Abstract: Provided herein is a method for treating a human subject afflicted with ALS by administering to the subject a therapeutically effective amount of pridopidine.

Abstract: Provided herein is a method for treating a human subject afflicted with ALS by administering to the subject a therapeutically effective amount of pridopidine as monotherapy or together with riluzole, edaravone, combination of dextromethorphan/quinidine, sodium phenylbutyrate (PB), tauroursodeoxycholic acid or combination of sodium phenylbutyrate (PB)/tauroursodeoxycholic acid (i.e. AMX0035) as combination or add-on therapy.

Abstract: This invention provides a method of improving cognitive function in a subject comprising periodically administering to the subject an amount of pridopidine or a pharmaceutically acceptable salt thereof effective to improve a cognitive function in the subject. The invention also provides a method of treating a subject afflicted with Alzheimer's disease, comprising periodically administering to the subject a pharmaceutical composition comprising an amount of pridopidine or a pharmaceutically acceptable salt thereof effective to treat the subject.

Abstract: This invention provides a method of improving cognitive function in a subject comprising periodically administering to the subject an amount of pridopidine or a pharmaceutically acceptable salt thereof effective to improve a cognitive function in the subject. The invention also provides a method of treating a subject afflicted with Alzheimer's disease, comprising periodically administering to the subject a pharmaceutical composition comprising an amount of pridopidine or a pharmaceutically acceptable salt thereof effective to treat the subject.

Abstract: The invention provides a method of treating a subject afflicted with a drug-induced movement disorder including levodopa-induced dyskinesia comprising periodically administering to the subject in need thereof an amount of pridopidine effective to treat the subject. The invention further provides a method of treating a subject at risk of developing a drug-induced movement disorder, including levodopa-induced dyskinesia. The invention also provides pharmaceutical compositions suitable for carrying out these methods and packages containing such pharmaceutical compositions.

Abstract: The invention provides a method of treating a subject afflicted with a drug-induced movement disorder including levodopa-induced dyskinesia comprising periodically administering to the subject in need thereof an amount of pridopidine effective to treat the subject. The invention further provides a method of treating a subject at risk of developing a drug-induced movement disorder, including levodopa-induced dyskinesia. The invention also provides pharmaceutical compositions suitable for carrying out these methods and packages containing such pharmaceutical compositions.

Abstract: The subject invention provides a method of treating a subject afflicted with a neurodegenerative eye disease comprising administering to the subject an amount of pridopidine effective to treat the subject.

Abstract: This invention provides a method of improving cognitive function in a subject comprising periodically administering to the subject an amount of pridopidine or a pharmaceutically acceptable salt thereof effective to improve a cognitive function in the subject. The invention also provides a method of treating a subject afflicted with Alzheimer's disease, comprising periodically administering to the subject a pharmaceutical composition comprising an amount of pridopidine or a pharmaceutically acceptable salt thereof effective to treat the subject.

Abstract: A tissue access site system and methods for opening and closing a tissue access site are provided. A method for opening and closing an access site in a body lumen includes attaching a plurality of closure elements to a perimeter wall of a body lumen by advancing closure elements from an access and closure device associated with a guide wire positioned through the perimeter wall. A tissue cutting element of the access and closure device is advanced along the guide wire to cause the tissue cutting element to penetrate through the perimeter wall to open an access site in the perimeter wall that includes a plurality of tissue flaps. Each of the tissue flaps has a predetermined geometry and is attached to at least one of the closure elements. The closure elements are used to close the access site.

Abstract: A tissue access site system is provided. In one embodiments, the system includes a tissue cutting element designed for generating a tissue access site through a tissue, the tissue access site being surrounded by tissue edge portions of a predetermined geometry; and a tissue closure device being for attaching at least one closure element to the tissue at a region corresponding to at least one of the tissue edge portions.

Abstract: A tissue access site system is provided. In one embodiments, the system includes a tissue cutting element designed for generating a tissue access site through a tissue, the tissue access site being surrounded by tissue edge portions of a predetermined geometry; and a tissue closure device being for attaching at least one closure element to the tissue at a region corresponding to at least one of the tissue edge portions.

Abstract: A computing application for a mobile information device is generated from An extensible markup language, MIDML, in which different types of tags correspond to different application functions. A command line compiler parses the MIDML specification, reading the tags in specialized readers, which are then accessed by generators of specialized objects for an object model using different generators for each type. A predefined set of tags is extendible by the application developer. The generation process results in Java source code, which is then compiled into a MIDlet and packaged into a JAR file and a JAD file.

Abstract: A testing harness for a design-under-test is modified to include a standalone implementation of an application programming interface used in developing the design-under-test. The standalone implementation is adapted to a target device, and is packaged with an executable application or MIDlet, together with any needed resource files. Either the package, or optionally a JAR and JAD file, is downloaded to a remote user for execution on the target device. Using the application programming interface and the other downloaded files, the remote user can test the target device, analyze the results, and even modify the test conditions without recourse to the testing harness. The arrangement provides a capability for a party who is not privileged to know details of the testing harness to practically evaluate and modify the design-under-test using a standalone testing application.

Abstract: A testing harness for a design-under-test is modified to include a standalone implementation of an application programming interface used in developing the design-under-test. The standalone implementation is adapted to a target device, and is packaged with an executable application or MIDlet, together with any needed resource files. Either the package, or optionally a JAR and JAD file, is downloaded to a remote user for execution on the target device. Using the application programming interface and the other downloaded files, the remote user can test the target device, analyze the results, and even modify the test conditions without recourse to the testing harness. The arrangement provides a capability for a party who is not privileged to know details of the testing harness to practically evaluate and modify the design-under-test using a standalone testing application.

Abstract: A computing application for a mobile information device is generated from An extensible markup language, MIDML, in which different types of tags correspond to different application functions. A command line compiler parses the MIDML specification, reading the tags in specialized readers, which are then accessed by generators of specialized objects for an object model using different generators for each type. A predefined set of tags is extendible by the application developer. The generation process results in Java source code, which is then compiled into a MIDlet and packaged into a JAR file and a JAD file.

Abstract: An infrastructure is provided for creating MIDlet applications on demand for mobile information devices, using a tag-based markup language. A servlet running on a web server, acknowledges the request of the remote mobile information device for an application. If the requested MIDlet is found in the server's cache, it is downloaded to the requester. Otherwise, the servlet identifies the characteristics of the mobile information device, and identifies resources that are required to produce an updated MIDlet in order to satisfy the request. A compiler is then invoked to generate the requested MIDlet, which is then packaged and downloaded over-the-air to the requestor.