Patents by Inventor Michaela R. Hoffmeyer

Michaela R. Hoffmeyer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods, Particles, and Kits for Determining Activity of a Kinase
    Publication number: 20100317544
    Abstract: Methods, particles and kits for determining kinase activity within a sample are provided. An embodiment of a method includes exposing a fluorescent particle to an assay, wherein the fluorescent particle includes a support substrate having one or more fluorescent materials and a peptide substrate coupled to the support substrate via a functional group of the support substrate. The method further includes phosphorylating the peptide substrate during exposure of the fluorescent particle to the assay and processing the fluorescent particle such that the peptide substrate is dephosphorylated and a polarized double bond is generated at a dephosphorylated site. In addition, the method includes coupling a fluorescent reporter having a nucleophilic terminal group to the fluorescent particle via the polarized double bond.
    Type: Application
    Filed: August 23, 2010
    Publication date: December 16, 2010
    Applicant: LUMINEX CORPORATION
    Inventors: James W. Jacobson, Ananda G. Lugade, Michaela R. Hoffmeyer
  • Methods, particles, and kits for determining activity of a kinase
    Patent number: 7795040
    Abstract: Methods, particles and kits for determining kinase activity within a sample are provided. An embodiment of a method includes exposing a fluorescent particle to an assay, wherein the fluorescent particle includes a support substrate having one or more fluorescent materials and a peptide substrate coupled to the support substrate via a functional group of the support substrate. The method further includes phosphorylating the peptide substrate during exposure of the fluorescent particle to the assay and processing the fluorescent particle such that the peptide substrate is dephosphorylated and a polarized double bond is generated at a dephosphorylated site. In addition, the method includes coupling a fluorescent reporter having a nucleophilic terminal group to the fluorescent particle via the polarized double bond.
    Type: Grant
    Filed: April 17, 2007
    Date of Patent: September 14, 2010
    Assignee: Luminex Corporation
    Inventors: James W. Jacobson, Ananda G. Lugade, Michaela R. Hoffmeyer