Abstract: The invention relates to a method for purifying and enriching a target product selected from immunoglobulins or other proteins; or plasmid DNA, genomic DNA, RNA or other nucleic acids or viruses, wherein the measured electrical conductivity values and/or the measured turbidity values of the phases are used for adjusting the position of the phases in a separating device (10, 100) and for separating the phases. The invention also relates to a device for carrying out the method and to the use thereof.

Abstract: Process for making a modified granule or powder comprising an alkali metal salt of an aminocarboxylate complexing agent (A), said process comprising the steps of (a) providing a granule or powder comprising an alkali metal salt of an aminocarboxylate complexing agent (A), (b) treating said granule or powder with the respective aminocarboxylate complexing agent (A) in which at least one amino group or carboxyl group per molecule is present in the acid form, in the presence or absence of water, (c) performing a heat treatment at a temperature in the range of from 80 to 150° C.

Abstract: Gearbox (1) having a tooth carrier (40) for receiving teeth (7) of a gear ring that are disposed about a rotation axis (5) of the gearbox, wherein the teeth (7) are disposed in the tooth carrier (11) so as to be displaceable and guided in the radial direction, a cam disk (20) which is rotatable about the rotation axis (5) and for driving the teeth (7) in the radial direction has a cam curvature that is variable over the circumference, wherein bearing segments (24) which are mounted so as to slide on the cam disk (20) are disposed between the teeth (7) and the cam disk (20), and wherein the bearing segments (24) have a contact region which has a concave curvature and is disposed so as to be centric on a running surface that faces the cam disk (20), wherein the concave curvature is larger than the smallest cam curvature of the cam disk, and smaller than the largest cam curvature of the cam disk.

Abstract: Surgical anchor constructs, fixation devices, and methods of manufacturing, as well as methods for tissue repairs are disclosed. A soft suture anchor has a sheath with varying densities along the length of the sheath. The anchor sheath can have different segments with different densities which can be provided in a pattern or a random manner. The segments with different densities allow secure fixation of the soft anchor within bone, and attachment of first tissue to second tissue.

Abstract: An orthopedic instrument system that includes a burr and a burr guide. The burr guide includes an elongated opening, in which at least a portion of the elongated opening includes a substantially circular opening having a greater dimension than that of the adjacent portion of the elongated opening. The circular opening is configured to receive at least a portion of the burr therein and therethrough such that the burr may be manipulated along the length of the elongated opening. The burr has a shaft and a first end opposite a second end with the first end being configured to facilitate being releasably coupled to a tool. The second end of the burr has an engagement feature that is configured to cut and/or resurface a bone surface. A method of using the orthopedic instrument system is also disclosed herein.

Abstract: A vaporizer cartridge for an inhaler has a hollow body with a continuous flow channel and liquid storage tank. The tank has an access opening to the channel and a vaporizer unit extending over the entire access opening. The vaporizer unit has a wick member and a heating member. The vaporizer unit is liquid-permeable such that liquid is conveyed at least initially in a capillary manner from the storage tank through the vaporizer unit in the direction of the flow channel. The wick member is formed from a plurality of granular grains which, as a result of their fill and/or formation, form microchannels which establish a fluid connection between the storage tank and the flow channel, continuously from an entry side to an exit side of the wick member. An additional securing means is provided which is holds the granular wick member in position. A corresponding inhaler is also provided.

Abstract: The invention relates to an image-capturing device for the miniaturized near-field image capture of biological tissue, in particular for the imaging of genetic indicators. The image-capturing device comprises at least one digital image sensor and an objective lens in the form of a rod-shaped gradient index lens (GRIN), which objective lens is coupled to the digital image sensor for image capture. The objective lens is connected to the digital image sensor to from a monolithic, fixed assembly. There is no mechanical separating interface between the objective lens and the digital image sensor by means of which the digital image sensor can be separated from the objective lens by the user. The invention further relates to a system for the miniaturized near-field image capture of biological tissue, said system comprising an image-capturing device of this type and an evaluation device connected to the image-capturing device.

Abstract: An example method can comprise receiving content for presentation at a user device. The content can comprise a plurality of sections, and each section can comprise a video portion and an audio portion. The user device can also receive content metadata regarding one or more features of the content, where the features of the content comprise one or more candidate sections of the content for modification. The user device can apply one or more rules to the received content based on the content metadata to modify one or more of the audio portion and the video portion of at least one section of the content, creating modified content, and can cause presentation of the modified content on a display device.

Abstract: A brachytherapy implant including a hollow biocompatible wire, and at least one tubular seed defining an internal channel. Radioactive particles for radiotherapy treatment are placed on the at least one tubular seed. The tubular seed is mounted externally on the hollow biocompatible wire. Possibly, the hollow biocompatible wire defines an internal channel having a diameter of less than 0.5 millimeters. Optionally, the hollow biocompatible wire is not biodegradable. The at least one tubular seed may be located in the middle of the hollow biocompatible wire, at least 10 millimeters from both ends of the hollow biocompatible wire.

Abstract: When acquiring detailed utilization information from imaging equipment in a cross-vendor approach, one or more sensors (16, 18, 22, 24) are positioned within a data security zone (14) in which an imaging procedure is performed. Sensor data is pre-processed on an isolated processing unit (20) to remove any sensitive information and keep a selection of features only. The resultant feature pattern is transmitted outside of the data security zone to a processing unit (28) where pattern recognition is performed on feature pattern to identify the type of imaging modality, scan, etc. being performed as well as to determine whether the scan is being performed according to schedule.

Abstract: Aspects of this invention, inter alia, relate to novel systems for targeting, editing or manipulating DNA in a cell, using novel synthetic RNA-guided nucleases (sRGNs). The sRGNs are derived from wildtype or parental small type II CRISPR Cas9 endonucleases.

Abstract: An implant having a proximal portion, a distal portion and a central portion positioned between the proximal portion and the distal portion. The implant further includes a longitudinal axis with the proximal portion, the distal portion and the central portion being centered along the longitudinal axis. An implant system that includes an implant having a proximal portion including an opening, a distal portion including a threading, a tip, and a tapping feature at the tip, and a central portion having at least one flat on an outer surface The central portion is disposed between the proximal and distal portions. The implant system also includes an insertion instrument configured to be releasably coupled with the implant.

Abstract: An apparatus includes a support, including an outer surface and configured for insertion into a body of a subject. The apparatus further includes multiple atoms of a radionuclide, which radioactively decays to produce a daughter radionuclide, coupled to the outer surface, and a layer of a polymer, which covers the atoms so as to protect the atoms from being washed away, yet allows diffusion of the daughter radionuclide through the layer. Other embodiments are also described.

Abstract: A drivetrain assembly of a power machine can include a motor sub-assembly. The motor sub-assembly can include a bearing carrier, a reduction assembly, and an electric motor. The bearing carrier can be configured to be fixedly attached at an outboard side to a first lateral side of a frame of the power machine to operably transmit rotational power to at least one tractive element of the power machine. An outboard side of the reduction assembly can be fixedly attached to an inboard side of the bearing carrier. An inboard side of the electric motor can be fixedly attached to the outboard side of the reduction assembly and the electric motor can be configured to operably transmit the rotational power to the bearing carrier via the reduction assembly. At least part of the electric motor can laterally overlap with the bearing carrier.

Abstract: A method for manufacturing a distributor for refrigerant in components in a thermal management module is provided, distributor has distributor openings for the refrigerant on an upper surface and/or a lower surface that faces away from the upper surface. Greater reliability, reduced installation space, and greater variability in the shape of the distributor are obtained in that the distributor is produced in a casting process, in which channel sections of channels passing through the distributor are obtained with a removable core in a mold. A method for manufacturing a thermal management module that contains such a distributor, as well as a distributor produced in this manner, and a thermal management module is provided.

Abstract: The present disclosure relates to a bag for transportation of personal items. The bag includes a main body and a panel. The bag is adjustable between a shoulder carrying configuration, in particular a backpack configuration, and a pannier configuration. The bag includes a panel attachment device that is configured to provide reversible mounting of the panel to an attachment side of the main body. The bag is adjusted into the shoulder carrying configuration when the panel is mounted to the attachment side of the main body with its first side facing away from the main body and is vice versa adjusted into the pannier configuration when the panel is mounted to the attachment side of the main body with its second side opposite the first side facing away from the main body.

Abstract: Systems and methods are provided for managing Electric Vehicle Supply Equipment (EVSE) for use with a generator back-up. The EVSE can receive electrical power to generate an electrical load while monitoring a frequency of electrical power. The EVSE and/or another system may determine the generator back-up is supplying power based on the frequency. In response to determining the generator back-up is supplying power, the EVSE can operate at percentage of full power. The EVSE may attempt to reconnect and/or increase the percentage of full power in multiple ways based on a mode the EVSE is operating in. In a lock-out disabled priority mode, the EVSE can attempt to reconnect and begin operating at full power. In a lock-out mode, the EVSE can attempt to reconnect at a percentage of full power and incrementally increase the percentage of full power until full power has been reached.

Abstract: A casing holding one or more brachytherapy seeds for implanting in a patient, which in turn carry atoms of a radioactive element for radiotherapy treatment is filled with a viscous liquid in a manner preventing radiation from the one or more brachytherapy seeds from exiting the casing. The casing may include a metallic or non-metallic elongated tube configured for insertion into tissue or a vial for delivering a seed to a physician for insertion into a needle.

Abstract: A radiotherapy source for treating a tumor, which includes a flexible core impermeable to radon and a polymer coating on the flexible core. The polymer coating is impermeable to radium, and allows diffusion of radon therethrough. The radiotherapy source also includes alpha-emitting radium radionuclides in the polymer coating or between the flexible core and the polymer coating.

Abstract: Systems and methods for duplicating keys are disclosed. A key duplication system receives a key blank into a key receiving module. The key receiving module includes opposable jaws that assist with alignment of the key blank within the module. The key receiving module also includes an end stop that engages the tip of the received key blank and is linearly displaced as the key blank is further inserted. The linear displacement of the end stop is compared to a known value corresponding to a length of the shank of the key blank, and if the displacement does not match the known value, the user is instructed to re-orient the key blank.