Patents by Inventor Michal Hocek
Michal Hocek has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240343754Abstract: The invention provides 7-substituted 7-deazaadenine-containing 2?,3?-cyclic dinucleotides of general formula I, wherein R is selected from the group comprising C1-C5 alkyl; C6-C16 aryl, optionally substituted by at least one substituent selected from C6-C16 aryl or (C6-C16 aryloxy) C1-C5 alkyl; C4-C12 heteroaryl, comprising at least one O atom; C4-C12 heteroaryl, comprising at least one S atom, and pharmaceutically acceptable salts thereof. The compounds according to the invention show strong activation of protein STING (stimulator of interferon genes) and, consequently, stimulation of the signal transduction pathway that induces interferons and other cytokines/chemokines.Type: ApplicationFiled: August 15, 2022Publication date: October 17, 2024Inventors: Michal HOCEK, Gabriel BIRKUS, Pavla PERLIKOVA, Zdenek VAVRINA, Barbora NOVOTNA
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Patent number: 11299510Abstract: Substituted pyridopyrrolopyrimidine ribonucleosides of general formula I, wherein R is as described in the independent claim, preferably R is selected from the group comprising thiophen-3-yl, furan-2-yl, furan-3-yl, benzofuran-2-yl, methylsulfanyl, methoxy, amino, dimethylamino, methyl; and pharmaceutically acceptable salt thereof, their optical isomers and mixtures of such optical isomers. Compounds according to the invention show strong cytostatic and cytotoxic effects on cell lines of tumor origin in a wide variety of diseases including tumors of different histogenetic origin.Type: GrantFiled: March 4, 2019Date of Patent: April 12, 2022Assignees: USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I., UNIVERZITA PALACKEHO V OLOMOUCIInventors: Lucia Veselovska, Michal Hocek, Marian Hajduch, Petr Dzubak
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Publication number: 20210002321Abstract: Substituted pyridopyrrolopyrimidine ribonucleosides of general formula I, wherein R is as described in the independent claim, preferably R is selected from the group comprising thiophen-3-yl, furan-2-yl, furan-3-yl, benzofuran-2-yl, methylsulfanyl, methoxy, amino, dimethylamino, methyl; and pharmaceutically acceptable salt thereof, their optical isomers and mixtures of such optical isomers. Compounds according to the invention show strong cytostatic and cytotoxic effects on cell lines of tumor origin in a wide variety of diseases including tumors of different histogenetic origin.Type: ApplicationFiled: March 4, 2019Publication date: January 7, 2021Applicants: USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I., UNIVERZITA PALACKEHO V OLOMOUCIInventors: Lucia VESELOVSKA, Michal HOCEK, Marian HAJDUCH, Petr DZUBAK
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Patent number: 10730905Abstract: Substituted heteropentadieno-pyrrolopyrimidine ribonucleosides of general formula I, where R is selected from the group comprising furan-2-yl, furan-3-yl, benzofuran-2-yl, methylsulfanyl, methoxy, amino, dimethylamino, methyl or chloro, and pharmaceutically acceptable salt thereof, their optical isomers and mixtures of such optical isomers.Type: GrantFiled: July 31, 2017Date of Patent: August 4, 2020Assignees: USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I., UNIVERZITA PALACKEHO V OLOMOUCIInventors: Michal Hocek, Anna Tokarenko, Sabina Smolen, Marian Hajduch, Petr Dzubak
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Patent number: 10414788Abstract: A group of substituted thienopyrrolopyrimidine ribonucleosides of general formula I, in which R shows strong cytostatic and cytotoxic activities preferably against cancer cell lines of broad spectrum of diseases including tumors of various histogenetic origin.Type: GrantFiled: June 29, 2016Date of Patent: September 17, 2019Assignees: USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I., UNIVERZITA PALACKEHO V OLOMOUCIInventors: Michal Hocek, Michal Tichy, Marian Hajduch, Petr Dzubak
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Patent number: 10294262Abstract: The invention provides compounds of formula I, wherein R1, R2 and R3 have values defined in the specification and a pharmaceutically acceptable salt thereof; or an optical isomer thereof; or a mixture of optical isomers, as well as compositions comprising such compounds and therapeutic methods that utilize such compounds and/or compositions.Type: GrantFiled: March 8, 2017Date of Patent: May 21, 2019Assignee: INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I.Inventors: Aurelie Bourderioux, Michal Hocek, Petr Naus
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Publication number: 20190144486Abstract: Substituted heteropentadieno-pyrrolopyrimidine ribonucleosides of general formula I, where R is selected from the group comprising furan-2-yl, furan-3-yl, benzofuran-2-yl, methylsulfanyl, methoxy, amino, dimethylamino, methyl or chloro, and pharmaceutically acceptable salt thereof, their optical isomers and mixtures of such optical isomers.Type: ApplicationFiled: July 31, 2017Publication date: May 16, 2019Applicants: USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I., UNIVERZITA PALACKEHO V OLOMOUCIInventors: Michal HOCEK, Anna TOKARENKO, Sabina SMOLEN, Marian HAJDUCH, Petr DZUBAK
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Publication number: 20190144487Abstract: A group of substituted thienopyrrolopyrimidine ribonucleosides of general formula I, in which R shows strong cytostatic and cytotoxic activities preferably against cancer cell lines of broad spectrum of diseases including tumors of various histogenetic origin.Type: ApplicationFiled: June 29, 2016Publication date: May 16, 2019Applicants: USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I., UNIVERZITA PALACKEHO V OLOMOUCIInventors: MICHAL HOCEK, Michal TICHY, Marian HAJDUCH, Petr DZUBAK
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Publication number: 20170240584Abstract: The invention provides compounds of formula I, wherein R1, R2 and R3 have values defined in the specification and a pharmaceutically acceptable salt thereof; or an optical isomer thereof; or a mixture of optical isomers, as well as compositions comprising such compounds and therapeutic methods that utilize such compounds and/or compositions.Type: ApplicationFiled: March 8, 2017Publication date: August 24, 2017Inventors: Aurelie Bourderioux, Michal Hocek, Petr Naus
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Patent number: 9624257Abstract: The invention provides compounds of formula I: wherein R1, R2 and R3 have values defined in the specification and a pharmaceutically acceptable salt thereof; or an optical isomer thereof; or a mixture of optical isomers, as well as compositions comprising such compounds and therapeutic methods that utilize such compounds and/or compositions.Type: GrantFiled: March 17, 2016Date of Patent: April 18, 2017Assignee: Institute of Organic Chemistry and Biochemistry of the ASCR, V.V.I.Inventors: Aurelie Bourderioux, Michal Hocek, Petr Naus
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Patent number: 9586986Abstract: Compounds of Formula I and a pharmaceutically acceptable salt thereof, an optical isomer thereof, or a mixture of optical isomers thereof, as well as compositions which include such compounds and therapeutic methods that utilize such compounds and/or compositions.Type: GrantFiled: December 5, 2014Date of Patent: March 7, 2017Assignees: INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I., PALACKY UNIVERSITY IN OLOMOUCInventors: Michal Hocek, Petr Naus, Olga Caletkova, Marian Hajduch, Petr Dzubak
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Publication number: 20160318970Abstract: The invention provides compounds of formula I: wherein R1, R2 and R3 have values defined in the specification and a pharmaceutically acceptable salt thereof; or an optical isomer thereof; or a mixture of optical isomers, as well as compositions comprising such compounds and therapeutic methods that utilize such compounds and/or compositions.Type: ApplicationFiled: March 17, 2016Publication date: November 3, 2016Inventors: Aurelie BOURDERIOUX, Michal Hocek, Petr Naus
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Publication number: 20160159844Abstract: Compounds of Formula I and a pharmaceutically acceptable salt thereof, an optical isomer thereof, or a mixture of optical isomers thereof, as well as compositions which include such compounds and therapeutic methods that utilize such compounds and/or compositions.Type: ApplicationFiled: December 5, 2014Publication date: June 9, 2016Applicants: Institute of Organic Chemistry and Biochemistry ASCR, v.v.i., Palacky University in OlomoucInventors: Michal HOCEK, Petr NAUS, Olga CALETKOVA, Marian HAJDUCH, Petr DZUBAK
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Patent number: 9321800Abstract: The invention provides compounds of formula I, wherein R1, R2 and R3 have values defined in the specification and a pharmaceutically acceptable salt thereof; or an optical isomer thereof; or a mixture of optical isomers, as well as compositions comprising such compounds and therapeutic methods that utilize such compounds and/or compositions.Type: GrantFiled: April 19, 2010Date of Patent: April 26, 2016Assignee: Gilead Sciences, Inc.Inventors: Aurelie Bourderioux, Michal Hocek, Petr Naus
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Publication number: 20150218201Abstract: The invention provides compounds of formula I, wherein R1, R2 and R3 have values defined in the specification and a pharmaceutically acceptable salt thereof; or an optical isomer thereof; or a mixture of optical isomers, as well as compositions comprising such compounds and therapeutic methods that utilize such compounds and/or compositions.Type: ApplicationFiled: April 19, 2010Publication date: August 6, 2015Applicant: Institute of Organic Chemistry and Biochemistry ASCR, V.V.I.Inventors: Aurelie Bourderioux, Michal Hocek, Petr Naus
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Patent number: 8093226Abstract: The invention provides compounds of formula I: wherein R1 and R2 have any of the values defined in the specification and salts thereof, as well as compositions comprising such compounds and therapeutic methods that utilize such compounds.Type: GrantFiled: January 15, 2009Date of Patent: January 10, 2012Assignee: Institute of Organic Chemistry and Biochemistry of the ASCR, V.V.I.Inventors: Michal Hocek, Petr Naus
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Publication number: 20090203637Abstract: The invention provides compounds of formula I: wherein R1 and R2 have any of the values defined in the specification and salts thereof, as well as compositions comprising such compounds and therapeutic methods that utilize such compounds.Type: ApplicationFiled: January 15, 2009Publication date: August 13, 2009Inventors: Michal Hocek, Petr Naus
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Publication number: 20060128956Abstract: The invention provides a synthetic method of (purin-6-yl)amino acids which are useful as medicaments of anticancer, anti-virus agents and so on or their intermediates. Methyl (R,S)-3-[4-(9-benzylpurin-6-yl) phenyl]-2-[(t-butoxycarbonyl) amino]propanoate is produced by making 9-benzyl-6-iodopurine react with methyl (R,S)-2-[(t-butoxycarbonyl)amino]-3-[4-(trimethyl-stananyl) phenyl]propionate in the presence of Pd2 dba3, triphenylarsine and copper iodide.Type: ApplicationFiled: March 31, 2004Publication date: June 15, 2006Applicant: USTAV ORGANICKE CHEMIE A BIOCHEMIE AKADEMIE VED CESKE REPUBLIKYInventors: Michal Hocek, Petr Capek