Abstract: This application relates to an incubation device for serology or histology supports. It also relates to any apparatus comprising one such device, and to the use of said apparatuses and/or devices in analysis or diagnosis methods.

Abstract: Methods and equipment for forming multiple micro-depositions on surfaces from a single sample for sample analysis are provided. The device for the formation of micro-depositions of a liquid sample, includes a plurality of reservoirs, each with a through-hole, and needles, each with a tip mounted for movement through and beyond the hole, and a control member ensuring the controlled and regular formation of micro-depositions according to a defined profile.

Abstract: A method for reading slides bearing fluorescent deposits, such as used in serology or molecular biology analysis, includes: incubating a slide with a sample of serum from a patient, or a dilution thereof, and revealing antibodies in the sample bound to the deposits by labelled reagents. Label reading and analysis is performed by a device including a slide positioner, light emitting diodes arranged in illumination channels to provide oblique illumination at different wave lengths, and a collection optic for forming an image of the deposits on a sensor.

Abstract: This application relates to an incubation device for serology or histology supports. It also relates to any apparatus comprising one such device, and to the use of said apparatuses and/or devices in analysis or diagnosis methods.

Abstract: The invention concerns methods and devices for observing or analysing samples on a support. More particularly, it concerns a device for sequential observation of several samples arranged on a common plate (19) comprising an objective (15) for observing a stage (17) for positioning the plate (19) adapted to ensure a relative displacement between the plate (19) and the observation axis in a plane perpendicular to the observation axis, while leaving free the vertical displacement along the observation axis, means (21) for illuminating the sample and means (23, 25) for acquiring an image at the objective (15) output.

Abstract: The invention concerns a device for reading slides bearing fluorescent deposits, such as used in serology or molecular biology analysis. The invention also concerns any apparatus comprising such a device, specific implementing software, as well as the use of said apparatuses and/or devices in analytical or diagnostic methods.

Abstract: The invention concerns a method for detecting or quantifying eosinophils and basophils, which consists in contacting a sample possibly containing said eosinophils or basophils with an IL-5 anti-receptor (alpha-chain) monoclonal antibody which does not interfere with IL-5 fixation to its receptor and does not inhibit the IL-5 biological activity to detect and, if required to quantify eosinophils and basphils. The invention also concerns a kit for detecting or quantifying eosinophils or basophils and an anti-IL5R antibody.

Abstract: The invention relates to a device for positioning a biological sample analysis plate on an observation device comprising an observation lens and a chassis having a plate support assembly [20]. This assembly comprises a first frame [21] and a second frame [22] able to slide in a plane perpendicular to the observation axis, assumed to be vertical, with the first and second frames each able to move in a direction perpendicular to the direction of movement of the other frame; and a third frame [23] supported by the second frame [22] by means [30] used to maintain said third frame in a plane perpendicular to the observation axis, while leaving the movement free in a vertical plane.

Abstract: An optical device (12) includes a front surface located on the side of the sample to be observed and a rear surface oriented towards the elements for acquiring (18, 19) an image or a user. It further includes a combination of four aligned lenses. The lenses are arranged in the following sequence from the front rearwards: a plano-convex lens (28), a convexo-concave lens (30), a plano-concave lens (32) and a biconvex lens (34). The plano-concave (32) and the plano-convex lenses are respectively such that they each have a substantially planar surface and a concave surface or convex surface respectively. The invention is applicable to a cell analyzer.

Abstract: The present invention relates to compositions and methods for screening and/or identifying compounds exhibiting biological activity on neurons. The invention also relates to the isolation and culture of neurons, methods of inducing pathological conditions to said isolated neurons, as well as kits for implementing said methods. The invention can be used in experimental research, drug discovery, drug development, and the like. More particularly, the invention can be used to identify and/or characterize and/or improve compounds which are active on neurons and can be used for treating disorders of the nervous system.

Abstract: The invention relates to a device for positioning a biological sample analysis plate on an observation device comprising an observation lens and a chassis having a plate support assembly [20]. This assembly comprises a first frame [21] and a second frame [22] able to slide in a plane perpendicular to the observation axis, assumed to be vertical, with the first and second frames each able to move in a direction perpendicular to the direction of movement of the other frame; and a third frame [23] supported by the second frame [22] by means [30] used to maintain said third frame in a plane perpendicular to the observation axis, while leaving the movement free in a vertical plane.

Abstract: The invention concerns methods and devices for observing or analysing samples on a support. More particularly, it concerns a device for sequential observation of several samples arranged on a common plate (19) comprising an objective (15) for observing a stage (17) for positioning the plate (19) adapted to ensure a relative displacement between the plate (19) and the observation axis in a plane perpendicular to the observation axis, while leaving free the vertical displacement along the observation axis, means (21) for illuminating the sample and means (23, 25) for acquiring an image at the objective (15) output. It comprises a spacer (43) fixed relative to the objective (15) and having a support surface (45) on the support (19), said support surface being located proximate to the observation axis, so that said spacer (43) is adapted to maintain, on the observation axis, a constant distance between the objective (15) support (19) and the observation axis.

Abstract: The present invention relates to compositions and methods for screening and/or identifying compounds exhibiting biological activity on neurons. The invention also relates to the isolation and culture of neurons, methods of inducing pathological conditions to said isolated neurons, as well as kits for implementing said methods. The invention can be used in experimental research, drug discovery, drug development, and the like. More particularly, the invention can be used to identify and/or characterize and/or improve compounds which are active on neurons and can be used for treating disorders of the nervous system.

Abstract: A liquid pharmaceutical formulation for administration by the oro-mucosal route, comprising at least one non-polypeptidic active substance and less than 5% W/W of capryl caproyl macrogol glycerides, process for its preparation and it uses.

Abstract: Process for the identification or determination of proteins by producing antibodies with the aid of peptides that are made immunogenic if necessary, and then using the resulting antibodies to determine the proteins of interest, starting with a sample that contains these and which is treated to liberate the said peptides, in which process the said peptide is so chosen that it matches a known amino acid sequence of the said protein and is used as a protein fragment that the protein can be made to release on enzymatic treatment, after which it is synthesized, the invention also relating to the applications of this process for the identification or the determination of proteins.

Abstract: Derivatives of biologically active molecules containing a primary amine group and a hydroxylated nucleus, and their addition salts with mineral or organic acids, having general formula I:R'R"N--A--B--O--CH.sub.2 --CO--NH--R (I)A=linear or branched C.sub.1 -C.sub.5 alkylene;B=C.sub.4 -C.sub.10 aromatic nucleus with optional heteroatom, or=group --B.sub.1 --X--B.sub.2 --, wherein X=O or C.sub.1 -C.sub.4 alkylene;--NH--R=amine residue or alcohol residue; andR', R"=C.sub.1 -C.sub.5 alkyl, H or hydrophobic radical, and their addition salts with mineral or organic acids, method of preparation, applications, especially to visualization, purification, the preparation of antibodies and the assay of the total hormone, and as drugs, compositions in which they are present and analytical kits.

Abstract: Derivatives comprising two hydrophilic haptens and an effector group comprising a radioactive isotope or known to be able to be labelled by a radioactive isotope or comprising an active principle or known to be able to bind an active principle, linked by a connecting bridge application to diagnosis and to therapeutics, diagnostic or therapeutic kits and immunological reagents containing them.

Abstract: Immunological reagents, consisting of a) antibody or fragment conjugates having both an anti-cell specificity and an anti-hapten specificity, and b) synthetic tracers containing at least two hapten sites and at least one site suitable to attach radioactive isotopes, paramagnetic ions, drugs or toxins, are provided. These reagents are capable of binding to target cells in a specific way, and the tracer localizes preferentially on the membrane of antigen-bearing cells, even in the presence of excess antibody conjugate (affinity enhancement). These reagents are usefully employed, either in vitro or in vivo, to detect tumors, metastases, or other tissue injuries, when the synthetic tracer carries radioactive or paramagnetic compounds, and to kill target cells when the synthetic tracer carries radioactive compounds or drugs or toxins.

Abstract: The invention relates to a product to permit separation of cells in the domain of immunopurification and consisting of a finely divided carrier of a density lower than that of the medium from which such cells must be extracted, such carrier being covered with macromolecules capable of being specifically fixed to the cells to be extracted to which a priviliged orientation was given to enable fixation of such macromolecules.

Abstract: The invention relates to a product to permit separation of cells in the domain of immunopurification and consisting of a finely divided carrier of a density lower than that of the medium from which such cells must be extracted, such carrier being covered with macromolecules capable of being specifically fixed to the cells to be extracted to which a privileged orientation was given to enable fixation of such macromolecules.