Patents by Inventor Michal Linial

Michal Linial has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Immune disease medicament comprising a modulator of the binding between a heparin binding domain of thrombospondin-1 and a beta1 integrin
    Patent number: 8617561
    Abstract: An article of manufacture comprising packaging material and a pharmaceutical composition is disclosed, the article of manufacture being identified in print in or on the packaging material for treatment of an immunity-related disease in a subject in need thereof. The pharmaceutical composition comprises a pharmaceutically acceptable carrier and, as an active ingredient, a compound being capable of modulating an interaction between a heparin-binding domain of a thrombospondin and a receptor of the heparin-binding domain.
    Type: Grant
    Filed: June 20, 2006
    Date of Patent: December 31, 2013
    Assignees: Hadasit Medical Research Services and Development Ltd., Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventors: Dror Mevorach, Alon Krispin, Yaniv Bledi, Michal Linial
  • Immune Disease Medicament Comprising a Modulator of the Binding Between a Heparin Bindin Domain of Thrombospondin-1 and a Beta1 Integrin
    Publication number: 20100255003
    Abstract: An article of manufacture comprising packaging material and a pharmaceutical composition is disclosed, the article of manufacture being identified in print in or on the packaging material for treatment of an immunity-related disease in a subject in need thereof. The pharmaceutical composition comprises a pharmaceutically acceptable carrier and, as an active ingredient, a compound being capable of modulating an interaction between a heparin-binding domain of a thrombospondin and a receptor of the heparin-binding domain.
    Type: Application
    Filed: June 20, 2006
    Publication date: October 7, 2010
    Applicants: Hadasit Medical Research Services and Development, Yissum Research Development of the Hebrew University of Jerusalem
    Inventors: Dror Mevorach, Alon Krispin, Yaniv Bledi, Michal Linial
  • Toxin-Like Polypeptides, Polynucleotides Encoding Same and Uses Thereof
    Publication number: 20090305970
    Abstract: An isolated polynucleotide is disclosed comprising a nucleic acid sequence encoding a polypeptide which comprises an amino acid sequence at least 90% identical to a sequence as set forth in SEQ ID NO: 1, wherein the polypeptide comprises an ion channel modulatory activity. Polypeptides and uses thereof are also disclosed.
    Type: Application
    Filed: December 12, 2006
    Publication date: December 10, 2009
    Inventors: Michal Linial, Alex Inberg, Noam Kaplan
  • Method and system useful for structural classification of unknown polypeptides
    Publication number: 20040014944
    Abstract: A method of identifying a polypeptide candidate most likely to have undefined structural/functional elements is provided. The method is effected by (a) classifying each cluster of a database of non-structurally clustered polypeptide clusters as: (i) a first cluster, if it includes at least one structurally defined polypeptide; or (ii) a second cluster, if it is devoid of structurally defined polypeptides; (b) determining relational distances between at least one first cluster and a plurality of distinct second clusters according to at least one criteria; and (c) identifying second clusters of the plurality of distinct second clusters which exhibit a relational distance from the at least one first cluster which is greater than a predetermined threshold, thereby identifying the polypeptide candidate most likely to have undefined structural/functional elements.
    Type: Application
    Filed: April 22, 2003
    Publication date: January 22, 2004
    Inventors: Michal Linial, Elon Portugaly