22b) and generate a current control signal in dependence on the comparison, and a pulse width modulation device (25), which is coupled to the signal generating device (22) and the first comparator device (23) and which is designed to generate pulse width modulated activation signals (25a) for the switch devices of the synchronous rectifier on the basis of the control signals (22c, 22d) and the current control signal, wherein the signal generating device (22) is

Abstract: A method for adjusting a loudness of an announcement sound signal relative to a loudness of an entertainment sound signal, the method including the steps of determining the loudness of the entertainment sound signal, and adjusting the loudness of the announcement sound signal relative to the entertainment sound signal by determining a self-adaptive gain offset of the announcement sound signal relative to the entertainment sound signal, the self-adaptive gain offset adapting to the auditory perception of a user to which the entertainment sound signal and the announcement sound signal are output.

Abstract: A method for adjusting a loudness of an announcement sound signal relative to a loudness of an entertainment sound signal, the method including the steps of determining the loudness of the entertainment sound signal, and adjusting the loudness of the announcement sound signal relative to the entertainment sound signal by determining a self-adaptive gain offset of the announcement sound signal relative to the entertainment sound signal, the self-adaptive gain offset adapting to the auditory perception of a user to which the entertainment sound signal and the announcement sound signal are output.

Abstract: A method and system for determining the position of a sound source in relation to a reference position, comprising the steps of generating a sound signal emitted from the sound source, detecting the emitted sound signal, processing the sound signal by the use of a physiological model of the ear, deducing at least one of lateral deviation in relation to the reference position, time delay of the sound signal from the sound source to the reference position, and the sound level of the detected sound signal.

Abstract: A system for processing credit applications. An adaptive decision engine produces a score determined by the risk associated with a credit application. The credit application is automatically approved or rejected if the score is above or below certain thresholds, and is otherwise referred for manual processing. The system may include a rules system that automatically approves applications if all conditions are met, and generates exceptions if all conditions are not met and refers the application to the adaptive decision engine for further processing. A decision to approve or reject an application may be based on a combination of the risk score and number of exceptions.

Abstract: A method and system for determining the position of a sound source in relation to a reference position, comprising the steps of generating a sound signal emitted from the sound source, detecting the emitted sound signal, processing the sound signal by the use of a physiological model of the ear, deducing at least one of lateral deviation in relation to the reference position, time delay of the sound signal from the sound source to the reference position, and the sound level of the detected sound signal.

Abstract: An audio decoding device for decompressing an audio signal that was compressed in accordance with a given compression method having a program-controlled signal processor which receives the compressed audio signal and from it produces a decompressed audio signal under the control of a decompression program; a loadable program memory that is connected to the signal processor for storing the decompression program; and a management device which is connected to the program memory and is controlled by the compressed audio signal, and which manages decompression programs corresponding to at least two different compression methods in order to determine the respectively used compression method from the compressed audio signal, to select the pertinent decompression program and to load the pertinent decompression program into the program memory.