Patents by Inventor Michal Rafilovich

Michal Rafilovich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystalline forms of tigecycline and processes for preparation thereof
    Patent number: 8198469
    Abstract: The present invention provides crystalline forms of Tigecycline, and methods of for preparation of crystalline forms and amorphous.
    Type: Grant
    Filed: November 29, 2007
    Date of Patent: June 12, 2012
    Assignee: Teva Pharmaceutical Industries Ltd.
    Inventors: Evgeny Tsiperman, Sofia Gorohovsky-Rosenberg, Slavik Yurkovski, Sergei Fine, Tamás Koltai, Sigalit Levi, Leonid Metsger, Michal Rafilovich
  • Crystalline form II of tigecycline and processes for preparation thereof
    Patent number: 8198470
    Abstract: The present invention provides processes for the preparation of crystalline forms of Tigecycline.
    Type: Grant
    Filed: December 1, 2008
    Date of Patent: June 12, 2012
    Assignee: Teva Pharmaceutical Industries Ltd.
    Inventors: Sigalit Levi, Michal Rafilovich, Sofia Gorohovsky-Rosenberg, Slavik Yurkovski, Sergei Fine, Leonid Metsger, Evgeny Tsiperman
  • Process for the synthesis of ramelteon and its intermediates
    Patent number: 8084630
    Abstract: The present invention provides processes and intermediates for the synthesis of ramelteon.
    Type: Grant
    Filed: June 2, 2008
    Date of Patent: December 27, 2011
    Assignee: Teva Pharmaceutical Industries Ltd.
    Inventors: Vinod Kumar Kansal, Dhirenkumar N. Mistry, Sanjay L. Vasoya, Michal Rafilovich, Elena Ben Moha-Lerman, Revital Lifshitz-Liron
  • Carvedilol phosphate
    Patent number: 8022094
    Abstract: The invention encompasses novel amorphous and crystalline forms of carvedilol phosphate, carvedilol hydrogen phosphate, and carvedilol dihydrogen phosphate as well as methods of making the novel amorphous and crystalline forms. Also disclosed are pharmaceutical compositions comprising the novel amorphous and crystalline forms and uses thereof.
    Type: Grant
    Filed: June 28, 2007
    Date of Patent: September 20, 2011
    Assignee: Teva Pharmaceutical Industries Ltd.
    Inventors: Santiago Ini, Sigalit Levi, Michal Rafilovich, Judith Aronhime, Mili Abramov, Ron Bar-Shavit, Eran Turgeman
  • CRYSTALLINE FORM II OF TIGECYCLINE AND PROCESSES FOR PREPARATION THEREOF
    Publication number: 20100152142
    Abstract: The present invention provides processes for the preparation of crystalline forms of Tigecycline.
    Type: Application
    Filed: December 1, 2008
    Publication date: June 17, 2010
    Inventors: Sigalit Levi, Michal Rafilovich, Sofia Gorohovsky-Rosenberg, Slavik Yurkovski, Sergei Fine, Leonid Metsger, Evgeny Tsiperman
  • Polymorphic forms of rosiglitazone hydrobromide and processes for their preparation
    Publication number: 20100056583
    Abstract: The present invention provides crystalline forms of Rosiglitazone hydrobromide, methods of their preparation, as well as pharmaceutical compositions comprising these crystalline forms.
    Type: Application
    Filed: August 21, 2009
    Publication date: March 4, 2010
    Applicants: TEVA PHARMACEUTICAL INDUSTRIES LTD., TEVA PHARMACEUTICALS USA, INC. - for assignment of rights in Barbados
    Inventors: Vinod Kumar Kansal, Harish Ranjan, Sanjay Nayal, Michal Rafilovich
  • Polymorphic forms of ramelteon and processes for preparation thereof
    Publication number: 20090105490
    Abstract: An amorphous form of ramelteon is provided, as well as mixtures of amorphous and crystalline ramelteon. Also provided are methods of preparing amorphous ramelteon and mixtures of amorphous and crystalline ramelteon, pharmaceutical compositions comprising amorphous ramelteon and mixtures of amorphous and crystalline ramelteon, and methods of treatment of insomnia using the compositions of the invention.
    Type: Application
    Filed: July 14, 2008
    Publication date: April 23, 2009
    Inventors: Nurit Perlman, Michal Rafilovich, Rinat Moshkovits-Kaptsan, Elena Ben Moha-Lerman, Revital Lifshitz-Liron
  • Crystalline forms cinacalcet fumarate and cinacalcet succinate and processes for preparation thereof
    Publication number: 20090093652
    Abstract: The present invention provides crystalline forms of Cinacalcet Fumarate and Cinacalcet Succinate, pharmaceutical compositions comprising the crystalline form of Cinacalcet Fumarate and/or the crystalline form of Cinacalcet Succinate, and processes for preparing the crystalline forms of Cinacalcet Fumarate and Cinacalcet Succinate and pharmaceutical compositions comprising the crystalline forms.
    Type: Application
    Filed: August 18, 2008
    Publication date: April 9, 2009
    Inventors: Michal Rafilovich, Amihai Eisenstadt
  • PROCESS FOR THE SYNTHESIS OF RAMELTEON AND ITS INTERMEDIATES
    Publication number: 20090069581
    Abstract: The present invention provides processes and intermediates for the synthesis of ramelteon.
    Type: Application
    Filed: June 2, 2008
    Publication date: March 12, 2009
    Inventors: Vinod Kumar KANSAL, Dhirenkumar N. MISTRY, Sanjay L. VASOYA, Michal RAFILOVICH, Elena Ben LERMAN-MOHA, Revital LIFSHITZ-LIRON
  • Crystalline forms of tigecycline and processes for preparation thereof
    Publication number: 20090005453
    Abstract: The present invention provides crystalline forms of Tigecycline, and methods of for preparation of crystalline forms and amorphous.
    Type: Application
    Filed: November 29, 2007
    Publication date: January 1, 2009
    Inventors: Evgeny Tsiperman, Sofia Gorohovsky-Rosenberg, Slavik Yurkovski, Sergei Fine, Tamas Koltai, Sigalit Levi, Leonid Metsger, Michal Rafilovich
  • Polymorphic forms of rosiglitazone hydrobromide and processes for preparation thereof
    Publication number: 20080176905
    Abstract: The present invention presents crystal forms of Rosiglitazone hydrobromide, denominated Form I and Form II, methods of their preparation, as well as pharmaceutical compositions comprising these crystalline forms.
    Type: Application
    Filed: January 22, 2008
    Publication date: July 24, 2008
    Inventors: Santiago Ini, Kobi Chen, Michal Rafilovich
  • Carvedilol phosphate
    Publication number: 20080125476
    Abstract: The invention encompasses novel amorphous and crystalline forms of carvedilol phosphate, carvedilol hydrogen phosphate, and carvedilol dihydrogen phosphate as well as methods of making the novel amorphous and crystalline forms. Also disclosed are pharmaceutical compositions comprising the novel amorphous and crystalline forms and uses thereof.
    Type: Application
    Filed: June 28, 2007
    Publication date: May 29, 2008
    Inventors: Santiago Ini, Sigalit Levi, Michal Rafilovich, Judith Aronhime, Mili Abramov, Ron Bar-Shavit, Eran Turgeman