Patents by Inventor Michal STAWARSKI

Michal STAWARSKI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Genetically encoded FRET-based MMP-9 activity biosensor and use thereof
    Patent number: 9914955
    Abstract: The present invention relates to a genetically encoded FRET-based biosensor to monitor the activity of matrix metalloproteinase 9 (MMP-9). MMP-9 is an extracellular acting endopeptidase implicated in both physiological and pathological processes. A genetically encoded FRET biosensor anchored in the cellular membrane allows studying the proteolytic activity of MMP-9 with high spatiotemporal resolution at the exact region of MMP-9 action on the cell. Applicability of the biosensor, both in vitro and in vivo in living cells, has been demonstrated by ratiometric analysis of cleavage of the biosensor by a purified auto-activating mutant of MMP-9.
    Type: Grant
    Filed: August 12, 2014
    Date of Patent: March 13, 2018
    Assignee: Instytut Biologii Doświadczalnej im. Marcelego Nenckiego Polska Akademia Nauk
    Inventors: Michal Stawarski, Jakub Wlodarczyk, Leszek Kaczmarek
  • Genetically encoded FRET-based MMP-9 activity biosensor and use thereof
    Publication number: 20160194681
    Abstract: The present invention relates to a genetically encoded FRET-based biosensor to monitor the activity of matrix metalloproteinase 9 (MMP-9). MMP-9 is an extracellular acting endopeptidase implicated in both physiological and pathological processes. A genetically encoded FRET biosensor anchored in the cellular membrane allows studying the proteolytic activity of MMP-9 with high spatiotemporal resolution at the exact region of MMP-9 action on the cell. Applicability of the biosensor, both in vitro and in vivo in living cells, has been demonstrated by ratiometric analysis of cleavage of the biosensor by a purified auto-activating mutant of MMP-9.
    Type: Application
    Filed: August 12, 2014
    Publication date: July 7, 2016
    Applicant: Instytut Biologii Doswiadczainej im. Marcelego Nenckiego Polska Akademia Nauk
    Inventors: Michal STAWARSKI, Jakub WLODARCZYK, Leszek KACZMAREK