Patents by Inventor Michaela Windfuhr
Michaela Windfuhr has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11959914Abstract: The automatic analyzer includes: a sample dispensing unit that dispenses a sample into a reaction vessel; a reagent dispensing unit that dispenses a reagent into the reaction vessel; a control unit that controls the sample dispensing unit and the reagent dispensing unit; and a measurement unit that measures a mixed solution of the sample and the reagent mixed in the reaction vessel. The reagent includes three types of reagents of: a first reagent that specifically binds to an antigen in the sample; a second reagent that specifically binds to a site different from that to which the first reagent binds with respect to the antigen and has a label to be detected by the measurement unit; and a third reagent that specifically binds to a site different from the binding site of the first reagent and the antigen and contains insoluble carriers.Type: GrantFiled: January 29, 2019Date of Patent: April 16, 2024Assignees: HITACHI HIGH-TECH CORPORATION, ROCHE DIAGNOSTICS OPERATIONS, INC.Inventors: Tatsuki Takakura, Kenta Imai, Takaaki Hagiwara, Yoshihiro Yamashita, Taku Sakazume, Beatus Ofenloch-Haehnle, Michaela Windfuhr, Ursula Pauselius-Fuchs, Rita Haerteis
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Publication number: 20240044804Abstract: The disclosure concerns methods for the detection of an analyte in a sample by electro-chemiluminescence using new reagent compositions. New reagent compositions, reagent kits for measuring electrochemiluminscence (ECL) and electrochemiluminescence detection methods using the new reagent compositions are disclosed. In particular, the disclosure relates to the use of novel combinations of compounds which can be used in said measurements to provide improved assay performance.Type: ApplicationFiled: August 18, 2021Publication date: February 8, 2024Inventors: Hans-Peter JOSEL, Herbert ANDRES, Michaela WINDFUHR, Oliver LARBOLETTE, Stefan QUINT
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Patent number: 11740254Abstract: The object of the invention is to provide an automatic analysis apparatus capable of setting a dispensing mechanism for measuring dispensing accuracy and a dispensing volume, and capable of performing dispensing accuracy measurement without absorbance measurement. Regarding a dispensing accuracy, a dispensing mechanism to be measured is designated. Parameters including a dispensing volume and the like are input. A dispensing operation of the input dispensing volume is automatically performed for each designated dispensing mechanism. A reaction vessel contains, for example, a reagent of the input dispensing volume which has been dispensed by the designated dispensing mechanism. By measuring a weight of the reagent in the reaction vessel, or the like, it is possible to measure the dispensing accuracy of the designated dispensing mechanism.Type: GrantFiled: November 29, 2018Date of Patent: August 29, 2023Assignees: Hitachi High-Tech Corporation, Roche Diagnostics Operations, Inc.Inventors: Yuichiro Ota, Takaaki Hagiwara, Yoshihiro Yamashita, Koshin Hamasaki, Michaela Windfuhr, Heike Guggemos, Johannes Stoeckel, Guenter Ziegler, Michael Kuehnl
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Patent number: 11517636Abstract: An analyzer that has a simple configuration, that is inexpensive, that can improve safety, and that can inhibit proliferation of microorganisms using ultraviolet light is realized. A first electric power switch, a second electric power switch, and a third electric power switch are connected in series between an ultraviolet LED that irradiates an interior of a shared reagent storage container with ultraviolet light and a power supply that supplies electric power to the ultraviolet LED. The first electric power switch, the second electric power switch, and the third electric power switch are configured with two contact points and a connection section that connects and disconnects the two contact points. The first electric power switch is opened when a reagent storage door is opened, and the second electric power switch is opened in response to an action of extracting an ultraviolet irradiation section from a shared reagent storage container.Type: GrantFiled: September 10, 2018Date of Patent: December 6, 2022Assignees: Hitachi High-Tech Corporation, Roche Diagnostics Operations, Inc.Inventors: Hisashi Yabutani, Takeshi Ishida, Yoshihiro Yamashita, Taku Sakazume, Michaela Windfuhr, Bernhard Hauptmann, Andreas Finke
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Publication number: 20220283094Abstract: An analysis method includes: an inflow process of a solution containing a test object, a magnetic support on the surface of which a complex including an antibody labeled with a luminescent agent and recognizes the test object is formed, and a reaction aid to assist reaction of the luminescent agent in a flow cell; a process of capturing the magnetic support over a working electrode by a magnetic field; a process of making the luminescent agent illuminate by applying a voltage to the working electrode; and a process of measuring an amount of luminescence of the luminescent agent. The luminescent process includes: luminescence from action of a first neutral radical, produced from the reaction aid through a cation radical; and luminescence from action of a second neutral radical, produced not through a cation radical, on the luminescent agent. This increases the luminous efficiency of ECL and enhances detection sensitivity.Type: ApplicationFiled: July 31, 2019Publication date: September 8, 2022Applicants: Hitachi High-Tech Corporation, Roche Diagnostics Operations, Inc.Inventors: Toshiro SAITO, Kyoko IMAI, Francesco PAOLUCCI, Massimo MARCACCIO, Giovanni VALENTI, Alessandra ZANUT, Michaela WINDFUHR, Hans-Peter JOSEL
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Patent number: 11293934Abstract: An automatic analyzer is equipped with a sterilization mechanism removably attached to an opening of a container that holds a reagent and having an ultraviolet light generation section that radiates ultraviolet light; a suction nozzle removably attached, together with the sterilization mechanism, to the opening of the container; an analysis section adding the reagent drawn in by suction from the container via the suction nozzle to the reagent, and executing an analysis operation; and a control section exercising variable control over an irradiation light intensity of the ultraviolet light generated by the ultraviolet light generation section.Type: GrantFiled: April 24, 2017Date of Patent: April 5, 2022Assignees: Hitachi High-Tech Corporation, Roche Diagnostics Operations, Inc.Inventors: Takeshi Ishida, Sakuichiro Adachi, Yoshihiro Yamashita, Shunichirou Nobuki, Hisashi Yabutani, Isao Yamazaki, Michaela Windfuhr, Bernhard Hauptmann, Simon Kuester
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Publication number: 20210381987Abstract: The disclosure concerns methods for the detection of an analyte in a sample by electro-chemiluminescence using new reagent compositions. New reagent compositions, reagent kits for measuring electrochemiluminscence (ECL) and electrochemiluminescence detection methods using the new reagent compositions are disclosed. In particular, the disclosure relates to the use of novel combinations of compounds which can be used in said measurements to provide improved assay performance.Type: ApplicationFiled: August 18, 2021Publication date: December 9, 2021Inventors: Hans-Peter JOSEL, Herbert ANDRES, Michaela WINDFUHR, Oliver LARBOLETTE, Stefan QUINT
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Patent number: 11125695Abstract: The disclosure concerns methods for the detection of an analyte in a sample by electrochemiluminescence using new reagent compositions. New reagent compositions, reagent kits for measuring electrochemiluminscence (ECL) and electrochemiluminescence detection methods using the new reagent compositions are disclosed. In particular, the disclosure relates to the use of novel combinations of compounds which can be used in said measurements to provide improved assay performance.Type: GrantFiled: August 24, 2018Date of Patent: September 21, 2021Inventors: Hans-Peter Josel, Herbert Andres, Michaela Windfuhr, Oliver Larbolette, Stefan Quint
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Publication number: 20200240981Abstract: The automatic analyzer includes: a sample dispensing unit that dispenses a sample into a reaction vessel; a reagent dispensing unit that dispenses a reagent into the reaction vessel; a control unit that controls the sample dispensing unit and the reagent dispensing unit; and a measurement unit that measures a mixed solution of the sample and the reagent mixed in the reaction vessel. The reagent includes three types of reagents of: a first reagent that specifically binds to an antigen in the sample; a second reagent that specifically binds to a site different from that to which the first reagent binds with respect to the antigen and has a label to be detected by the measurement unit; and a third reagent that specifically binds to a site different from the binding site of the first reagent and the antigen and contains insoluble carriers.Type: ApplicationFiled: January 29, 2019Publication date: July 30, 2020Inventors: Tatsuki TAKAKURA, Kenta IMAI, Takaaki HAGIWARA, Yoshihiro YAMASHITA, Taku SAKAZUME, Beatus OFENLOCH-HAEHNLE, Michaela WINDFUHR, Ursula PAUSELIUS-FUCHS, Rita HAERTEIS
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Publication number: 20200209273Abstract: The object of the invention is to provide an automatic analysis apparatus capable of setting a dispensing mechanism for measuring dispensing accuracy and a dispensing volume, and capable of performing dispensing accuracy measurement without absorbance measurement. Regarding a dispensing accuracy, a dispensing mechanism to be measured is designated. Parameters including a dispensing volume and the like are input. A dispensing operation of the input dispensing volume is automatically performed for each designated dispensing mechanism. A reaction vessel contains, for example, a reagent of the input dispensing volume which has been dispensed by the designated dispensing mechanism. By measuring a weight of the reagent in the reaction vessel, or the like, it is possible to measure the dispensing accuracy of the designated dispensing mechanism.Type: ApplicationFiled: November 29, 2018Publication date: July 2, 2020Inventors: Yuichiro OTA, Takaaki HAGIWARA, Yoshihiro YAMASHITA, Koshin HAMASAKI, Michaela WINDFUHR, Heike GUGGEMOS, Johannes STOECKEL, Guenter ZIEGLER, Michael KUEHNL
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Publication number: 20200171182Abstract: An analyzer that has a simple configuration, that is inexpensive, that can improve safety, and that can inhibit proliferation of microorganisms using ultraviolet light is realized. A first electric power switch, a second electric power switch, and a third electric power switch are connected in series between an ultraviolet LED that irradiates an interior of a shared reagent storage container with ultraviolet light and a power supply that supplies electric power to the ultraviolet LED. The first electric power switch, the second electric power switch, and the third electric power switch are configured with two contact points and a connection section that connects and disconnects the two contact points. The first electric power switch is opened when a reagent storage door is opened, and the second electric power switch is opened in response to an action of extracting an ultraviolet irradiation section from a shared reagent storage container.Type: ApplicationFiled: September 10, 2018Publication date: June 4, 2020Inventors: Hisashi YABUTANI, Takeshi ISHIDA, Yoshihiro YAMASHITA, Taku SAKAZUME, Michaela WINDFUHR, Bernhard HAUPTMANN, Andreas FINKE
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Publication number: 20190310275Abstract: An automatic analyzer is equipped with a sterilization mechanism removably attached to an opening of a container that holds a reagent and having an ultraviolet light generation section that radiates ultraviolet light; a suction nozzle removably attached, together with the sterilization mechanism, to the opening of the container; an analysis section adding the reagent drawn in by suction from the container via the suction nozzle to the reagent, and executing an analysis operation; and a control section exercising variable control over an irradiation light intensity of the ultraviolet light generated by the ultraviolet light generation section.Type: ApplicationFiled: April 24, 2017Publication date: October 10, 2019Inventors: Takeshi ISHIDA, Sakuichiro ADACHI, Yoshihiro YAMASHITA, Shunichirou NOBUKI, Hisashi YABUTANI, Isao YAMAZAKI, Michaela WINDFUHR, Bernhard HAUPTMANN, Simon KUESTER
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Publication number: 20180364175Abstract: The disclosure concerns methods for the detection of an analyte in a sample by electrochemiluminescence using new reagent compositions. New reagent compositions, reagent kits for measuring electrochemiluminscence (ECL) and electrochemiluminescence detection methods using the new reagent compositions are disclosed. In particular, the disclosure relates to the use of novel combinations of compounds which can be used in said measurements to provide improved assay performance.Type: ApplicationFiled: August 24, 2018Publication date: December 20, 2018Applicant: Roche Diagnostics Operations, Inc.Inventors: Hans-Peter Josel, Herbert Andres, Michaela Windfuhr, Oliver Larbolette, Stefan Quint
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Patent number: 9341575Abstract: The application provides methods for the detection of an analyte in a sample by electrochemiluminescence using certain reagent compositions. Reagent compositions, reagent kits for measuring electrochemiluminescence (ECL) and electrochemiluminescence detection methods using the reagent compositions are disclosed. In particular, the application relates to the use of novel combinations of compounds, which can be used in said measurements to provide improved ECL assay performance.Type: GrantFiled: March 15, 2013Date of Patent: May 17, 2016Assignee: Roche Diagnostics Operations, Inc.Inventors: Andreas Finke, Bernhard Hauptmann, Johannes Stoeckel, Michaela Windfuhr
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Publication number: 20130224758Abstract: The application provides methods for the detection of an analyte in a sample by electrochemiluminescence using certain reagent compositions. Reagent compositions, reagent kits for measuring electrochemiluminescence (ECL) and electrochemiluminescence detection methods using the reagent compositions are disclosed. In particular, the application relates to the use of novel combinations of compounds, which can be used in said measurements to provide improved ECL assay performance.Type: ApplicationFiled: March 15, 2013Publication date: August 29, 2013Applicant: Roche Diagnostics Operations, Inc.Inventors: Andreas Finke, Bernhard Hauptmann, Johannes Stoeckel, Michaela Windfuhr