Patents by Inventor Michaela Schmidtke

Michaela Schmidtke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ISOXAZOLE-3-CARBOXAMIDE DERIVATIVES AND THEIR USE FOR TREATMENT OF DISEASES CAUSED BY VIRUS INFECTION
    Publication number: 20220298149
    Abstract: Isoxazole-3-carboxamide derivatives and their use in treating viral infections and diseases, such as diseases caused by viruses of the Picornaviridae family of viruses (e.g., rhinoviruses, enteroviruses, and coxsackieviruses) is described. The derivatives have good efficacy against a range of viruses, including pleconaril-resistant viral strains, and have low induction of cytochrome P4503A4 (CYP3A4).
    Type: Application
    Filed: September 25, 2020
    Publication date: September 22, 2022
    Inventors: Vadim Makarov, Michaela Schmidtke, Sean Ekins
  • 4-amino-3-phenylamino-6-phenylpyrazolo[3,4-d]pyrimidine derivatives, their manufacture and their use as antiviral active substances
    Patent number: 9790225
    Abstract: The present invention relates to 5-amino-3-phenylamino-6-phenylpyrazolo[3,4-d]pyrimidine derivatives of the general formula I or pharmaceutically acceptable salts or propharmacons thereof, wherein at least one hydrogen atom in at least one of the phenyl groups A and B is substituted by a substituent RH, which has a Hammett constant ?p greater than 0.23. The present invention also concerns the method of its manufacture. For corresponding compounds, surprisingly a particularly high activity against viruses, in particular rhinoviruses and picornaviruses was determined. Furthermore, the compounds are tolerated very well. For these reasons the compounds are suitable for the treatment of viral infections and as drugs.
    Type: Grant
    Filed: October 15, 2012
    Date of Patent: October 17, 2017
    Assignee: Scandion Oncology A/S
    Inventors: Peter Wutzler, Michaela Schmidtke, Vadim Makarov
  • 4-amino-3-arylamino-6-arylpyrazolo[3,4-d) pyrimidine derivatives, methods for their preparation and their use as antiviral agents
    Patent number: 8962634
    Abstract: 4-amino-3-arylamino-6-arylpyrazolo[3,4-d]pyrimidine derivatives of general formula (I), pharmaceutically acceptable salts thereof, method for preparation of the aforesaid compounds and their use as antiviral agents.
    Type: Grant
    Filed: June 20, 2007
    Date of Patent: February 24, 2015
    Assignee: Dritte Patentportfolio Beteiligungsgesellschaft mbH & Co. KG
    Inventors: Vadim Albertovitch Makarov, Peter Wutzler, Michaela Schmidtke, Hans-Martin Dahse
  • 4-Amino-3-phenylamino-6-phenylpyrazolo[3,4-d]pyrimidine derivatives, their manufacture and their use as antiviral active substances
    Publication number: 20140296259
    Abstract: The present invention relates to 5-amino-3-phenylamino-6-phenylpyrazolo[3,4-d]pyrimidine derivatives of the general formula I or pharmaceutically acceptable salts or propharmacons thereof, wherein at least one hydrogen atom in at least one of the phenyl groups A and B is substituted by a substituent RH, which has a Hammett constant ?p greater than 0.23. The present invention also concerns the method of its manufacture. For corresponding compounds, surprisingly a particuarly high activity against viruses, in particular rhinoviruses and picornaviruses was determined. Furthermore, the compounds are tolerated very well. For these reasons the compounds are suitable for the treatment of viral infections and as drugs.
    Type: Application
    Filed: October 15, 2012
    Publication date: October 2, 2014
    Inventors: Peter Wutzler, Michaela Schmidtke, Vadim Makarov
  • 4-Amino-3-Arylamino-6-Arylpyrazolo[3,4-D) Pyrimidine Derivatives, Methods for their Preparation and their Use as Antiviral Agents
    Publication number: 20100010018
    Abstract: 4-amino-3-arylamino-6-arylpyrazolo[3,4-d]pyrimidine derivatives of general formula (I), pharmaceutically acceptable salts thereof, method for preparation of the aforesaid compounds and their use as antiviral agents.
    Type: Application
    Filed: June 20, 2007
    Publication date: January 14, 2010
    Inventors: Vadim Makarov, Peter Wutzler, Michaela Schmidtke, Hans-Martin Dahse
  • Method of treating infectious diseases with polysaccharide derivatives
    Patent number: 7297687
    Abstract: The present invention relates to a method of treating infectious diseases, that involves: (a) providing an alpha-glycosidically linked starch polysaccharide derivative; and (b) inhibiting the growth of an infectious disease by administering a composition comprising the alpha-glycosidically linked starch polysaccharide derivative. The alpha-glycosidically linked starch polysaccharide derivative represented by the following general formula I, in which: the alpha-glycosidically linked starch polysaccharide derivative has a degree of quaternary ammonium group substitution of from 0.4 to 2.
    Type: Grant
    Filed: January 10, 2003
    Date of Patent: November 20, 2007
    Assignee: Wolff Cellulosics GmbH Co. KG
    Inventors: Vera Haack, Thomas Heinze, Michaela Schmidtke, Ute Möllmann, Hans-Martin Dahse, Albert Härtl
  • Use of polysaccharide derivatives as anti-infective substances
    Publication number: 20050054609
    Abstract: The present invention relates to a method of treating infectious diseases, that involves: (a) providing an alpha-glycosidically linked starch polysaccharide derivative; and (b) inhibiting the growth of an infectious disease by administering a composition comprising the alpha-glycosidically linked starch polysaccharide derivative. The alpha-glycosidically linked starch polysaccharide derivative represented by the following general formula I, in which: the alpha-glycosidically linked starch polysaccharide derivative has a degree of quaternary ammonium group substitution of from 0.4 to 2.
    Type: Application
    Filed: January 10, 2003
    Publication date: March 10, 2005
    Inventors: Vera Haack, Thomas Heinze, Michaela Schmidtke, Ute Mollmann, Hans-Martin Dahse, Albert Hartl