Patents by Inventor Michal Dousa

Michal Dousa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PHARMACEUTICAL COMPOSITIONS WITH LOW AMOUNTS OF NITROSAMINE IMPURITIES AND METHODS FOR PRODUCING THE SAME
    Publication number: 20230390221
    Abstract: The present invention relates to pharmaceutical compositions comprising metformin with low amounts of nitrosamine impurities and methods for producing the same. More specifically, the present invention relates to methods and compositions that reduce the amount of nitrosable compounds in the active pharmaceutical ingredient and/or reduce the conversion of nitrosable compounds into nitrosamines in the finished dosage form.
    Type: Application
    Filed: October 15, 2021
    Publication date: December 7, 2023
    Applicant: Zentiva K.S.
    Inventors: Jaroslav RIHA, Ludek RIDVAN, Michal DOUSA, Tomas KUBELKA, Petr GIBALA, Frantisek BARTACEK, Pawel STASIAK, Stanislav KALASEK, Anna Kluk, Vít Zvonícek
  • METHOD FOR THE MANUFACTURE OF HIGHLY PURE PRASUGREL
    Publication number: 20110282064
    Abstract: The invention deals with preparation of the substance prasugrel, using 3-cyclopropyl-1-(2-fluorophenyl)-3-oxopropyl methanesulfonate for alkylation of 2-oxo-thienotetrahydropyridine, which may be in the form of a salt, e.g. with hydrochloric acid or p-toluenesulfonic acid. The resulting compound of formula II is acylated, preferably with acetanhydride, preferably directly in the reaction mixture without isolation, and the produced prasugrel of formula I can then be crystallized directly from the reaction mixture.
    Type: Application
    Filed: November 24, 2009
    Publication date: November 17, 2011
    Inventors: Hana Stepankova, Josef Hajicek, Michal Dousa