Abstract: The present disclosure provides substituted imidazo[1,5-a]pyridine N-heterocyclic carbene (NHC) ligands, catalyst complexes thereof, and methods using same. The present disclosure further provides synthetic methods of preparing N-heterocyclic carbene ligands and catalyst complexes thereof.

Abstract: The present disclosure provides N-heterocyclic carbene ligands, catalyst complexes thereof, and methods using same. The present disclosure further provides synthetic methods of preparing the N-heterocyclic carbene ligands and catalyst complexes disclosed herein.

Abstract: The present disclosure relates in part to novel complexes of unsymmetrical N-heterocylic carbene (NHC) ligands and group 10 or 11 metals. The present disclosure further relates to methods of electrophilic functionalization of alkynes and/or nitriles using the NHC catalysts described herein.

Abstract: The present disclosure relates in part to sterically hindered N-aliphatic N-heterocyclic carbene (NHC) ligands, which are readily synthetically available from inexpensive starting materials. The present disclosure further relates to NHC catalyst complexes comprising transition metals such as Cu, Ag, Au, and Pd. Furthermore, the present disclosure provides methods for using the catalysts described herein in a number of organic transformations, including alkyne hydroboration and hydration, in addition to C—O, C—C, and C—N coupling reactions.

Abstract: The present disclosure provides, in part, a new class of highly active Pd(II)-NHC complexes bearing anilines as throw-away ligands. These catalysts are well-defined, air- and moisture-stable, and can be easily purified by chromatographic techniques. High activity and generality has been exemplified in the Suzuki-Miyaura cross-coupling by C—N, C—O and C—Cl cleavage. Facile syntheses of these catalysts is also described.

Abstract: Provided herein, in part, is a new class of sterically bulky, easily prepared N-heterocyclic carbene (NHC) ligands of Formula I, or a salt, solvate, geometric isomer, or stereoisomer thereof. The ligands are readily synthetically accessible exploiting the cost-effective, modular alkylation of anilines. The NHC ligands of the present disclosure can be used to prepare effective catalysts with transition metals, including the compound of Formula II, or a salt, solvate, geometric isomer, or stereoisomer thereof. In certain embodiments, the transition metal is Pd.