Abstract: A base element for an at least two-part overvoltage protective arrangement, has a support rail receptacle for receiving a support rail carrying an electrical potential, a first receptacle for receiving a first electrical conductor, a second receptacle for receiving a second electrical conductor, and a protective element receptacle for receiving an overvoltage protective element. An electrical connecting element for transmitting an electrical signal from the first receptacle to the second receptacle is produced between the first second receptacles. An electrical support rail contact element makes electrical contact with the support rail when the support rail is received by the support rail receptacle. The first and second receptacles receive electrical connector parts or adapter connector parts for electrical connector parts. An overvoltage protective arrangement with such a base element.

Abstract: The invention relates to a method for detecting the binding of an antibody to an Fc receptor present on the surface of a cell as well as to a method for determining the level of glycosylation of an antibody. The invention also relates to a reagent kit for carrying out these methods.

Abstract: The instant invention provides for methods for detecting the internalization of a transmembrane protein of interest expressed at the surface of a cell. More specifically, the methods involve (a) labelling the protein of interest with a fluorescent metal complex, the lifetime of which is greater than 0.1 ms, (b) adding to the reaction medium a composition capable of causing the internalization of the protein of interest, (c) adding to the reaction medium (1) a modulating agent which is a fluorescent FRET acceptor compound compatible with the fluorescent metal complex, the final concentration of which in the reaction medium is greater than 10?7M; or (2) a reducing agent, the redox potential of which is less than +0.1 V and preferably between 0.25 and 0.

Abstract: The invention relates to a method for detecting the binding of an antibody to an Fc receptor present on the surface of a cell as well as to a method for determining the level of glycosylation of an antibody. The invention also relates to a reagent kit for carrying out these methods.

Abstract: The invention relates to a quantitative non-microscopic method of detecting intracellular interactions between biomolecules in living cells, in response to a biological or pharmacological stimulation, by a time-resolved proximate energy transfer effect between two members of a fluorescence donor/acceptor pair.

Abstract: A method for detecting the internalization of a transmembrane protein of interest expressed at the surface of a cell, comprising the following steps: a) labelling the protein of interest with a fluorescent metal complex, the lifetime of which is greater than 0.1 ms; b) adding to the reaction medium a composition capable of causing the internalization of the protein of interest; c) adding to the reaction medium a modulating agent selected from: a. a fluorescent or nonfluorescent FRET acceptor compound compatible with said fluorescent metal complex, the final concentration of which in the reaction medium is greater than 10?7M; b. a reducing agent, the redox potential of which is less than +0.1 V and preferably between 0.25 and 0.75 V; c. an agent which binds specifically, by noncovalent bonding, with the fluorescent metal complex; d.

Abstract: The present invention relates to a quantitative non-microscopic method of detecting intracellular interactions between biomolecules, on living cells, in response to a biological or pharmacological stimulation, by a time-resolved proximate energy transfer effect between two members of a fluorescence donor/acceptor pair.

Abstract: A purified protein comprising a mechanosensitive potassium channel activated by at least one polyunsaturated fatty acid and riluzole and the use of said channels in drug screening.

Abstract: A purified protein including a mechanosensitive potassium channel activated by at least one polyunsaturated fatty acid and riluzole and the use of channels in drug screening.

Abstract: Human and mouse TREK-1 potassium transport proteins are disclosed as well a method for using potassium transport proteins for identifying substances having anesthetic properties, such as producing a safe, reversible state of unconsciousness with concurrent amnesia and analgesia in a mammal upon inhalation, in a method comprising (a) contacting the test substance with a mammalian potassium transport protein, wherein said potassium transport protein exhibits outward-going potassium rectification; and (b) determining the potassium transport activity of the potassium transport protein, wherein an activation of potassium transport is indicative of the test substance having anesthetic properties.

Abstract: The present invention relates to a method for the detection of ligands (agonists or antagonists) specific for a G protein-coupled receptor (GPCR), which comprises the steps consisting in: 1) bringing a receptor labelled with a member of a donor/acceptor pair into contact with a G? or G?? subunit of a G protein labelled with the other member of the donor/acceptor pair; 2) measuring the transfer by proximity effect between the donor and the acceptor.

Abstract: This invention relates to the cloning of a member of a new potassium channel named TWIK-1. More specifically, it relates to an isolated and purified nucleic acid molecule coding for a protein constituting a potassium channel exhibiting the proper-ties and structure of the TWIK-1 type channel, as well as the protein coded by this nucleic acid molecule. The invention also relates to the use of this nucleic acid molecule to transform cells, and the use of these cells expressing the potassium channels exhibiting the properties and structure of the TWIK-1 type channel for the screening of drugs.

Abstract: A purified protein comprising a mechanosensitive potassium channel activated by at least one polyunsaturated fatty acid and riluzole and the use of said channels in drug screening.

Abstract: A purified protein comprising a mechanosensitive potassium channel activated by at least one polyunsaturated fatty acid and riluzole and the use of such channels in drug screening.

Abstract: The present invention relates to the identification of a capacitative calcium channel homologue for the immune system activation, and its use to report and to modulate modulate the activity of immune cells in vitro, ex vivo or in vivo. This invention more specifically discloses that a Mlsn1 gene product, represents a capacitative calcium channel in immune cells such as macrophages, monocytes, T-cells, B-cells and mast-cells. This invention is a proven identification of a gene expressing a capacitative calcium channel in immune cells, and can be used in various compositions and methods for monitoring or modulating an immune response in a subject. The present invention can be used to develop biomarkers for immune system activation or inflammatory responses or to screen for specific immune system activity altering drugs.

Abstract: This invention relates to a new member of a recently recognized TWIK potassium + channel family, herein identified as TASK. For TWIK-related acid-sensitive K + channel. This is the first cloned mammalian channel that produces K+ currents that possesses all the characteristics of background conductances. The inventions also relates to various constructs including the TASK or related human potassium channel family, and their uses.

Abstract: This invention relates to a new member of a recently recognized TWIK potassium+ channel family, herein identified as TASK. For TWIK-related acid-sensitive K+ channel. This is the first cloned mammalian channel that produces K+ currents that possesses all the characteristics of background conductances The inventions also relates to various constructs including the TASK or related human potassium channel family, and their uses.

Abstract: This invention relates to a new member of a recently recognized TWIK potassium+channel family, herein identified as TASK, for TWIK-related acid-sensitive K+ channel. This is the first cloned mammalian channel that produces K+ currents that possesses all the characteristics of background conductances. The invention also relates to various constructs including the TASK or related human potassium channel family, and their uses.

Abstract: The present invention relates to the cloning of a member of a new potassium channel named TWIK-1. More specifically, it relates to an isolated and purified nucleic acid molecule coding for a protein constituting a potassium channel exhibiting the properties and structure of the TWIK-1 type channel, as well as the protein coded by this nucleic acid molecule.The invention also relates to the use of this nucleic acid molecule to transform cells, and the use of these cells expressing the potassium channels exhibiting the properties and structure of the TWIK-1 type channel for the screening of drugs.