Patents by Inventor Michail Ziovas

Michail Ziovas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SOLID PHASE PEPTIDE SYNTHESIS OF INSULIN USING SIDE CHAIN ANCHORED LYSINE
    Publication number: 20210388051
    Abstract: The present application discloses the preparation of peptides, including insulin and insulin derivatives, using efficient methods for solid-phase and solution phase peptide synthesis.
    Type: Application
    Filed: June 16, 2021
    Publication date: December 16, 2021
    Inventors: Kleomenis K. Barlos, Konstantinos Barlos, Dimitrios Gatos, Michail Ziovas, Efstathios Liopyris
  • Biologically active insulin derivatives
    Patent number: 10195287
    Abstract: A first aspect of the invention relates to a single chain insulin analog comprising: (A) the A-chain of human or animal insulin, or an analog or derivative thereof; (B) the B-chain of human or animal insulin, or an analog or derivative thereof; (C) one or more disulfide bonds between said A-chain and said B-chain; and (D) a further covalent link, L, between a functional group of an amino acid in the A-chain and a functional group of an amino acid in the B-chain, at least one of said functional groups being an amino acid side chain functional group. Further aspects of the invention relate to pharmaceutical compositions comprising said single chain insulin derivatives, and therapeutic uses thereof.
    Type: Grant
    Filed: December 4, 2014
    Date of Patent: February 5, 2019
    Assignee: CHEMICAL & BIOPHARMACEUTICALS LABORATORIES OF PATRAS S.A.
    Inventors: Kleomenis Barlos, Dimitrios Gatos, Kostas Barlos, Michail Ziovas
  • Biologically Active Insulin Derivatives
    Publication number: 20160375146
    Abstract: A first aspect of the invention relates to a single chain insulin analogue comprising: (A) the A-chain of human or animal insulin, or an analogue or derivative thereof; (B) the B-chain of human or animal insulin, or an analogue or derivative thereof; (C) one or more disulfide bonds between said A-chain and said B-chain; and (D) a further covalent link, L, between a functional group of an amino acid in the A-chain and a functional group of an amino acid in the B-chain, at least one of said functional groups being an amino acid side chain functional group. Further aspects of the invention relate to pharmaceutical compositions comprising said single chain insulin derivatives, and therapeutic uses thereof.
    Type: Application
    Filed: December 4, 2014
    Publication date: December 29, 2016
    Inventors: Kleomenis Barlos, Dimitrios Gatos, Kostas Barlos, Michail Ziovas