Abstract: The present invention relates to a compound of formula (I), pharmaceutically acceptable salts thereof as well as pharmaceutical compositions, for use in a method of topical treatment of a skin disease or skin disorder of a mammal, wherein said method comprises topical administration of said compound to said mammal, Formula (I) wherein R1 is selected from carbocyclyl or heterocyclyl, each independently optionally substituted with C1-C4alkyl, halogen, oxo, CF3, OR4, NR5R6, C6H5, C6H5 substituted with halogen, C1-C3alkyl, OR4, NR5R6, wherein R4, R5, R6 are independently at each occurrence H, C1-C3alkyl; R2 is selected from C5-C12alkyl, C4-C10alkoxy, C1-C3 alkylene-cycloalkyl, C1-C3alkylene-aryl, C1-C3alkylene-heteroaryl, wherein said alkyl, cycloalkyl, aryl and heteroaryl are each independently optionally substituted with one or more, typically and preferably one or two, substituents selected from C1-C2 alkyl, C1-C2 haloalkyl, halogen, C1-C2 alkoxy; R3 is (Ia), wherein R7, R8, R9 and R10 are independently at eac

Abstract: In the present application, alkalization of cocoa natural products may be carried out by using a stable alkaline water (pH levels of up to 10.5 or more) with the aim to produce alkalized chocolate products with pleasant organoleptic, less sugar content, less acidity, high antioxidants contents, and addition of novel soluble ingredients to chocolate. This can be achieved by using the stable alkaline water produced by a Natralysis Process in alkalizing cocoa nibspre, during and post grinding, alkalizing the cocoa liquor and alkalizing the natural cocoa powder. The present application discloses a method or apparatus (3, 9, 15) in which a cocoa natural product and/or one or more of its derivatives is alkalized by using stable alkaline water.

Abstract: The present invention is directed to an apparatus for securing brush to a fixed wooden object to create a hunting blind, the apparatus having a screw having a head and a tip at opposing ends of the screw, the head having a head diameter; and a flange secured to the screw proximate the head, the flange being substantially circular and having a top surface, a base, a flange diameter at least twice the head diameter, a plurality of protrusions situated about an outer edge of the flange, a plurality of recesses, each of the plurality of recesses being disposed about the outer edge of the flange between two of the protrusions and each of the plurality of recesses being configured to receive a user's palm, thumb, and/or fingers to rotate the apparatus, and one or more holes or indentations positioned on or adjacent to at least one of the protrusions.

Abstract: The invention relates to a structural multilayer composite comprising a layer of leather in contact with at least one monolayer comprising parallel aligned fibers and a matrix material. The composite may further comprise film layer(s) that may be breathable and/or waterproof. The structural multilayer composite material is suitable for use in clothing and outdoor gear and apparel.

Abstract: The invention relates to a multilayer composite comprising a layer of leather in contact with at least one monolayer comprising parallel aligned fibers and a matrix material. The composite may further comprise film layer(s) that may be breathable and/or waterproof. The multilayer composite material is suitable for use in clothing and outdoor gear and apparel.

Abstract: Inflatable medical devices and methods for making and using the same are disclosed. The inflatable medical devices can be medical balloons. The balloons can be configured to have a through-lumen or no through-lumen and a wide variety of geometries. The device can have a high-strength, non-compliant, fiber-reinforced, multi-layered wall. The inflatable medical device can be used for angioplasty, kyphoplasty, percutaneous aortic valve replacement, or other procedures described herein.

Abstract: According to various embodiments, a data processing device may be provided.

Abstract: The present patent application relates to a novel coating system, wherein the coating comprises Carnauba wax and at least one polysorbate. Furthermore it relates to compositions coated with such a coating system and the use of such compositions in the production of tablets.

Abstract: A yeast-free dough contains at least 40% natural cheese. The natural cheese is mixed with wheat flour, pregelatinized starch, and water to make a non-laminated dough, which is then sheeted, cut and dehydrated. The finished product has a peak force hardness of between about 15,000 to about 30,000 grams and an expanded internal air cell structure throughout and a bulk density of from about 100 to about 400 g/L.

Abstract: Inflatable medical devices and methods for making and using the same are disclosed. The inflatable medical devices can be medical balloons. The balloons can be configured to have a through-lumen or no through-lumen and a wide variety of geometries. The device can have a high-strength, non-compliant, fiber-reinforced, multi-layered wall. The inflatable medical device can be used for angioplasty, kyphoplasty, percutaneous aortic valve replacement, or other procedures described herein.

Abstract: The present invention provides a compound of formula (I): wherein X is N or CH, Y is NH, O or S, methods for manufacturing these compounds, and their uses as Factor B inhibitors for the treatment of conditions and diseases associated with complement alternative pathway activation such as age-related macular degeneration, diabetic retinopathy and related ophthalmic diseases. The present invention further provides pharmaceutical compositions and combinations of pharmacologically active agents.

Abstract: The present invention provides a compound of formula I: a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Abstract: The present invention provides novel organic compounds of Formula (I): methods of use, and pharmaceutical compositions thereof.

Abstract: Biological navigation devices and methods are disclosed. The devices can be used as or to support colonoscopies or endoscopes. The devices can have one or more releasable, and/or everting, and/or pressurized tubes. The devices can be removably attached to elongated elements, such as colonoscopes or other endoscopes.

Abstract: The present invention relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, intermediates thereto, and uses thereof. QS-7 is a potent immuno-adjuvant that is significantly less toxic than QS-21, a related saponin that is currently the favored adjuvant in anticancer and antiviral vaccines. Tedious isolation and purification protocols have hindered the clinical development of QS-7. A novel semi-synthetic method is provided wherein a hydrolyzed prosapogenin mixture is used to synthesize QS-7, QS-21, and related analogs, greatly facilitating access to QS-7 and QS-21 analogs for preclinical and clinical evaluation.

Abstract: The present invention provides a compound of formula I: a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Abstract: The present invention provides novel organic compounds of Formula (I): methods of use, and pharmaceutical compositions thereof.

Abstract: A device is disclosed for therapeutic and/or diagnostic use in or on a patient's body. The device can have a sheath and a tool. The sheath can be made, at least in part, from a laminate. The laminate can have reinforcement fibers in longitudinal, latitudinal, helical, and/or other configurations around the sheath. The tool can be at least partially within the sheath. The tool can be attached to the sheath at one or more lengths along the tool. The sheath can be removed from the tool and replaced.

Abstract: The present invention provides a compound of formula I: a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Abstract: The present invention provides a compound of formula I: (I) a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.