Abstract: The present invention discloses series formulas that can calculate various pharmacokinetic parameters upon administration of multiple maintenance doses and a method to custom-build series equations for dosage regimens that include administration of other doses in addition to the maintenance doses via different routes of administration as a function of dose number and total time in the one- and two-compartment pharmacokinetic models. These series formulas, when compared to the old traditional equations that relate drug concentration to the “dummy” time variable of dosing interval, are ideal for studying time-dependent pharmacokinetic parameters such as the peak time (tmax) after multiple extravascular dosages and they offer an alternative elegant way of writing algorithms for calculating and plotting pharmacokinetic parameters as a function of total time.

Abstract: The present invention relates to the discovery of the apparent volume of distribution as an intensive physical property of matter and its use in the field of chemical separation sciences and pharmacokinetics. The invention provides various methods of determining the amount of substance in all phases, substance concentration in all phases, extraction efficiency, solvent capacity, phase volume needed to achieve a given extraction efficiency, the substance's apparent volumes of distribution with respect to each phase in the system and the partition coefficient or distribution ratio that defines the partitioning of the substance between two phases that are in contact. In the field of pharmacokinetic multiphasic compartment models the invention provides methods to determine the substance amount in the body from measured plasma substance concentration at all times in the one-compartment model and at times of momentary distribution equilibrium of the substance (teq) in multi-compartment models.

Abstract: The present invention discloses a computer program and a method including an algorithm for computing the uncertainty of drug concentration in pharmaceutical dosage forms. The invention also provides a computer system, a website and an IC chip incorporating the program product. The invention determines the allowable sensitivity of the instruments measuring each of the components and the least allowable weight (LAW) within a maximum allowable error of each ingredient at the predetermined assay standard. The method and products allow the accurate error evaluation of drug dose in pharmaceutical mixtures and unit dosage forms, which may be composed of an infinite number of ingredients that are measured on multiple equipments of variable sensitivities. Thus this invention provides instant guidance on the pharmaceutical ingredient preparation.

Abstract: The present invention discloses a computer program and a method including an algorithm for computing the uncertainty of drug concentration in pharmaceutical dosage forms. The invention also provides a computer system, a website and an IC chip incorporating the program product. The invention determines the allowable sensitivity of the instruments measuring each of the components and the least allowable weight (LAW) within a maximum allowable error of each ingredient at the predetermined assay standard. The method and products allow the accurate error evaluation of drug dose in pharmaceutical mixtures and unit dosage forms, which may be composed of an infinite number of ingredients that are measured on multiple equipments of variable sensitivities. Thus this invention provides instant guidance on the pharmaceutical ingredient preparation.

Abstract: The current invention relates to the synthesis of novel cationic lipids and their use as delivery vectors for nucleic acids, peptides and other synthetic drugs, in vitro and in vivo. The cationic lipids described herein form stable lamellar structures (liposomes) at physiological pH but destabilize to micelles at acidic and alkaline pH. These structures are characterized of high elasticity, increased fluidity and high transfection activity relative to the corresponding 1,2-dialkyl cationic derivatives and other phospholipids analogues.

Abstract: The invention describes the synthetic methods for a series of pH-sensitive cationic lipids with diamido linkages between the 1,2-diamino-3-propanol backbone and the hydrocarbon chains. Their in vitro biological activity of the resulting lipid-DNA complexes is also described.