Patents by Inventor Michel Detheux

Michel Detheux has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Organic compounds
    Patent number: 10203327
    Abstract: The present invention relates to modulators of the interaction between G-protein coupled receptor 15(GPR15) and c10orf99. The modulator may be a small chemical molecule, antibody or other therapeutic protein. Methods of medical treatment and methods of identifying modulators are also described.
    Type: Grant
    Filed: October 23, 2014
    Date of Patent: February 12, 2019
    Assignees: Novartis AG, Odega S.A.
    Inventors: Frederic Bassilana, Birgit Uta Baumgarten, Nathalie Marie-Therese Carte, Michel Detheux, Rocco Falchetto, Sebastien Hannedouche, Vincent Lannoy, Keith Mansfield, Klaus Peter Seuwen, Thomas Laurent Henri Suply
  • ORGANIC COMPOUNDS
    Publication number: 20160274110
    Abstract: The present invention relates to modulators of the interaction between G-protein coupled receptor 15(GPR15) and c10orf99. The modulator maybe a small chemical molecule, antibody or other therapeutic protein. Methods of medical treatment and methods of identifying modulators are also described.
    Type: Application
    Filed: October 23, 2014
    Publication date: September 22, 2016
    Applicants: NOVARTIS AG, EUROSCREEN S.A.
    Inventors: Frederic BASSILANA, Birgit Uta BAUMGARTEN, Nathalie Marie-Therese CARTE, Michel DETHEUX, Rocco FALCHETTO, Sebastien HANNEDOUCHE, Vincent LANNOY, Keith MANSFIELD, Klaus Peter SEUWEN, Thomas Laurent Henri Suply
  • Methods of making an antibody that binds a chemerin polypeptide
    Patent number: 8030453
    Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
    Type: Grant
    Filed: February 19, 2009
    Date of Patent: October 4, 2011
    Assignee: Euroscreen S.A.
    Inventors: Valerie Wittamer, Jean-Francois Mirjolet, Isabelle Migeotte, David Communi, Alberto Mantovani, Silvano Sozzani, Marisa Vulcano, Jean-Denis Franssen, Stephane Brezillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel Le Poul, Cecile Loison, Frederic Ooms
  • Nucleic acids encoding ChemerinR ligands
    Patent number: 8003347
    Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
    Type: Grant
    Filed: August 1, 2008
    Date of Patent: August 23, 2011
    Assignee: Euroscreen S.A.
    Inventors: Valeria Wittamer, Jean-Francois Mirjolet, Isabelle Migeotte, David Communi, Alberto Mantovani, Silvano Sozzani, Marisa Vulcano, Jean-Denis Franssen, Stephane Brezillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel Lepoul
  • COMPOSITIONS AND METHODS COMPRISING A LIGAND OF CHEMERINR
    Publication number: 20110033467
    Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
    Type: Application
    Filed: February 19, 2009
    Publication date: February 10, 2011
    Inventors: Valerie Wittamer, J. F. Mirjolet, Isabelle Migeotte, David Communi, Alberto Mantovani, Marisa Vulcano, Jean-Denis Franssen, Stephane Brezillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel Le Poul, Cecile Loison, Frederic Ooms, Silvano Sozzani
  • Monoclonal antibodies that bind Chemerin polypeptide
    Patent number: 7858755
    Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
    Type: Grant
    Filed: July 16, 2004
    Date of Patent: December 28, 2010
    Assignee: Euroscreen S.A.
    Inventors: Valerie Wittamer, Jean-François Mirjolet, Isabelle Migeotte, David Communi, Alberto Mantovani, Silvano Sozzani, Marisa Vulcano, Jean-Denis Franssen, Stephane Brezillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel LePoul, Cecile Loison, Frédéric Ooms
  • Methods of identifying modulators of ChemerinR polypeptides
    Patent number: 7842453
    Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
    Type: Grant
    Filed: October 26, 2007
    Date of Patent: November 30, 2010
    Assignee: Euroscreen S.A.
    Inventors: Valeria Wittamer, Jean-François Mirjolet, Isabelle Migeotte, David Communi, Alberto Mantovani, Silvano Sozzani, Marisa Vulcano, Jean-Denis Franseen, Stephane Brezillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel Lepoul
  • COMPOSITIONS AND METHODS COMPRISING A LIGAND OF CHEMERINR
    Publication number: 20100267138
    Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screeing assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
    Type: Application
    Filed: February 19, 2009
    Publication date: October 21, 2010
    Inventors: Valerie Wittamer, J. F. Mirjolet, Isabelle Migeotte, David Communi, Alberto Mantovani, Marisa Vulcano, Jean-Denis Franssen, Stephane Brezillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel Le Poul, Cecile Loison, Frederic Ooms, Silvano Sozzani
  • Compositions comprising a ligand of Chemerin R
    Patent number: 7666401
    Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
    Type: Grant
    Filed: October 30, 2007
    Date of Patent: February 23, 2010
    Assignee: Euroscreen S.A.
    Inventors: Valeria Wittamer, J. F. Mirjolet, Isabelle Migeotte, David Communi, Alberto Mantovani, Silvano Sozzani, Marisa Vulcano, Jean-Denis Franseen, Stephane Brezillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel Lepoul, Cecile Loison, Frederic Ooms
  • Compositions and methods comprising a ligand of chemerin R
    Publication number: 20100009345
    Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screeing assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
    Type: Application
    Filed: October 26, 2007
    Publication date: January 14, 2010
    Inventors: Valeria Wittamer, J.F. Mirjolet, Isabelle Migeotte, Daivd Communi, Alberto Mantovani, Silvano Sozzani, Marisa Vulcano, Jean-Denis Franseen, Stephane Brezillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel Le Poul
  • Functional antibodies that specifically bind to the Chemerin receptor
    Patent number: 7582734
    Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screeing assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
    Type: Grant
    Filed: September 29, 2006
    Date of Patent: September 1, 2009
    Assignee: Euroscreen S.A.
    Inventors: Valeria Wittamer, Jean-François Mirjolet, Isabelle Migeotte, David Communi, Alberto Mantovani, Silvano Sozzani, Marisa Vulcano, Jean-Denis Franseen, Stephane Brezillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel Lepoul, Cecile Loison, Frederic Ooms
  • Processed human chemokines PHC-1 and PHC-2
    Publication number: 20090082262
    Abstract: The present invention is related to newly identified compounds, polynucleotide sequences encoding the amino acid sequences of the compounds, as well as agonists, antagonists or inhibitors of the compounds for chemokine receptors, especially the CCR-5 receptor and their use in the field of diagnostics and therapeutics involving the chemokine receptors.
    Type: Application
    Filed: October 13, 2006
    Publication date: March 26, 2009
    Inventors: Wolf-Georg Forssman, Michel Detheux, Marc Parmentier, Ludger Standker, Frank Kirchhoff
  • Compositions and Methods Comprising a Ligand of ChemerinR
    Publication number: 20090081729
    Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
    Type: Application
    Filed: August 1, 2008
    Publication date: March 26, 2009
    Applicant: Euroscreen S.A.
    Inventors: Valeria Wittamer, Jean-Francois Mirjolet, Isabelle Migeotte, David Communi, Alberto Mantovani, Silvano Sozzani, Marisa Vulcano, Jean-Denis Franseen, Stephane Brezillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel Le Poul
  • Compositions and methods comprising a ligand of chemerin R
    Publication number: 20090047741
    Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
    Type: Application
    Filed: October 30, 2007
    Publication date: February 19, 2009
    Inventors: Valeria Wittamer, J.F. Mirjolet, Isabelle Migeotte, David Communi, Alberto Mantovani, Marisa Vulcano, Jean-Denis Franseen, Stephane Brezillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel Le Poul, Cecile Loison, Frederic Ooms, Silvano Sozzani
  • Antibody that specifically binds to Chemerin receptor ligand precursor
    Patent number: 7470772
    Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
    Type: Grant
    Filed: September 29, 2006
    Date of Patent: December 30, 2008
    Assignee: Euroscreen s.a.
    Inventors: Valeria Wittamer, Jean-Francois Mirjolet, Isabelle Migeotte, David Communi, Alberto Mantovani, Silvano Sozzani, Marisa Vulcano, Jean-Denis Franssen, Stephane Brezillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel Le Poul, Cecile Loison, Frederic Ooms
  • Ligand for G-protein coupled receptor GPR43 and uses thereof
    Publication number: 20080286806
    Abstract: The present invention is related to the G-protein coupled orphan receptor GPR43 and the identification of short chain fatty acids as natural ligands of the receptor. The invention further relates to assays for the identification of agents that modulate GPR43 ligand binding and signalling activity, as well as compositions consisting essentially of an isolated GPR43 polypeptide and an isolated short chain fatty acid. The invention also relates to diagnostic methods and kits that take advantage of the novel interaction of GPR43 with short chain fatty acids.
    Type: Application
    Filed: November 20, 2007
    Publication date: November 20, 2008
    Inventors: Emmanuel LePoul, Michel Detheux, Stephane Brezillon, Vincent Lannoy, Marc Parmentier
  • Natural ligand for orphan G protein coupled receptor GPR86 and methods of use
    Patent number: 7422846
    Abstract: The present invention is related to a method of detecting the dysregulation of GPR86 activity.
    Type: Grant
    Filed: August 31, 2005
    Date of Patent: September 9, 2008
    Assignee: Euroscreen S.A
    Inventors: Didier Communi, Nathalie Suarez, Michel Detheux, Stephane Brezillian, Vincent Lannoy, Marc Parmentier, Jean-Marie Boeynaems
  • Isolated ligand of ChemerinR
    Patent number: 7419658
    Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screeing assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
    Type: Grant
    Filed: June 25, 2003
    Date of Patent: September 2, 2008
    Assignee: Euroscreen s.a.
    Inventors: Valerie Wittamer, Jean-Francois Mirjolet, Isabelle Migeotte, David Communi, Alberto Mantovani, Silvano Sozzani, Marisa Vulcano, Jean-Denis Franssen, Stephane Brezillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel Le Poul
  • Compositions comprising a ligand of chemerinR
    Publication number: 20080125357
    Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
    Type: Application
    Filed: March 13, 2006
    Publication date: May 29, 2008
    Inventors: Valerie Wittamer, J.F. Mirjolet, Isabelle Migeotte, David Communi, Alberto Mantovani, Silvano Sozzani, Marisa Vulcano, Jean-Denis Franssen, Stephane Brezillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel Le Poul
  • Methods of identifying modulators of ligand binding to ChemerinR polypeptides
    Patent number: 7332291
    Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screeing assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
    Type: Grant
    Filed: May 20, 2005
    Date of Patent: February 19, 2008
    Assignee: Euroscreen s.a.
    Inventors: Valérie Wittamer, Jean-Francois Mirjolet, Isabelle Migeotte, David Communi, Alberto Mantovani, Silvano Sozzani, Marisa Vulcano, Jean-Denis Franssen, Stéphane Brézillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel Le Poul