Patents by Inventor Michal Weinstock

Michal Weinstock has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11879898
    Abstract: The teachings herein provide for a method of analyzing testosterone using mass spectrometry. The method entails combining in a vial or well, a tagging reagent that is reactive with testosterone, an aqueous precipitation agent that precipitate proteins from solution, and an internal standard solution, the internal standard solution containing a known concentration of an isotopically enriched testosterone and then adding to the vial or well, a sample containing or suspected to contain testosterone. The vial can then be mixed to cause simultaneous precipitation of proteins and reaction of any testosterone present with the tagging reagent to form a mixture of a precipitate and a liquid solution. The liquid solution can then be separated from any precipitate and then analyzed for testosterone using liquid chromatography tandem mass spectrometry.
    Type: Grant
    Filed: December 23, 2019
    Date of Patent: January 23, 2024
    Assignee: DH Technologies Development Pte. Ltd.
    Inventors: Subhakar N Dey, Michal Weinstock
  • Publication number: 20220057412
    Abstract: The teachings herein provide for a method of analyzing testosterone using mass spectrometry. The method entails combining in a vial or well, a tagging reagent that is reactive with testosterone, an aqueous precipitation agent that precipitate proteins from solution, and an internal standard solution, the internal standard solution containing a known concentration of an isotopically enriched testosterone and then adding to the vial or well, a sample containing or suspected to contain testosterone. The vial can then be mixed to cause simultaneous precipitation of proteins and reaction of any testosterone present with the tagging reagent to form a mixture of a precipitate and a liquid solution. The liquid solution can then be separated from any precipitate and then analyzed for testosterone using liquid chromatography tandem mass spectrometry.
    Type: Application
    Filed: December 23, 2019
    Publication date: February 24, 2022
    Inventors: Subhakar N Dey, Michal Weinstock
  • Patent number: 10094809
    Abstract: Labeling reagents, sets of labeling reagents, and labeling techniques are provided for the relative quantitation, absolute quantitation, or both, of ketone or aldehyde compounds including, but not limited to, analytes comprising steroids or ketosteroids and includes testosterone. The analytes can be medical or pharmaceutical compounds in biological samples. Methods for labeling, analyzing, and quantifying ketone or aldehyde compounds are also disclosed as are methods that also use mass spectrometry.
    Type: Grant
    Filed: October 31, 2016
    Date of Patent: October 9, 2018
    Assignee: DH Technologies Development Pte. Ltd.
    Inventors: Subhakar Dey, Sasi Pillai, Brian L. Williamson, Subhasish Purkayastha, Michal Weinstock
  • Patent number: 10078091
    Abstract: A method, a labeling reagent, sets of labeling reagents, and labeling techniques are provided for the analysis of ketosterol biomarkers such as bile acid precursors from human plasma, serum or whole blood. This method is used for new born screening for Cerebrotendinous Xanthomatosis (CTX). Methods for labeling, analyzing, and quantifying ketosterol biomarkers are also disclosed as are methods that also use mass spectrometry.
    Type: Grant
    Filed: May 17, 2013
    Date of Patent: September 18, 2018
    Assignees: DH Technologies Development Pte. Ltd., Oregon Health and Science University
    Inventors: Andrea DeBarber, Subhasish Purkayastha, Robert D. Steiner, Michal Weinstock
  • Publication number: 20170115258
    Abstract: Labeling reagents, sets of labeling reagents, and labeling techniques are provided for the relative quantitation, absolute quantitation, or both, of ketone or aldehyde compounds including, but not limited to, analytes comprising steroids or ketosteroids and includes testosterone. The analytes can be medical or pharmaceutical compounds in biological samples. Methods for labeling, analyzing, and quantifying ketone or aldehyde compounds are also disclosed as are methods that also use mass spectrometry.
    Type: Application
    Filed: October 31, 2016
    Publication date: April 27, 2017
    Inventors: Subhakar Dey, Sasi Pillai, Brian L. Williamson, Subhasish Purkayastha, Michal Weinstock
  • Patent number: 9500622
    Abstract: Labeling reagents, sets of labeling reagents, and labeling techniques are provided for the relative quantitation, absolute quantitation, or both, of ketone or aldehyde compounds including, but not limited to, analytes comprising steroids or ketosteroids. The analytes can be medical or pharmaceutical compounds in biological samples. Methods for labeling, analyzing, and quantifying ketone or aldehyde compounds are also disclosed as are methods that also use mass spectrometry.
    Type: Grant
    Filed: May 20, 2013
    Date of Patent: November 22, 2016
    Assignee: DH Technologies Development Pte. Ltd.
    Inventors: Subhakar Dey, Sasi Pillal, Brian L. Williamson, Subhasish Purkayastha, Michal Weinstock
  • Publication number: 20150323554
    Abstract: A method, a labeling reagent, sets of labeling reagents, and labeling techniques are provided for the analysis of ketosterol biomarkers such as bile acid precursors from human plasma, serum or whole blood. This method is used for new born screening for Cerebrotendinous Xanthomatosis (CTX). Methods for labeling, analyzing, and quantifying ketosterol biomarkers are also disclosed as are methods that also use mass spectrometry.
    Type: Application
    Filed: May 17, 2013
    Publication date: November 12, 2015
    Applicant: DH Technologies Development Pte. Ltd
    Inventors: Andrea DeBarber, Subhasish Purkayastha, Robert D. Steiner, Michal Weinstock
  • Publication number: 20140004616
    Abstract: Labeling reagents, sets of labeling reagents, and labeling techniques are provided for the relative quantitation, absolute quantitation, or both, of ketone or aldehyde compounds including, but not limited to, analytes comprising steroids or ketosteroids. The analytes can be medical or pharmaceutical compounds in biological samples. Methods for labeling, analyzing, and quantifying ketone or aldehyde compounds are also disclosed as are methods that also use mass spectrometry.
    Type: Application
    Filed: May 20, 2013
    Publication date: January 2, 2014
    Applicant: DH Technologies Development Pte. Ltd.
    Inventors: Subhakar Dey, Sasi Pillal, Brian L. Williamson, Subhasish Purkayastha, Michal Weinstock
  • Publication number: 20110003395
    Abstract: Labeling reagents, sets of labeling reagents, and labeling techniques are provided for the relative quantitation, absolute quantitation, or both, of ketone or aldehyde compounds including, but not limited to, analytes comprising steroids or ketosteroids. The analytes can be medical or pharmaceutical compounds in biological samples. Methods for labeling, analyzing, and quantifying ketone or aldehyde compounds are also disclosed as are methods that also use mass spectrometry.
    Type: Application
    Filed: June 1, 2010
    Publication date: January 6, 2011
    Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
    Inventors: Subhakar DEY, Sasi PILLAI, Brian L. WILLIAMSON, Subhasish PURKAYASTHA, Michal Weinstock