Abstract: Presented are advanced control systems providing tire change modes for vehicles with adjustable ride-height suspension systems, methods for making/using such systems, and vehicles equipped with such systems. A method of operating a vehicle includes a controller receiving an input signal indicative of a tire change event for the vehicle, and determining a location of a tire associated with the tire change event. In response to receiving the input signal, the controller determines if a real-time slope of the vehicle is greater than a preset maximum secure slope; if not, the controller prompts a user to prepare the vehicle for the tire change event. After prompting the user to prep the vehicle, the controller commands the vehicle's ride height suspension system to lower the ride height of the tire's corner module to a predefined lowered height and raise the ride height of all other corner module to a predefined raised height.

Abstract: A power tool having a tool and a motor, with the motor of the power tool being operated in a speed range from 2,000 to 30,000 rpm and with an inertia of the motor lying in a range from 20·10?6 to 750·10?6 kg·m2. In a second aspect, the invention relates to a method for operating a power tool which is operated in a speed range from 2,000 to 30,000 rpm, with an inertia of the motor lying in a range from 20·10?6 to 750·10?6 kg·m2. By selecting and specifying a set of parameters which describe characteristics of the motor of the power tool, the power tool can be designed and operated in such a way that a mechanical slip clutch can be dispensed with. The motor parameters “speed” and “inertia” are selected in particular so that a maximum torque in a transmission of the power tool is always below a specified upper limit.

Abstract: A control system includes a task manager that can determine capability requirements to perform a task on the target object. The task has an associated series of sub-tasks, with the sub-tasks having one or more capability requirements. The task manager selects and assigns a first sequence of sub-tasks to a first robotic machine that has a first set of capabilities and operates according to a first mode of operation. The task manager selects and assigns a second sequence of sub-tasks to a second robotic machine that has a second set of capabilities and operates according to a second mode of operation. The task manager selects the first robotic machine based on the first set of capabilities and the first mode of operation of the first robotic machine, and selects the second robotic machine based on the second set of capabilities and the second mode of operation.

Abstract: Polyoxazoline (POZ) conjugates wherein the conformation of the POZ conjugate and the release rate of an agent from the POZ conjugate can be controlled by selecting one or more characteristics of the POZ polymer and methods of controlling the conformation of a POZ conjugate and the release rate of an agent prior are provided as well as methods of treatment using such POZ conjugates and methods. Pharmaceutical compositions including a POZ conjugate are also provided.

Abstract: A modified p145 peptide having enhanced mucosal immunogenicity for use in eliciting a mucosal immune response to group A streptococcal bacteria in a mammal such as a human. Intramuscular administration of the modified p145 peptide may be particularly efficacious. An S2 peptide or variant may be co-administered with the modified p145 peptide to enhance the immune response.

Abstract: In some aspects, the described systems and methods provide for a method for training a deep learning model to assess liver pathology, including accessing annotated liver pathology images associated with a group of patients in one or more randomized controlled clinical trials of nonalcoholic steatohepatitis therapy, each of the annotated liver pathology images including at least one annotation describing one or more tissue characteristic categories for a portion of the image, and training the deep learning model based on the annotated liver pathology images to predict the tissue characteristic categories, selected from a group comprising steatosis, lobular inflammation, hepatocyte ballooning, and fibrosis stage.

Abstract: Embodiments of a catheter assembly are disclosed. The catheter assembly comprises a shaft; a connector assembly comprising a first connector portion and a second connector portion, wherein the first connector portion is fixedly coupled to a distal end of the shaft, and is rotatably coupled to the second connector portion by at least one radially extending pin retained within at least one slot on the second connector portion, wherein the at least one slot has an oversized circumferential dimension that allows limited rotation of the second connector portion relative to the first connector portion about a longitudinal axis of the shaft.

Abstract: A product for mitigating the ill-effects of post-coital discharge, post-medical-procedure discharge, and post-urination discharge in men. A sleeve-like pouch includes an inside and an outside, with a top layer disposed on the inside of the sleeve-like pouch, and a bottom layer disposed on the outside of the sleeve-like pouch. An absorbent layer is disposed between the top layer and bottom layer. The sleeve-like pouch is configured to be slid onto and securely surround a male appendage.

Abstract: A seeding machine (32,100) includes a seeding mechanism (34,130,150) driven by a seeding motor (194,196). A motor command signal is compensated for accelerations based on a wheel based speed of a towing vehicle (10).

Abstract: A gas turbine engine according to an example of the present disclosure includes a propulsor section including a propulsor supported on a propulsor shaft, a turbine section including a turbine shaft, a compressor section having a plurality of compressor hubs with blades driven by the turbine shaft about an engine axis, and an epicyclic gear train interconnecting the propulsor shaft and the turbine shaft. The epicyclic gear train includes a sun gear coupled to the turbine shaft, intermediary gears arranged circumferentially about and meshing with the sun gear, a carrier and a ring gear including first and second portions. The first and second portions have axially opposed faces abutting one another at a radial interface.

Abstract: A gas turbine engine has a fan drive turbine driving a gear reduction, the gear reduction, in turn, driving a fan rotor, the fan rotor delivering air into a bypass duct as bypass air and into a compressor section as core flow. A forward bearing is positioned between the gear reduction and the fan rotor and supports the gear reduction. A second bearing is positioned aft of the gear reduction and supports the gear reduction. The second bearing is a thrust bearing. A fan drive turbine drive shaft drives the gear reduction. The fan drive turbine drive shaft has a weakened link which is aft of the second bearing such that the fan drive turbine drive shaft will tend to fail at the weakened link, and at a location aft of the second bearing.

Abstract: Methods and microorganisms for improved malonyl-CoA flux and production of products having malonyl-CoA as a precursor. The methods comprise dynamically regulating, in a stationary phase of a method, a nitrogen regulatory protein. The methods may dynamically regulate more than one gene.

Abstract: The present disclosure provides nucleases and compositions, methods, and systems thereof for nucleic acid modification. More particularly, the present disclosure provides compositions and system comprising a nuclease comprising an amino acid sequence having at least 70% identity to any of SEQ ID NOs: 1-1096 and at least one gRNA.

Abstract: A pump support device that is configured to provide support for a centrifugal pump during service so as to facilitate desired orientation and positioning thereof. The present invention includes a base member that is planar in manner having an upper surface and a lower surface. The upper surface of the base member includes a first vertical support member assembly comprised of a plurality of configurable support members. A rotational member is operably coupled to the lower surface of the base member and is configured to provide rotation thereof three-hundred and sixty degrees. A second vertical support member is present on the upper surface and is intermediate the first lateral member and second lateral member of the lateral support assembly. An oil drain member is secured to the upper surface and is operable to direct oil to a container secured to the second end thereof.

Abstract: An extractor apparatus includes a suction opening, a fan arranged under the suction opening for sucking away primary air downward via the suction opening, and an expulsion opening which is adjacent to the suction opening and via which an oriented secondary air stream is expelled.

Abstract: A process for producing a polyol block copolymer in a multiple reactor system including a first and second reactor in which a first reaction takes place in the first reactor and a second reaction takes place in the second reactor. The first reaction is the reaction of a carbonate catalyst with CO2 and epoxide, in the presence of starter and/or solvent to produce polycarbonate polyol copolymer and the second reaction is the reaction of DMC catalyst with the polycarbonate polyol compound of the first reaction and epoxide to produce polyol block copolymer. The product of the first reaction is fed into the second as crude reaction mixture, the epoxide and the polycarbonate polyol compound of the first reaction are fed in a continuous or semi-batch manner, and/or the product of the first reaction has neutral or alkaline pH on addition to the second. The invention further relates to the copolymers and products incorporating such copolymers.

Abstract: Polyoxazoline (POZ) conjugates wherein the conformation of the POZ conjugate and the release rate of an agent from the POZ conjugate can be controlled by selecting one or more characteristics of the POZ polymer and methods of controlling the conformation of a POZ conjugate and the release rate of an agent prior are provided as well as methods of treatment using such POZ conjugates and methods. Pharmaceutical compositions including a POZ conjugate are also provided.

Abstract: High strength biomedical materials and processes for making the same are disclosed. Included in the disclosure are nanoporous hydrophilic solids that can be extruded with a high aspect ratio to make high strength medical catheters and other devices with lubricious and biocompatible surfaces.

Abstract: Systems and methods for the quantification of the quality of an acquired signal are provided for assessment and for gating the acquired signal for subsequent analysis. A signal is acquired, and a determination is made in real-time if there is a problem with the acquisition. If there is a problem, output is provided via the systems and methods described herein to indicate that signal acquisition needs to be performed again.