Patents by Inventor Michaela Niemöller

Michaela Niemöller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Reagents for detection of chimeric antigen receptor cells
    Patent number: 12181475
    Abstract: The invention is directed to a method for preparing a detection reagent for CAR expressing cells according to general formula (I) (X-S)m-D??(I) wherein D is a detection moiety, S a spacer unit and X a polypeptide comprising 10 to 80 amino acids and a N3 group, which binds to the antigen binding domain of a chimeric antigen receptor of a cell and m=4-200, characterized in reacting p detection moieties D with a spacer S according to general formula (II) wherein R is a leaving group, q=1 to 5, and n=4 to 200 and p is 4-250 thereby forming modified detection moiety Sp-D and reacting the modified detection moiety Sp-D with a plurality of polypeptides X to yield (X-S)m-D.
    Type: Grant
    Filed: April 9, 2021
    Date of Patent: December 31, 2024
    Assignee: Miltenyi Biotec B.V. &Co.KG
    Inventors: Michaela Niemöller, Jonathan Fauerbach, Christian Dose, Anne Richter, Tina Borke
  • REAGENTS FOR DETECTION OF CHIMERIC ANTIGEN RECEPTOR CELLS
    Publication number: 20210373017
    Abstract: The invention is directed to a method for preparing a detection reagent for CAR expressing cells according to general formula (I) (X-S)m-D ??(I) wherein D is a detection moiety, S a spacer unit and X a polypeptide comprising 10 to 80 amino acids and a N3 group, which binds to the antigen binding domain of a chimeric antigen receptor of a cell and m=4-200, characterized in reacting p detection moieties D with a spacer S according to general formula (II) wherein R is a leaving group, q=1 to 5, and n=4 to 200 and p is 4-250 thereby forming modified detection moiety Sp-D and reacting the modified detection moiety Sp-D with a plurality of polypeptides X to yield (X-S)m-D.
    Type: Application
    Filed: April 9, 2021
    Publication date: December 2, 2021
    Applicant: Miltenyi Biotec B.V. & Co. KG
    Inventors: Michaela Niemöller, Jonathan Fauerbach, Christian Dose, Anne Richter, Tina Borke