Patents by Inventor Michaela KÜGLER

Michaela KÜGLER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for generating antibodies against T cell receptor
    Patent number: 11292838
    Abstract: The invention relates to a method for generating an antibody binding to a cell surface protein of interest, the method comprising the following steps: (a) providing a non-human cell which does not express the endogenous form of the cell surface protein of interest but expresses an exogenous form of the cell surface protein of interest comprising at least one human segment; (b) immunization of a non-human animal with the cell line provided in step (a); (c) generation of hybridomas from the immunized non-human animal of step (b); (d) screening for an antibody that binds to the cell surface protein of interest by contacting the antibodies secreted by the hybridomas of step (c) with human cells which do not express the endogenous form of the cell surface protein of interest but express an exogenous form of the cell surface protein of interest comprising at least one human segment.
    Type: Grant
    Filed: June 1, 2016
    Date of Patent: April 5, 2022
    Assignee: MEDIGENE IMMUNOTHERAPIES GMBH
    Inventors: Dolores Schendel, Slavoljub Milosevic, Tanja Herrmann, Michaela Kügler
  • T-CELL RECEPTOR SPECIFIC ANTIBODIES
    Publication number: 20180256716
    Abstract: The present invention relates to an antibody or binding fragment thereof that binds to a fraction of T cell receptor variable alpha (TCR V?) chains comprising at least two different TCR V? chains but less than all TCR V? chains or that binds to a fraction of T cell receptor variable beta (TCR V?) chains comprising at least two different TCR V? chains but less than all TCR V? chains.
    Type: Application
    Filed: June 1, 2016
    Publication date: September 13, 2018
    Inventors: Dolores SCHENDEL, Slavoljub MILOSEVIC, Tanja HERRMANN, Michaela KÜGLER
  • METHOD FOR GENERATING ANTIBODIES AGAINST T CELL RECEPTOR
    Publication number: 20180237520
    Abstract: The invention relates to a method for generating an antibody binding to a cell surface protein of interest, the method comprising the following steps: (a) providing a non-human cell which does not express the endogenous form of the cell surface protein of interest but expresses an exogenous form of the cell surface protein of interest comprising at least one human segment; (b) immunization of a non-human animal with the cell line provided in step (a); (c) generation of hybridomas from the immunized non-human animal of step (b); (d) screening for an antibody that binds to the cell surface protein of interest by contacting the antibodies secreted by the hybridomas of step (c) with human cells which do not express the endogenous form of the cell surface protein of interest but express an exogenous form of the cell surface protein of interest comprising at least one human segment.
    Type: Application
    Filed: June 1, 2016
    Publication date: August 23, 2018
    Inventors: Dolores SCHENDEL, Slavoljub MILOSEVIC, Tanja HERRMANN, Michaela KÜGLER