Patents by Inventor Michao SHI

Michao SHI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystal of cephalosporin intermediate 7?-methoxy cephalothin and method for preparing same
    Patent number: 11053259
    Abstract: The present invention relates to a crystal of cephalosporin intermediate 7?-methoxy cephalothin (I) and a method for preparing same. The crystal of 7?-methoxy cephalothin (I) undergoes Cu-Ka radiation and X-ray powder diffraction expressed in terms of angle 2?; the crystal of 7?-methoxy cephalothin (I) has characteristic absorption peaks at positions of 7.34°±0.20°, 12.71°±0.20°, 14.25°±0.20°, 14.68°±0.20°, 16.52°±0.20°, 17.99°±0.20°, 19.98°±0.20°, and 22.69°±0.20°. The crystal of 7?-methoxy cephalothin provided by the present invention is easy to prepare. Related test data shows that the crystal of 7?-methoxy cephalothin has high purity, low impurity content, and good stability. The preparation cost is low, the preparation method is simple to operate, conditions are mild and easy to control, and crystals of 7?-methoxy cephalothin can be obtained stably. The invention is applicable to industrial production.
    Type: Grant
    Filed: February 23, 2018
    Date of Patent: July 6, 2021
    Assignee: QILU ANTIBIOTICS PHARMACEUTICAL CO. LTD.
    Inventors: Chuanshan Hou, Fei Tang, Meiju Fan, Xin Wang, Jinglong Fu, Michao Shi, Xi Lei, Hongmei Xu
  • CRYSTAL OF CEPHALOSPORIN INTERMEDIATE 7alpha-METHOXY CEPHALOTHIN AND METHOD FOR PREPARING SAME
    Publication number: 20200131197
    Abstract: The present invention relates to a crystal of cephalosporin intermediate 7?-methoxy cephalothin (I) and a method for preparing same. The crystal of 7?-methoxy cephalothin (I) undergoes Cu-Ka radiation and X-ray powder diffraction expressed in terms of angle 2?; the crystal of 7?-methoxy cephalothin (I) has characteristic absorption peaks at positions of 7.34°±0.20°, 12.71°±0.20°, 14.25°±0.20°, 14.68°±0.20°, 16.52°±0.20°, 17.99°±0.20°, 19.98°±0.20°, and 22.69°±0.20°. The crystal of 7?-methoxy cephalothin provided by the present invention is easy to prepare. Related test data shows that the crystal of 7?-methoxy cephalothin has high purity, low impurity content, and good stability. The preparation cost is low, the preparation method is simple to operate, conditions are mild and easy to control, and crystals of 7?-methoxy cephalothin can be obtained stably. The invention is applicable to industrial production.
    Type: Application
    Filed: February 23, 2018
    Publication date: April 30, 2020
    Inventors: Chuanshan HOU, Fei TANG, Meiju FAN, Xin WANG, Jinglong FU, Michao SHI, Xi LEI, Hongmei XU