Patents by Inventor Michal Minczuk

Michal Minczuk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF OPTIMISING EXPRESSION AND DELIVERY OF MITOCHONDRIAL PROTEINS
    Publication number: 20220340930
    Abstract: The invention relates to methods for the simultaneous expression and delivery to mitochondria of two or more proteins using a single expression vector. Also described are the expression vectors and host cells comprising the vectors. Where the proteins are genome editing reagents, the invention also relates to the use of the expression vectors to alter levels of mitochondrial heteroplasmy and treat mitochondrial disorders.
    Type: Application
    Filed: March 21, 2019
    Publication date: October 27, 2022
    Inventors: Michal Minczuk, Payam Gammage
  • GENETIC MODIFICATION OF MITOCHONDRIAL GENOMES
    Publication number: 20210002670
    Abstract: The present disclosure is in the field of genome engineering, particularly targeted genetic modification of mitochondrial DNA (mtDNA).
    Type: Application
    Filed: March 21, 2019
    Publication date: January 7, 2021
    Inventors: Michal Minczuk, Lei Zhang, Payam A. Gammage
  • Polypeptide targeting to mitochondria
    Patent number: 10596227
    Abstract: Methods for delivering non-mitochondrial proteins to mitochondria are provided. Also provided are nucleic acid constructs comprising a coding sequence encoding a DNA-binding polypeptide, fused to a mitochondrial targeting sequence (MTS) and a nuclear export signal (NES), and the encoded proteins. The construct successfully delivers DNA binding proteins to the mitochondrion. A chimeric methylase based on the above construct is successfully delivered to mitochondria, resulting in modification of mtDNA.
    Type: Grant
    Filed: September 21, 2015
    Date of Patent: March 24, 2020
    Assignee: United Kingdom Research and Innovation
    Inventors: Michal Minczuk, Monika A. Papworth, Aaron Klug
  • POLYPEPTIDE TARGETING TO MITOCHONDRIA
    Publication number: 20160199443
    Abstract: Methods for delivering non-mitochondrial proteins to mitochondria are provided. Also provided are nucleic acid constructs comprising a coding sequence encoding a DNA-binding polypeptide, fused to a mitochondrial targeting sequence (MTS) and a nuclear export signal (NES), and the encoded proteins. The construct successfully delivers DNA binding proteins to the mitochondrion. A chimeric methylase based on the above construct is successfully delivered to mitochondria, resulting in modification of mtDNA.
    Type: Application
    Filed: September 21, 2015
    Publication date: July 14, 2016
    Inventors: Michal Minczuk, Monika A. Papworth, Aaron Klug
  • Polypeptide targeting to mitochondria
    Patent number: 9139628
    Abstract: Methods for delivering non-mitochondrial proteins to mitochondria are provided. Also provided are nucleic acid constructs comprising a coding sequence encoding a DNA-binding polypeptide, fused to a mitochondrial targeting sequence (MTS) and a nuclear export signal (NES), and the encoded proteins. The construct successfully delivers DNA binding proteins to the mitochondrion. A chimeric methylase based on the above construct is successfully delivered to mitochondria, resulting in modification of mtDNA.
    Type: Grant
    Filed: June 23, 2008
    Date of Patent: September 22, 2015
    Assignee: Medical Research Council
    Inventors: Michal Minczuk, Monika A. Papworth, Aaron Klug
  • POLYPEPTIDE TARGETING TO MITOCHONDRIA
    Publication number: 20090186816
    Abstract: Methods for delivering non-mitochondrial proteins to mitochondria are provided. Also provided are nucleic acid constructs comprising a coding sequence encoding a DNA-binding polypeptide, fused to a mitochondrial targeting sequence (MTS) and a nuclear export signal (NES), and the encoded proteins. The construct successfully delivers DNA binding proteins to the mitochondrion. A chimeric methylase based on the above construct is successfully delivered to mitochondria, resulting in modification of mtDNA.
    Type: Application
    Filed: June 23, 2008
    Publication date: July 23, 2009
    Inventors: Michal Minczuk, Monika A. Papworth, Aaron Klug