Abstract: The invention relates to anti-VEGF polypeptides and antibody single variable domains (dAbs) that are resistant to degradation by a protease, as well as antagonists comprising these. The polypeptides, dAbs and antagonists are useful for pulmonary administration, oral administration, delivery to the lung and delivery to the GI tract of a patient, as well as for treating cancer and inflammatory disease, such as arthritis.

Abstract: A hoof pad for treatment of equine lower limb pathology comprising, a pad formed of rigid material having an upper hoof contacting surface spaced apart from a lower flat surface that is adapted for ground contact or for mounting of a supplemental pad, the anterior, posterior, medial and lateral side surfaces being sloped and curvilinearly interconnected and where the anterior and posterior side surfaces have a lesser slope than the medial and lateral side surfaces, said pad having a plan view shape substantially similar to that of the ground contacting surface of a horse's hoof, but laterally wider.